Abstract: Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP2. Methods of using these compounds for modulation of eIF4E-BP2 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP2 are provided.
Type:
Grant
Filed:
November 19, 2008
Date of Patent:
November 29, 2011
Assignee:
Isis Pharmaceuticals, Inc.
Inventors:
Sanjay Bhanot, Kenneth W. Dobie, Ravi Jain