Abstract: Lipid Membrane Structures comprising Digalactosyl Diglyceride target the liver of humans and lower animals and are used to carry drugs to that organ, preferentially. Digalactosyl Diglyceride LMS containing insulin provide an effective means for treating diabetes mellitus. Digalactosyl Diglyceride LMS containing interferon are used to treat viral hepatitis.

Abstract: Polyol esters of alpha-hydroxy carboxylic acids are disclosed which are excellent oil-in-water emulsifiers for food products, drug delivery vehicles, cosmetic ointments and the like. The compounds are also useful as detergent surfactants and can be combined with cosurfactants, builders and detergent adjunct materials.

Abstract: Solid detergent compositions containing alpha-amine oxide surfactants and alkaline materials, which exhibit a pH of greater than 9.0 at a concentration of 1% by weight in water, are disclosed. The alpha-amine oxides have improved stability against metal-catalyzed decomposition in the present compositions. The compositions preferably also contain other surfactants and detergent adjunct materials.

Abstract: A novel process for the oxidation of olefins to the corresponding alpha-epoxy alcohols which can be incorporated in the total synthesis of members of a novel class of prostaglandin analogues.Olefins are reacted with singlet oxygen in the presence of a group IVB, VB or VIB transition metal catalyst, excluding chromium. The reaction is fast and highly selective to the alpha-epoxy alcohol. When cyclopentene is oxidized in the process of the invention, high yields of cis 2,3-epoxy-cyclopentan-1-ol are obtained. The latter compound is used as a starting material in the synthesis of prostaglandin analogues. The prostanoids of the invention are characterized by an oxa group replacing the methylene group at the 7-position, and the absence of a hydroxyl or other substituent at the 11-position.Members of this class of prostanoids show important cytoprotective properties in animal tests.

Abstract: Topical antimicrobial anti-inflammatory compositions, having a pH no greater than about 5, containing C.sub.5 -C.sub.12 fatty acids together with a corticosteroid component, are disclosed. The method of topically treating inflammatory skin conditions using these compositions is also disclosed.

Abstract: Compositions comprising pharmaceutically-acceptable gold salts and organophosphonates, especially the geminal diphosphonates, useful in the treatment of arthritic conditions, are disclosed. The method of treating arthritic conditions using these compositions is also disclosed.

Abstract: Certain oxaalkanoate zwitterionic surfactant-type compounds and their esters are not only excellent detergents, but also provide superior oral therapy for ulceration of the gastric mucosa. The oxaalkanoate zwitterionic compounds are especially preferred in the management of both gastric and duodenal ulcers.

Abstract: Improved reinforced devices, which can be retained in the vagina during intercourse, deliver spermicidal surfactants and provide contraceptive benefits. Lobed devices provide channels through which menses and other biological fluids can pass. Multi-compartment devices provide added protection against leakage, rupture or perforation during manufacture, handling and use.

Abstract: Zwitterionic surfactant compounds provide effective therapy for ulceration of the gastric mucosa. The tendency of aspirin and other salicylate-based drugs to cause ulceration of the gastric mucosa is also reduced by administration of such drugs in conjunction with certain zwitterionic surfactants. The ammoniohexanoate zwitterionics are especially preferred in the management of both gastric and duodenal ulcers.

Abstract: Peroxygen fabric bleaching compounds capable of yielding hydrogen peroxide in an aqueous solution are activated by long chain acyl compounds of the formula ##STR1## wherein Z is a leaving group which can be certain enols, carbon acids or N-alkyl quaternary imidazoles. The activated bleaching compositions herein are stable and especially suitable for use at relatively low temperatures. Bleaching processes and detergent compositions containing the bleaching compositions are also described.

Abstract: A method of preparing hydroxyl substituted ammonio carboxylates comprising a single step of reacting an epoxy ester with a tertiary amine in aqueous alcohol, yielding directly said hydroxyl substituted ammonio carboxylates. The hydroxyl substituted ammonio carboxylates are useful as detersive surfactants and as oral anti-ulcer agents.

Abstract: 1,4-Bis(dicyanomethylene)cyclohexane is the chemical of choice for the synthesis of TCNQ. The present invention provides a simple convenient, three-step synthesis of 1,4-bis(dicyanomethylene)cyclohexane from hydroquinone which uses water as the reaction solvent.

Abstract: A density separation process for recovering vegetable seed protein granules from the remaining portion of the vegetable seeds, using an aqueous single-phase solution of an organic acid salt, said aqueous solution having a density of from about 1.2 to about 1.45 g/ml and a water activity of from about 0.40 to about 0.85.

Abstract: A nonionic, highly ethoxylated anti-static agent, preferably in combination with a fabric softening composition comprising particular mixtures of mono-, di- and tri-glycerides and fatty alcohols, is applied to fabrics in an automatic dryer.

Abstract: A device which is used in the vagina to deliver spermicidal surfactants. This device can be inserted by the user, and does not require insertion by a physician as, for example, in the case of intrauterine contraceptive devices. By virtue of its unique construction and shape, the device herein is foldable for easy insertion. Once in position at the cervical os, the device opens to "cap" the os and remain in position, even during intercourse, so that access of the spermicidal surfactant source to the cervical os is not interrupted. The device is designed to remain comfortably in the vagina during the time between menstrual periods to provide desirable, prolonged release of a spermicidal surfactant, and its construction and shape facilitate retention therein while minimizing awareness and discomfort. An effective between-period contraceptive device is thereby provided.

Abstract: Compositions containing salicylic acid derivatives are useful for topical application to the skin. The compositions are especially effective for providing an anti-inflammatory effect.

Abstract: Cellulose-based soil release ethers are used in detergent compositions containing C.sub.10 -C.sub.12 alkyl benzene sulfonate surfactants, and substantially free from interfering longer-chain length alkyl benzene sulfonates, to provide optimal soil release performance.

Abstract: Cyclopropanecarboxylic acid esters of 3-coumaranol and substituted 3-coumaranols possessing useful insecticidal properties.

Abstract: Hair bleaching compositions containing arginine or various proteins or polypeptides having a high arginine content, a peroxide compound and a bleaching accelerator as essential components.

Abstract: Detergent-compatible fabric softening and anti-static compositions containing particular smectite clay materials, cationic anti-static agents and acidic compatibilizing agents are described. The compositions permit the simultaneous attainment of fabric softening, static-reduction and cleaning effects of fabrics washed therein.