Patents Represented by Attorney J. Scott Young

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  • Benzo[f]isoindole derivatives with affinity to the EP4 receptor
    Patent number: 7166631
    Abstract: The present invention relates to a compound of formula (I): corresponding pharmaceutical compositions, preparation processes, and/or methods of using the aforementioned compounds and/or compositions.
    Type: Grant
    Filed: February 7, 2002
    Date of Patent: January 23, 2007
    Assignee: Glaxo Group Limited
    Inventors: Miles Stuart Congreve, Gerard Martin Paul Giblin, Ann Louise Walker
  • Substituted pyrimidines as selective cyclooxygenase-2 inhibitors
    Patent number: 7084148
    Abstract: A compound of formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1 is H or C1-6alkyl; R2 is wherein defines the point of attachment of the ring; and R3 is C1-6alkyl or NH2. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of pain, fever, inflammation of a variety of conditions and diseases.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: August 1, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Malcolm Clive Carter, Alan Naylor, Martin Pass, Jeremy John Payne, Neil Anthony Pegg
  • Pyrimidine derivatives as selective inhibitors of cox-2
    Patent number: 7074802
    Abstract: The invention thus provides the compounds of formula (I) and pharmaceutically acceptable salts thereof, in which: R1 and R2 are independently selected from the group consisting of H, C1-6alkyl, C2-6alkenyl, C3-6alkynyl, C3-10cycloalkylC0-6alkyl and C4-12bridged cycloalkyl; R3 is selected from the group consisting of C1-6alkyl, NH2 and R5CONH; R4 is selected from the group consisting of CH2F, CHF2, CF3CH2, CF3CHF and CF3CF2; and R5 is selected from the group consisting of H, C1-6alkyl, C1-6alkoxy, C1-6alkylOC1-6alkyl, phenyl, HO2CC1-6alkyl, C1-6alkylOCOC1-6alkyl, C1-6alkylOCO, H2NC1-6alkyl, C1-6alkylOCONHC1-6alkyl and C1-6alkylCONHC1-6alkyl. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: July 11, 2006
    Assignee: Glaxo Group Limited
    Inventors: Jennifer Doughty, legal representative, Charles David Hartley, Alan Naylor, Jeremy John Payne, Neil Anthony Pegg, Richard Howard Doughty, deceased
  • Pyrimidine derivatives as selective inhibitors of COX-2
    Patent number: 7056928
    Abstract: The invention provides the compounds of formula (I) and pharmaceutically acceptable salts thereof, in which: R1 and R2 are independently selected from H, or C1-6alkyl; R3 is selected from the group consisting of C1-6alkyl, NH2 and R6CONH; R4 is H or C1-6alkyl; R5 is selected from the group consisting of CH2F, CHF2, CF3CH2, CF3CHF and CF3CF2; A is a 5- or 6-membered aryl, or a 5- or 6-membered aryl substituted by one or more R7; R6 is selected from the group consisting of H, C1-6alkyl, C1-6alkoxy, C1-6alkylOC1-6alkyl, phenyl, HO2CC1-6alkyl, C1-6alkylOCOC1-6alkyl, C1-6alkylOCO, H2NC1-6alkyl, C1-6alkylOCONHC1-6alkyl and C1-6alkylCONHC1-6alkyl; R7 is selected from the group consisting of halogen, C1-6alkyl, C1-6alkyl substituted by one or more F, C1-6alkoxy, C1-6alkoxy substitued by one or more F, SO2NH2 or SO2C1-6alkyl; and n is 1 to 4.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: June 6, 2006
    Assignee: Glaxo Group Limited
    Inventors: Malcolm C Carter, Alan Naylor, Jeremy J Payne, Neil A Pegg