Patents Represented by Law Firm Jackson, Jackson & Chovanes
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Patent number: 4076816Abstract: The present invention relates to a new pharmaceutical composition with synergistic properties, to dosage units thereof, and to the use of the said composition and dosage units in the human or veterinary practice for the treatment of patients suffering from infectious diseases. The composition contains as active ingredients an amidinopenicillanic acid derivative of the formula ##STR1## in which R is hydrogen or a lower alkanoyloxymethyl radical including the pivaloyloxymethyl radical or atoxic salts thereof in combination with 2,4-diamino-5(3,4,5-trimethoxybenzyl)-pyrimidine, also known under the name trimethoprim, used hereinafter, or atoxic salts thereof.Type: GrantFiled: May 1, 1975Date of Patent: February 28, 1978Assignee: Leo Pharmaceutical Products Ltd. A/SInventor: Leif Tybring
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Patent number: 4072574Abstract: This involves an in vitro assay system to screen for mutagenic and/or carcinogenic agents based on alterations in the fidelity of DNA synthesis. In the system, chemicals will be tested for their mutagenicity or carcinogenicity by measuring increases in the number of mistakes incorporated by purified DNA polymerases using synthetic polynucleotide templates. This system offers the advantage of performing this analysis in the test tube so that all parameters in the reaction can be monitored. Agents that enhance misincorporation during DNA synthesis would be predicted to have a higher probability of being mutagens or carcinogens in the human population.Type: GrantFiled: July 30, 1976Date of Patent: February 7, 1978Assignee: The Institute for Cancer ResearchInventors: Lawrence A. Loeb, Michael A. Sirover
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Patent number: 4065331Abstract: This is a process and product in which excellent properties are achieved with a relatively low alloy steel and normal rolling with a steel having the following composition in addition to iron and impurities, in percentages by weight:______________________________________ Carbon .05 to .12 Manganese .25 to .90 Silicon .15 to .50 Nickel .15 to .50 Copper .15 to .50 Aluminum .02 to .110 Niobium (Columbium) .07 to .140 Nitrogen .007 to .015 Phosphorus .010 maximum Sulfur .025 maximum.Type: GrantFiled: October 8, 1976Date of Patent: December 27, 1977Assignee: Alan Wood Steel CompanyInventor: Frederick J. Semel
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Patent number: 4047784Abstract: A wire connector having an insulating body of S-shaped cross section wherein the bends of the S form wire-receiving channels. A pair of hinged and latched covers keep the wires in the channels. A metal contact plate is supported in the body and electrically connects the wires.Type: GrantFiled: December 28, 1976Date of Patent: September 13, 1977Assignee: Hollingsworth Solderless Terminal CompanyInventor: Robert D. Trank
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Patent number: 4033342Abstract: Nasal protection for the nostrils comprising a U-shaped wire-spring having an ellipsoidal-like nub fastened to each end for pressing the nostrils.Type: GrantFiled: September 5, 1975Date of Patent: July 5, 1977Inventor: Norman M. Lake
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Patent number: 4025961Abstract: A cape especially valuable for dealing with the hair made preferably of turkish toweling or in a particular case plastic, but suitably of various other materials, consisting of a shoulder-embracing portion, a slot for the head, two tongues surrounding the neck, there being curving lobes at the base of the tongues for overlapping on the chest or behind the shoulders. Special surface-type fasteners sit on the tongues near the end, and cooperating contact surface-type fastening places are near the top of the lobes. There are preferably also loops near the tops of the lobes which can surround the other tongues.Type: GrantFiled: December 12, 1975Date of Patent: May 31, 1977Inventor: Rita Moore Peters
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Patent number: 4022893Abstract: A treatment for hypertension by the conjoint use of phenoxybenzamine and propranolol, desirably with the conjoint use also of a diuretic.Type: GrantFiled: January 24, 1975Date of Patent: May 10, 1977Inventor: John H. Moyer
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Patent number: 4021637Abstract: In flux-cored wire electrodes for vertical automatic welding, from bottom to top, there is an electric arc under gaseous protection, the wires having diameters of 1 to 4 mm and generally shaped internally in any configuration, such as tubular, heart-shaped and composite, characterized by a sheath of steel strip, and a powdered filling flux most preferably including the following ingredients in qualitative and quantitative composition by powder weight:______________________________________ Iron powder 73% Silicofluoride of potassium (K.sub.2 SiF.sub.6) 4% Cryolite (Na.sub.3 AlF.sub.6) 2% Nickel powder 3% Ferro-molybdenum (at 65 up to 75%) 0.8% Refined ferromanganese (85 up to 90%) 9.9% Ferrosilicon (45%) 1% Ferrotitanium (30%) 0.5% Micaceous iron oxide 1% Fine silica 4% Silicocalcium (SiCa) 0.8% 100.0% ______________________________________The flux-cored wires most preferably have a filling coefficient of 32 grams of powder weight per 100 grams of strip.Type: GrantFiled: August 29, 1975Date of Patent: May 3, 1977Assignee: La Soudure Electrique Autogene, Procedes ArcosInventor: Robert J. DeHaeck
