Abstract: Gene therapy can treat obesity in mammals. An adenoviral vector encoding a leptin gene is delivered intravenously to a mammal with a deficiency in functional leptin to decrease weight, decrease serum insulin levels or decrease serum glucose levels.
Type:
Grant
Filed:
June 19, 1997
Date of Patent:
December 14, 1999
Assignee:
Merck & Co., Inc.
Inventors:
Manal A. Morsy, Ming Cheng Gu, Jing Zhoa, C. Thomas Caskey