Patents Represented by Attorney Jacob M. Levine
  • Patent number: 6165999
    Abstract: The present invention relates to novel tetracycline derivatives, to intermediates used in their preparation, to pharmaceutical compositions containing them and to their medicinal use.
    Type: Grant
    Filed: February 23, 1998
    Date of Patent: December 26, 2000
    Assignee: Pfizer Inc
    Inventor: Chi Bao Vu
  • Patent number: 6077886
    Abstract: A curable epoxy resin composition comprising (A) an epoxy resin, (B) a thixotropic agent in an amount sufficient to induce thixotropic properties, and a hardener comprising (C) at least one polyethyleneimine and (D) at least one other amine having at least 2 amino hydrogen atoms, the combined amounts of (C) and (D) being sufficient to effect cure of the epoxy resin.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: June 20, 2000
    Assignee: Ciba Specialty Chemicals Corpation
    Inventors: Barry James Hayes, Kevin Brian Hatton
  • Patent number: 6077891
    Abstract: Damaged thermoplastics can be outstandingly stabilized by the use of a mixture comprising a) 0.05 to 20% by weight, based on the plastic to be stabilized, of at least one polyfunctional epoxide, b) 0.01 to 2% by weight, based on the plastic to be stabilized, of at least one sterically hindered phenol.
    Type: Grant
    Filed: August 27, 1997
    Date of Patent: June 20, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Heinz Herbst, Kurt Hoffmann, Rudolf Pfaendner
  • Patent number: 6046304
    Abstract: Compounds of the formula (I) ##STR1## in which the polydispersity Mw/Mn is 1; n is 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15; the radicals R.sub.1 are for example hydrogen or C.sub.1 -C.sub.8 alkyl; R.sub.2 is for example C.sub.2 -C.sub.12 alkylene; the radicals A are independently of one another --OR.sub.3, --N(R.sub.4)(R.sub.5) or a group of the formula ##STR2## R.sub.3, R.sub.4 and R.sub.5, which are identical or different, are for example hydrogen or C.sub.1 -C.sub.18 alkyl,or --N(R.sub.4)(R.sub.5) is additionally a group of the formula ##STR3## with Y being --O--, --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- or >N--CH.sub.3 ; X is --O-- or >N--R.sub.6 ; R.sub.6 is for example hydrogen or C.sub.1 -C.sub.18 alkyl; R is preferably a group of the formula ##STR4## and the radicals B have independently of one another one of the definitions given for A; with the proviso that in the individual recurrent units of the formula (I), each of the radicals B, R, R.sub.1 and R.sub.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: April 4, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Valerio Borzatta, Fabrizio Guizzardi
  • Patent number: 6020406
    Abstract: A synergistic stabilizer mixture comprising a component a) and, for example, a component b), where component a) is at least one compound of the formula I ##STR1## in which R.sub.1 is C.sub.1 -C.sub.10 alkyl, C.sub.5 -C.sub.12 cycloalkyl, C.sub.1 -C.sub.4 alkyl-substituted C.sub.5 -C.sub.12 cycloalkyl, phenyl or C.sub.1 -C.sub.10 alkyl-substituted phenyl,R.sub.2 is C.sub.3 -C.sub.10 alkylene,R.sub.3 is hydrogen, C.sub.1 -C.sub.8 alkyl, O.sup..cndot., --CH.sub.2 CN, C.sub.3 -C.sub.6 alkenyl, C.sub.7 -C.sub.9 phenylalkyl, C.sub.7 -C.sub.9 phenylalkyl which is substituted on the phenyl radical by C.sub.1 -C.sub.4 alkyl; or C.sub.1 -C.sub.8 acyl, andn.sub.1 is a number from 1 to 50,and component b) is, for example, a compound of the formula ##STR2## in which n.sub.2 is a number from 2 to 20.