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Patent number: 4008365Abstract: The invention relates to single, paired opposite phased and multiple stacked insulated flexible or rigid bus bar electrical conductors of copper or aluminum assembled side by side (optionally in a factory or at installation site) as high current density circuits into open trays of substantial length and covers to totally enclose a heat transfer tray co-extensive with the tray and having clamps extending across the tray to secure the cover to the tray and urging the cover upon conductors or conductor joints in the tray by tightening single bolts per clamp. Also, the invention involves making externally operable end to end overlap compression circuit joints of bus bar conductors simultaneously with one or more single bolt clamps for each single, paired phase and multiple stack, electrically insulated apart and supported within the metal tray.Type: GrantFiled: March 3, 1975Date of Patent: February 15, 1977Assignee: Broadhill Development CorporationInventor: Elmer T. Carlson
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Patent number: 3972886Abstract: Compounds of the general formula ##SPC1##In which R.sub.1 represents a straight or branched C.sub.1 -C.sub.6 alkyl, alkenyl or alkynyl radical, or a C.sub.1 -C.sub.3 alkyl radical substituted with phenyl, halophenyl, trifluoromethylphenyl, (lower alkoxy)phenyl, or with a 5-membered or 6-membered heterocyclic ring containing not more than two heteroatoms selected from the group consisting of oxygen, sulphur and nitrogen; R.sub.2 stands for a phenyl radical, optionally being substituted with halogen, lower alkyl, hydroxy, or lower alkoxy; X and Y stand for oxygen or sulphur; their salts and esters and methods for their preparation. The compounds of the invention possess an outstanding diuretic and saluretic activity with a very low excretion of potassium ions and a low toxicity.Type: GrantFiled: March 17, 1975Date of Patent: August 3, 1976Assignees: Leo Pharmaceutical Products Ltd., A/S Lovens Kemiske Fabrik ProduktionsakieselskabInventors: Peter Werner Feit, Ole Bent Tvaermose Nielsen, Herta Bruun
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Patent number: 3969210Abstract: The invention comprises an improved electrolytic cell of the Keidel type, U.S. Pat. No. 2,830,945, in which the original set of electrodes is replaced by two sets having a ratio of length of not less than 3 to 1 and having independent terminals and independent bodies coupled together. The invention also may comprise potting the element including the longer set of electrodes and leaving the element including the shorter set of electrodes unpotted.Type: GrantFiled: April 21, 1975Date of Patent: July 13, 1976Inventor: Gustav Bergson
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Patent number: 3957764Abstract: The invention relates to hitherto unknown derivatives of 6-aminopenicillanic acids of the formula ##SPC1##In which R.sub.1 and R.sub.2 are similar or different aliphatic, cycloaliphatic, aromatic or heterocyclic substituents linked directly or through alkyl groups to the nitrogen atom, or R.sub.1 and R.sub.2 together with the nitrogen atom form a heterocyclic ring, and R.sub.3 is a hydroxyl or substituted hydroxyl group; to pharmaceutically acceptable salts, and to methods for producing these new compounds having a strong antibacterial effect, especially on gram-negative bacteria, to pharmaceutical preparations in dosage unit forms containing the compounds of the invention solely, or in synergistic mixtures with penicillins, and to methods of treating patients with the dosage units.Type: GrantFiled: November 6, 1972Date of Patent: May 18, 1976Assignee: Lovens Kemiske Fabrik ProduktionsaktieselskabInventor: Frantz Johannes Lund
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Patent number: 3956279Abstract: The present invention relates to pivaloyloxymethyl D(-)-.alpha.-aminobenzylpenicillinate of the formula I in a novel and improved form, i.e. the crystalline form ##SPC1##To methods of producing said crystalline pivaloyloxymethyl D(-)-.alpha.-aminobenzylpenicillinate and to pharmaceutical preparations containing said crystalline pivaloyloxymethyl D(-)-.alpha.-aminobenzylpenicillinate.Crystalline pivaloyloxymethyl D(-)-.alpha.-aminobenzylpenicillinate has no bitter taste, is only slightly soluble in water, and is stable and readily absorbable.Type: GrantFiled: September 21, 1973Date of Patent: May 11, 1976Assignee: Leo Pharmaceutical Products Ltd.Inventors: Ernst Torndal Binderup, Hans Jorgen Petersen, Sven Liisberg
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Patent number: 3954735Abstract: The invention relates to a series of new compounds, to salts of these compounds and to methods for the preparation of the compounds. The new compounds have the general formula: ##EQU1## in which n is an integer from 0 to 5; and A is selected from the group consisting of an unsubstituted or substituted aliphatic, alicyclic, aromatic and heterocyclic radical.The compounds of the invention are broad-spectrum antibiotics especially usable for oral administration.Type: GrantFiled: June 7, 1971Date of Patent: May 4, 1976Assignee: Lovens kemiske Fabrik ProduktionsaktieselskabInventor: Welf von Daehne
