Patents Represented by Attorney J. W. Williams, Jr.
  • Patent number: 4879371
    Abstract: A resin and method for using the resin for solid phase peptide synthesis. The resin has a sulfoxide linkage, which is stalbe to strong acid conditions. The sulfoxide linkage can be reduced to a sulfide linkage, which allows cleavage of the peptide from the resin under mild acid conditions.
    Type: Grant
    Filed: June 20, 1988
    Date of Patent: November 7, 1989
    Assignee: Monsanto Company
    Inventors: Daniel P. Getman, Robert M. Heintz
  • Patent number: 4843006
    Abstract: This invention relates to the expression and accumulation in bacterial cells of heterologous polypeptides under the control of the recA promoter/operator region. One such polypeptide comprises a recA/somatostatin fusion polypeptide. This fusion polypeptide has been expressed and accumulated by E. coli with much greater effectiveness than other somatostatin-containing fusion polypeptides. In addition, use of the recA promoter/opeerator region provides greater induction flexibility than other inducible promoter systems.
    Type: Grant
    Filed: April 21, 1986
    Date of Patent: June 27, 1989
    Assignee: Monsanto Company
    Inventor: Michael L. Bittner
  • Patent number: 4829052
    Abstract: Synthetic polypeptides are disclosed which exhibit potent serine protease inhibition. Methods and compositions useful for treating conditions caused by unwanted serine protease activity are also disclosed.
    Type: Grant
    Filed: May 8, 1987
    Date of Patent: May 9, 1989
    Assignee: Monsanto Company
    Inventors: George I. Glover, Charles A. McWherter, Charles S. Schasteen
  • Patent number: 4293393
    Abstract: The invention is a process for using certain electrogenerated bases in reactions such as acetoacetic ester condensations wherein an azobenzene probase is electro-reduced to produce an electrogenerated base, acetic ester is deprotonated by electrogenerated base to produce an anion, and the anion is condensed with acetic ester to produce acetoacetic ester condensation product; the probase being more easily electro-reducible than the acetic ester and producing an electrogenerated base strong enough to deprotonate the acetic ester which is sufficiently acidic to permit such deprotonation. The probase can be regenerated, either directly or indirectly, by anodic oxidation to probase making the reaction catalytic.
    Type: Grant
    Filed: January 18, 1980
    Date of Patent: October 6, 1981
    Assignee: Monsanto Company
    Inventors: Richard C. Hallcher, Richard D. Goodin, Manuel M. Baizer
  • Patent number: 4229188
    Abstract: There is provided an improved, environmentally acceptable adsorption process for the recovery of hydrogen and normally liquid hydrocarbon from a feed gas mixture by utilizing a membrane permeator unit selectively permeable to hydrogen to recover a permeated hydrogen gas from the purge gas obtained from the regeneration of a selective adsorption unit, recycling the permeated hydrogen gas to a guard adsorber of the selective adsorption unit as purge gas and blending said gas with the feed gas mixture for recovery of normally liquid hydrocarbon and of the added proportion of hydrogen as purified hydrogen product.
    Type: Grant
    Filed: June 18, 1979
    Date of Patent: October 21, 1980
    Assignee: Monsanto Company
    Inventor: George M. Intille
  • Patent number: 4189610
    Abstract: Dehydrohalogenation-rearrangement of 1,1-bis(4-oxy-substituted aryl)-2-haloethanes to yield 4,4'-dioxysubstituted stilbenes is effected by heating an acidic reaction medium comprising the 1,1-bis(4-oxy-substituted aryl)-2-haloethane dissolved in a solution of an aliphatic carboxylic acid and a carboxylic acid salt. The process is particularly directed to the preparation of 4,4'-dihydroxystilbene from 1,1-bis(4-hydroxyphenyl)-2-chloroethane.
    Type: Grant
    Filed: October 31, 1977
    Date of Patent: February 19, 1980
    Assignee: Monsanto Company
    Inventor: James P. Coleman