Patents Represented by Attorney, Agent or Law Firm Ivor M. Hughes
  • Patent number: 8028361
    Abstract: An infant support device for supporting an infant in a prone position, comprising a base with a front, a back, a top, a bottom and two side members, said base having a support surface extending between the side members on the top of the base; the support surface being defined by two portions: (I) a body support surface disposed proximate the front of the support device and terminating adjacent the front of the device, and (II) a leg support surface extending rearwardly from terminus of the body support surface toward the back of the device; and having a grip for retaining the posterior side of the legs of the infant and extending upwardly from the support surface between the side members; wherein an infant is supported in a prone position on the support surface between the side members, and the legs are supported on the leg support surface and are retained by said grip to minimize infant rollover toward a supine position.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: October 4, 2011
    Inventors: Kevin Ramer, Gabriela Ramer
  • Patent number: 7410985
    Abstract: The present invention provides an cycloalkyl derivative of 3-hydroxy-4-pyridinone which is useful for the chelation of metal ions such as iron. Its preparation and use is described. In particular, the invention concerns the removal of iron in chemical and biological systems including chelating agents having the formula (I); wherein R1 is X with the proviso that R2 is Y; or R1 is T with the proviso that R2 is W; or R1 is X with the proviso that R2 R5 N when taken together form a heterocyclic ring selected from piperidinyl, morpholinyl, pyrrolidinyl or piperazinyl, wherein the group piperidinyl, morpholinyl, pyrrolidinyl or piperazinyl is either unsubstituted or substituted with one to three C1 to C6 alkyl groups.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: August 12, 2008
    Assignee: Apotex Inc.
    Inventors: Tim Fat Tam, Michael Spino, Wanren Li, Yingsheng Wang, Yanqing Zhao, Birenkumar Hasmukhbhai Shah
  • Patent number: 7375233
    Abstract: The present invention provides a novel and improved process for the preparation of Zonisamide and the intermediates thereof.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: May 20, 2008
    Assignee: Apotex Pharmachem Inc.
    Inventors: Gamini Weeratunga, Eckardt C. G. Wolf, Nageib Mohamed, Allan W. Rey, Bhaskar Reddy Guntoori
  • Patent number: 7365201
    Abstract: A process for the preparation of the boron difluoride chelate of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolone carboxylic acid via: (a) the reaction of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolone carboxylic acid ethyl ester with, (b) fluoroboric acid in the presence of poly(methylhydrosiloxane) or hexamethyldisiloxane.
    Type: Grant
    Filed: March 2, 2006
    Date of Patent: April 29, 2008
    Assignee: Apotex Pharmachem Inc.
    Inventors: Zhi-Xian Wang, Murali Kondamreddy, Joseph DiMartino, Bhaskar Reddy Guntoori
  • Patent number: 7271253
    Abstract: A process for the preparation of Balsalazide and its pharmaceutically acceptable salts wherein the reaction comprises: a. the intermediate N-(4-aminobenzoyl)-?-alanine is converted to N-(4-ammoniumbenzoyl)-?-alanine sulfonate salt using a sulfonic acid in water, b. the N-(4-ammoniumbenzoyl)-?-alanine sulfonate salt is treated with aqueous sodium nitrite solution at low temperature to generate N-(4-diazoniumbenzoyl)-?-alanine sulfonate salt, c. the aqueous solution obtained is quenched with aqueous disodium salicylate to furnish Balsalazide disodium solution, d. the solution is acidified to allow isolation of Balsalazide, and e. optionally converting the Balsalazide to a pharmaceutically acceptable salt (such as disodium salt).
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: September 18, 2007
    Assignee: Apotex Pharmachem Inc.
    Inventors: Eckardt C. G. Wolf, Nageib Mohamed, Bhaskar Reddy Guntoori
  • Patent number: 7210513
    Abstract: A sliding screen frame for a closure assembly having an opening and an existing track for mounting a screen, the screen frame has framing sections with both inner and outer side edges, and a housing from which a screen is payed out and accumulated. The framing sections are adapted on the outer side edge to interfit with the existing track of the closure assembly to enable the sliding screen frame to slide across the opening of the closure assembly and the frame sections also being adapted on the inner side edge thereof to support and guide the free end of the screen between a fully payed out and a fully accumulated position. The screen frame has a mitreless corner connector for connecting adjacent framing sections without the need for mitre cuts thereof to establish continuity between the corner connector and the adjacent framing sections.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: May 1, 2007
    Assignee: 420820 Ontario Limited
    Inventors: Shaul Goldenberg, Sean Davies, Sinnathamby Kupenthirarajan
  • Patent number: 7138523
    Abstract: A process for the industrial scale manufacture of 4-(4-fluorophenyl)-N-alkylnipecotinate esters by the addition of 4-fluorophenylmagnesium halide in tetrahydrofuran to 3,4-unsaturated-3-piperidine esters.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: November 21, 2006
    Assignee: Apotex Pharmachem Inc.
