Abstract: Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.

Abstract: A compound of the formula is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions for inhibiting HIV protease activity and treating HIV infection are also disclosed.

Abstract: Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.

Abstract: The present invention is directed to a method for inducing UGT1A1 isoform expression for treatment of a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate comprising the step of administering to a subject an effective amount of ritonavir. In particular, the present invention is directed to a method of treating unconjugated hyperbilirubinemia by UGT1A1 induction comprising the step of administering to a subject an effective amount of ritonavir.

Abstract: An exemplary collapsible game feeder and method are provided. In one embodiment, the collapsible game feeder includes a collapsible container and a dispensing device. The collapsible container may receive and store feed and release feed to the dispensing device for dispensing external the collapsible game feeder. In another aspect of the invention, a method for transporting and using a collapsible game feeder. The method includes providing a collapsible game feeder, transporting the collapsible game feeder to a desired location in the collapsed state, filling the collapsible game feeder with feed, and using the collapsible game feeder by having it dispense feed. The present invention also encompasses other embodiments and methods.

Abstract: The present invention is directed to a method for inducing UGT1A1 isoform expression for treatment of a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate comprising the step of administering to a subject an effective amount of ritonavir. In particular, the present invention is directed to a method of treating unconjugated hyperbilirubinemia by UGT1A1 induction comprising the step of administering to a subject an effective amount of ritonavir.

Abstract: An external wheeled heeling apparatus for walking and running and transitioning to rolling on a surface is provided. The apparatus includes a sole having a forefoot, an arch and a heel portion provided with a first side of the heel portion and a second side of the heel portion. The forefoot operable to engage the surface for walking and running. The apparatus further includes a first wheel operably coupled to rotate adjacent the first side of the heel portion and a second wheel operably coupled to rotate adjacent the second side of the heel portion.

Abstract: A grind rail apparatus coupleable to an underside of a footwear for grinding is provided. The grind rail apparatus includes a body having an upper side and a lower side, the upper side of the body coupled to the underside of the footwear. The grind rail apparatus also includes a plurality of rails extending from the lower side of the body.

Abstract: A rock laminate has been provided that includes a layer of rock and a flexible layer. The layer of rock has a plurality of pores that can receive fluid. The flexible layer is positioned above the layer of rock and has a portion which extends into the pores of the layer of rock. Additionally a method for making a rock laminate is provided. The method includes providing a rock having an exposed surface and applying a polymer that bonds with the exposed surface. The polymer is lifted along with corresponding bonded portion of the exposed surface is lifted from the rock.

Abstract: A heeling apparatus includes a shoe with a unique feature in the heel that allows one to walk, run, or roll seamlessly. The appearance is that of normal footwear because of the covert wheel assembly. The stealth wheel in the heel gives one the ability to roll or slide in areas you could only walk. Heeling is a new activity that employs a unique method of rolling and requires a newly learned skill set of balance, positioning, and coordination.

Abstract: Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X1, X2, X3, X4, X5, R5, R6, R7, R8a, R8b, R9, Z1, Z2 and L are as defined in the description.

Abstract: Compounds of formula (I) are novel P2X3 and P2X2/P2X3 antagonists which are useful in treating pain, urinary incontinence and bladder overactivity.

Abstract: Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.

Abstract: A heeling apparatus includes a shoe with a unique feature in the heel that allows one to walk, run, or roll seamlessly. The appearance is that of normal footwear because of the covert wheel assembly. The stealth wheel in the heel gives one the ability to roll or slide in areas you could only walk. Heeling is a new activity that employs a unique method of rolling and requires a newly learned skill set of balance, positioning, and coordination.

Abstract: Cyanide-free reagents for the determination of hemoglobin and leukocytes present in a blood sample comprise an aqueous solutions of at least one quaternary ammonium salt, preferably selected from the group of alkyltrimethylammonium salts, alkyldimethylbenzylammonium salts or alkylpyridium salts consisting of tetradecyltrimethyl ammonium bromide (TTAB), dodecyltrimethyl ammonium chloride, cetyltrimethyl ammonium bromide, hexadecyltrimethyl ammonium bromide and benzalkonium chlorides, and hydroxylamine salts, especially hydrochloride, sulfate and phosphates and other acid salts. The method involves mixing the reagent with a diluent-diluted blood sample, presenting it to an absorbance spectrophotometer and measuring the resulting optical density as an indicator of hemoglobin concentration. This cyanide-free reagent could be used solely for hemoglobin determinations, or, it can also be used in leukocyte counting and sizing using hematology instrumentation.

Abstract: A heeling apparatus includes a shoe with a unique feature in the heel that allows one to walk, run, or roll seamlessly. The appearance is that of normal footwear because of the covert wheel assembly. The stealth wheel in the heel gives one the ability to roll or slide in areas you could only walk. Heeling is a new activity that employs a unique method of rolling and requires a newly learned skill set of balance, positioning, and coordination.

Abstract: A multi-wheel heeling apparatus is provided. The multi-wheel heeling apparatus has a sole with a first opening formed in a heel portion of the sole and a second opening in the sole formed adjacent the first opening. The multi-wheel heeling apparatus includes a first and a second wheel assemblies. The first wheel assembly includes a first wheel mounted on a first axle, and a first mounting structure operable to support the first axle so that a portion of the first wheel resides in the first opening. The second wheel assembly includes a second wheel mounted on a second axle, and a second mounting structure operable to support the second axle so that a portion of the second wheel resides in the second opening.

Abstract: A process for extracting and purifying naturally occurring zeolite from ores in the presence of other mineral phases by using mechanical dispersion and differential suspension to remove a majority of the clay content of the ore. The process continues by removal of contaminants with a higher mass to surface area ratio than that of the desired zeolite product by employing the properties of demineralized water in combination with a countercurrent flow separation column. No chemical flocculating or flotation agents are employed in the process. The process separates the particulate compound by using the separation effect of an electrical double layer which forms when the mixture is hydrated in a low electrolyte medium.

Abstract: Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Abstract: The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.