Abstract: The invention provides novel compounds which are capable to stimulate the proliferation or/and the outgrowth from cells presenting the neural cell adhesion molecule (NCAM). Additionally, the invention relates to pharmaceutical compositions, medicaments and methods for treatment of normal, degenerated and damaged NCAM presenting cells.
Type:
Grant
Filed:
September 23, 1999
Date of Patent:
May 3, 2005
Inventors:
Lars Christian Ronn, Arne Holm, Marianne Olsen, Soren Ostergaard, Peter H. Jensen, Flemming M. Poulsen, Vladislav Soroka, Igor Ralets, Vladimir Berezin, Elisabeth Bock
Abstract: An antigen which, as its major immunizing component, comprises a determinant of an adhesin polypeptide or an immunogenically active subsequence thereof or a precursor therefor which is convertible to an immunogenically active form, antibodies against which determinant react with the adhesin polypeptide produced by pathogenic adhesin-forming bacteria which adhere to mammalian tissue, antibodies against such antigen, and DNA expressing, as a principal gene product thereof, such antigen.
Type:
Grant
Filed:
May 23, 1995
Date of Patent:
September 8, 1998
Assignee:
Symbicom Aktiebolag
Inventors:
Frederik Carl Lindberg, Bjorn Olof Lund, Britt Monika B.ang.ga, Mari Elisabet Norgren, Mikael Goransson, Bernt Eric Uhlin, Jan Staffan Normark, David Lee Lark