Abstract: A novel method has been developed for improved chemotherapy of animals infected with African trypanosomiasis. The method involves the concurrent administration of therapeutically effective amounts of cis-diamminedichloroplatinum (II) and bis-(diethylthiocarbamoyl)disulfide (disulfiram) or diethyl dithiocarbamate to the hydrated animal.
Type:
Grant
Filed:
April 3, 1981
Date of Patent:
July 30, 1985
Assignee:
The United States of America as represented by the Secretary of the Army
Abstract: Water soluble hydrogels of alkali metal alginate and glycerin containing 0.01 to 1% cupric (copper) sulfate pentahydrate or silver salts such as silver acetate, silver lactate monohydrate and silver nitrate have been found to be excellent wound dressing treatment composition for white phosphorus burns.Cupric sulfate pentahydrate or silver salts such as silver acetate, silver lactate monohydrate and silver nitrate in the gel reacts with the particles of white phosphorus to form a coating around said particles thus rendering them unable to cause further burn injury to the skin. The gels dry to an adherent, non-toxic pliable protective film which can be removed by water-washing when desired. The gels are also compatible with other medicaments and hence can serve as vehicles or carriers for medicament application to wounds as well as a protective cover.
Type:
Grant
Filed:
October 30, 1981
Date of Patent:
July 5, 1983
Assignee:
The United States of America as represented by the Secretary of the Army
Inventors:
Arthur D. Mason, Jr., Avery A. Johnson, Jr., Charles R. Ritchey