    Inventors: Allan W. Rey, K. S. Keshava Murthy, Bruno K. Radatus, Yajun Zhao, Tania E. Nish
  • Patent number: 7049399
    Abstract: A process for the preparation of a polypeptide designated in the present invention as 1, composed of the following amino acid units in the structure, namely: L-alanine, L-glutamic acid, L-lysine and L-tyrosine randomly arranged in the polypeptide 1, or pharmaceutically acceptable salts thereof, comprising the steps of: (a) polymerization of a mixture of the N-carboxyanhydrides of L-alanine, L-tyrosine, a protected L-glutamate and a protected L-lysine to obtain protected copolymer 6 or salt thereof; (b) deprotection of the protected copolymer 6 (or salt thereof) to produce polypeptide 1 or a pharmaceutically acceptable salt thereof in one single step; (c) separation and purification of the polypeptide 1 (or a pharmaceutically acceptable salt) to obtain a purified polypeptide 1
    Type: Grant
    Filed: December 24, 2002
    Date of Patent: May 23, 2006
    Assignee: Apotex Pharmachem Inc.
    Inventors: Elena Bejan, Gamini Weeratunga, Stephen E. Horne
  • Patent number: 6812222
    Abstract: The present invention relates to a peritoneal dialysis solution comprising at least one amino sugar in an effective amount sufficient to create an osmotic pressure to effect the removal of water by diffusion from the patient's blood across the peritoneal membrane into the solution. In one embodiment the at least one amino sugar is selected from the group consisting of acetylated amino sugars, preferably N-acetylglucosamine, deacetylated amino sugars and combinations thereof.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: November 2, 2004
    Inventors: George Wu, Paul Y. Tam, Ian W. French
  • Patent number: 6767556
    Abstract: Stable solid compositions comprising moxeipril magnesium can be made using moexipril or an acid addition salt thereof, by reacting the moxeipril or acid addition salt with an alkaline magnesium compound in the presence of a solvent, so as to convert most or all of the moexipril or acid addition salt to moexipril magnesium.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: July 27, 2004
    Inventor: Bernard Charles Sherman
  • Patent number: 6740340
    Abstract: A pharmaceutical tablet which incorporates two smaller tablets, one of which comprises an NSAID and the other of which comprises misoprostol.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: May 25, 2004
    Inventor: Bernard Charles Sherman
  • Patent number: 6726588
    Abstract: The differential engine comprises a motor, a torque conversion stage, and a loading mechanism. The torque conversion stage includes first and second differential stages which are coupled together with a pair of shafts, with the shafts rotating in opposite directions. The first differential stage comprises an input shaft which is coupled to the output shaft of the motor, and first and second output shafts which are coupled to the respective shafts. The second differential stage comprises an output coupled to the output drive shaft, and first and second input shafts which are coupled to the respective shafts. The second differential stage includes a gear mechanism which applies a rotational torque to the output drive shaft when a difference occurs between the rotational speeds for the shafts. The rotational speeds of the shafts are varied by loading one or both of the shafts.
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: April 27, 2004
    Assignee: CVET Patent Technologies, Inc.
    Inventor: Ervin Weisz
  • Patent number: 6713495
    Abstract: Improved process to produce magnesium omeprazole substantially amorphous with pharmaceutically acceptable low level of methanol and solid pharmaceutical compositions.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: March 30, 2004
    Inventor: Bernard Charles Sherman
  • Patent number: 6712404
    Abstract: A handle for a movable closure, such as a screen having at least one edge frame preferably for retaining a screen cloth, said closure being movable into a slot-like recess disposed in a structure against which the closure engages. The handle comprising a first inside flexible member and a second outside flexible member.
    Type: Grant
    Filed: May 29, 2001
    Date of Patent: March 30, 2004
    Assignee: Preferred Engineering Products Ltd.
    Inventors: Sean Davies, Sinnathamby Kupenthirarajan
  • Patent number: 6701994
    Abstract: A sliding screen frame for a closure assembly, the frame comprising framing sections assembled to form the screen frame, one of the frame sections being adapted to contain a roll out screen, the roll out screen being slidable between a fully extended position, whereat the screen is substantially payed out from the roll, and a fully retracted position; wherein the screen frame is free to slide in the closure assembly whether the roll screen is at the fully extended or the fully retracted position.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: March 9, 2004
    Assignee: 420820 Ontario Limited
    Inventors: Shaul Goldenberg, Sean Davies, Sinnathamby Kupenthirarajan
  • Patent number: 6679002
    Abstract: A reinforcing block for a closure tilt latch, comprising a body fastened in a closure track fastened to a frame, said body having a top and bottom and having a locking detent extending therein said locking detent providing a vertical face extending toward said top of said body from intermediate said top and bottom, the tilt latch being compatible with the vertical face of said locking detent, wherein when said latch engages said detent said block provides a reinforcement path to the closure frame to strengthen the loading capability of said closure and to reduce the risk of the latch from disengaging said track under loading which track would be subject to distortion had the block not been utilized.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: January 20, 2004
    Assignee: 420820 Ontario Limited
    Inventors: John Robert Davies, Sean Davies, Sinnathamby Kupenthirarajan
  • Patent number: D525440
    Type: Grant
    Filed: November 16, 2004
    Date of Patent: July 25, 2006
    Inventors: Richard Machacek, Ana Jurpik
  • Patent number: D484991
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: January 6, 2004
    Assignee: 420820 Ontario Limited
    Inventors: Sean Davies, Shaul Goldenberg, Sinnathamby Kupenthirarajan
  • Patent number: D494401
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: August 17, 2004
    Assignee: 420820 Ontario Limited
    Inventors: Sean James Davies, Shaul Goldenberg, Sinnathamby Kupenthirarajan
  • Patent number: D623426
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: September 14, 2010
    Inventors: Kevin Ramer, Gabriela Ramer