Patents Represented by Attorney J. J. McDonnell

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  • Hapten-inhibitor immunoassay
    Patent number: 4430263
    Abstract: A specific binding assay method employing, as a labeling substance, a reversible trypsin inhibitor for the detection of a hapten. Competition between the hapten to be determined and hapten trysin inhibitor conjugate for antibody to the hapten, in the presence of enzyme, followed by addition of enzyme substrate provides an effective method for hapten analysis. The preferred trypsin inhibitor is a protein having a molecular weight range of 2,000-75,000. The preferred ratio of the hapten to the inhibitor in the conjugate is between 1:1 and 3:1.
    Type: Grant
    Filed: January 21, 1980
    Date of Patent: February 7, 1984
    Assignee: Abbott Laboratories
    Inventors: Steven C. March, John W. Safford, Jr., Susan E. Magic
  • Phenoxyldialkyl acetic acids and esters
    Patent number: 4163859
    Abstract: The present invention encompasses compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are independently an alkyl radical containing from 1 to 2 carbon atoms and R.sup.3 is hydrogen or an alkyl radical containing from 1 to 7 carbon atoms, sodium, potassium, or ammonium cation. The compounds of the present invention are prepared by the condensation of alkyl(4-formylphenoxy)-2,2-dialkylacetate with acetophenone in basic medium. These compounds are potent hypolipemic agents as well as antifungal and antibacterial agents.
    Type: Grant
    Filed: July 18, 1977
    Date of Patent: August 7, 1979
    Assignee: G. D. Searle & Co.
    Inventor: William K. Sprenger, deceased