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Patent number: 3953141Abstract: The invention relates to a new lock for the inner race of a self-aligning bushing to a shaft.Type: GrantFiled: February 27, 1975Date of Patent: April 27, 1976Assignee: Roller Bearing Company of AmericaInventor: Hans W. Koch
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Patent number: 3950376Abstract: Compounds of the general formula ##SPC1##In which R.sub.1 represents a straight or branched C.sub.1 -C.sub.6 alkyl, alkenyl or alkynyl radical, or a C.sub.1 -C.sub.3 alkyl radical substituted with phenyl, halophenyl, trifluoromethylphenyl, (lower alkoxy)phenyl, or with a 5-membered or 6-membered heterocyclic ring containing not more than two heteroatoms selected from the group consisting of oxygen, sulphur and nitrogen; R.sub.2 stands for a phenyl radical, optionally being substituted with halogen, lower alkyl, hydroxy, or lower alkoxy; X and Y stand for oxygen or sulphur; their salts and esters and methods for their preparation.The compounds of the invention possess an outstanding diuretic and saluretic activity with a very low excretion of potassium ions and a low toxicity.Type: GrantFiled: June 18, 1973Date of Patent: April 13, 1976Assignee: Leo Pharmaceutical Products Ltd. A/SInventors: Peter Werner Feit, Ole Bent Tvaermose Nielsen, Herta Bruun
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Patent number: 3948246Abstract: The invention concerns heaters, particularly for sports benches and more especially for the benches on which substitute players of the team sit during games. In the preferred form, a self-contained heater such as a combustion operated construction heater with blower produces the heat behind the bench, and the heat is conducted through a conduit into the space beneath the bench, and then through a T-conduit in either direction to points from which it is distributed. The space beneath the bench confines the heat on the front, back, sides and bottom. Heat is distributed through openings in the top of the bench toward the back, and also through openings in the front of the bench, which may be at the top of the front of the bench and at the bottom of the bench. In a less preferred embodiment, heaters may be in spaces continuous with the bench.Type: GrantFiled: July 17, 1974Date of Patent: April 6, 1976Inventor: John F. Jenkins
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Patent number: 3947215Abstract: The method of burning fume, including combustible gases and gas-borne particles, comprising moving the fume in a tube having a blind end and one or more slits in the tube short of the end, while the fume is at least partially at ignition temperature, and emitting the fume into the air, the slit width and the slit total area being chosen such that the fume velocity through the slits will be more than the flame velocity and up to the flame blow-out velocity. The device includes a tube having a closed end and slits having a width between one-eighth and 1 inch and preferably about five-eighths inch, and a length of between one-eighth and one-half of the circumference.Type: GrantFiled: January 7, 1975Date of Patent: March 30, 1976Assignee: Aluminum Company of AmericaInventors: Richard W. Peterson, L. Graydon Carpenter, Raymond Kastelic
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Patent number: 3941551Abstract: A dual outlet extrusion flat film die assembly for various thermo-extrudable materials includes split manifold chambers separated from each other by a rigid centerplate. Each portion of the die in the direction behind the flow materials includes a heat sink slot behind the manifold. Each manifold tapers toward its own die mouth; has separate melt inlets adapted for center, top or end feed operations; has separate pre-land and final land surfaces leading to individual outlet openings for precise control of melt flow; and has separate heat control means allowing precise temperature control for each melt as it flows throughout the die. Temperature differentials ranging from O.degree. to 200.degree.F. are obtainable between the extruded layers. A differential push-pull adjustment system for each movable lip of each outlet opening includes opposed alternatingly staggered thimble bolts to precise control of each individual layer profile.Type: GrantFiled: January 22, 1974Date of Patent: March 2, 1976Inventor: George J. Marion
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Patent number: 3941550Abstract: A multiple outlet flat film die apparatus and process which extrude separate streams of material to form any of various composites which may involve joining of similar or dissimilar materials, which includes individual manifold chambers separated from each other by heat insulating means inbetween. The heat insulating means in between such as for example heat insulating material between plates retards heat transfer between the materials. Each manifold is tapered toward its own die mouth; has separate melt inlets adapted for center, top and/or end feed operations; has separate pre-land and final land surfaces leading to individual outlet openings for precise control of melt flow; and has separate heat control means allowing precise temperature control for each melt as it flows toward the die. Temperature differentials may be extensive and may approach the difference between the original temperature of the melt delivered to each manifold. Heat differentials of 0.degree. to 200.degree.F. are an example.Type: GrantFiled: January 22, 1974Date of Patent: March 2, 1976Inventor: George J. Marion