    Type: Grant
    Filed: May 27, 1997
    Date of Patent: February 1, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventor: Fran.cedilla.ois Gugumus
  • Patent number: 6015849
    Abstract: A synergistic stabilizer mixture comprising a component a) and, for example, a component b), where component a) is at least one compound of the formula I ##STR1## in which R.sub.1 is hydrogen or methyl, R.sub.2 is a direct bond or C.sub.1 -C.sub.10 alkylene, and n.sub.1 is a number from 2 to 50; component b) is at least one compound of the formulae IIa and IIb ##STR2## in which n.sub.2 and n.sub.2 * are a number from 2 to 50.
    Type: Grant
    Filed: April 21, 1997
    Date of Patent: January 18, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventor: Fran.cedilla.ois Gugumus
  • Patent number: 6015504
    Abstract: The present invention relates to new compounds which are useful as ultraviolet absorbing agents (UVAs) and as fluorescent whitening agents (FWAs), and to a method of improving the sun protection factor (SPF) of textile fiber material, especially cotton, polyamide and wool, treated with the new compounds and with certain known compounds.
    Type: Grant
    Filed: January 26, 1998
    Date of Patent: January 18, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Dieter Reinehr, Claude Eckhardt, Robert Hochberg, Werner Kaufmann, Georges Metzger
  • Patent number: 6008357
    Abstract: A process for resolving 1-azabicyclo[2.2.2]octan-3-amine, (2-diphenylmethyl)-N-[[2-methoxy-5-(1-methylethyl)phenyl]methyl] in which 1-azabicyclo[2.2.2]octan-3-amine, (2-diphenylmethyl)-N-[[2-methoxy-5-(1-methylethyl)phenyl]methyl] is reacted with 1R-(-)-10-camphorsulfonic acid in a solvent capable of dissolving both the foregoing reactants and selectively dissolving the camphorsulfonic acid salt of the corresponding (2R, 3R) enantiomer relative to the (2S, 3S) enantiomer.
    Type: Grant
    Filed: December 16, 1997
    Date of Patent: December 28, 1999
    Assignee: Pfizer Inc
    Inventors: Derek L. Tickner, Morgan Meltz
  • Patent number: 6005109
    Abstract: The pyrazoles and pyzazolopyrimidines of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and A are as defined herein, have corticotropin releasing factor (CRF) antagonist activity. As such, they are effective In the treatment of a wide range of diseases including stress-related illnesses.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: December 21, 1999
    Assignee: Pflizer Inc.
    Inventors: William Stephen Faraci, Willard McKowan Welch, Jr.
  • Patent number: 5997627
    Abstract: The disclosure describes pigment compositions containing a small particle size porous filler and a pigment, and their use for preparing effect coating compositions which produce thin film finishes exhibiting strong lightness and color flop with a pronounced three dimensional effect. The thin film finishes are particularly interesting as automotive finishes.
    Type: Grant
    Filed: November 12, 1997
    Date of Patent: December 7, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventor: Fridolin Babler
  • Patent number: 5997587
    Abstract: Dye mixtures comprising at least one dye of the formula (1) ##STR1## together with at least one dye of the formula (2) or (3) ##STR2## in which the substituents are as defined in claim 1 are direct dyes for cellulosic fibre materials in particular. They are stable at high temperatures and are particularly suitable for the one-bath, single-stage dyeing of polyester/cotton blends with a disperse dye for the polyester fibres under the dyeing conditions for polyester fibres.
    Type: Grant
    Filed: March 11, 1998
    Date of Patent: December 7, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventor: Urs Lauk
  • Patent number: 5989297
    Abstract: Dye mixtures comprising at least one compound of the formula ##STR1## and at least one compound of the formula ##STR2## in which the variables are as defined in the claims,which are suitable as fibre-reactive dyes for dyeing widely varying fibre materials, are described.
    Type: Grant
    Filed: July 15, 1996
    Date of Patent: November 23, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Hans Reichert, Bernhard Muller, Athanassios Tzikas
  • Patent number: 5983678
    Abstract: The present invention relates to a process for the continuous dyeing of cellulose fiber yarns with reactive dyes and to an apparatus for carrying out this process.The process essentially comprises steps of impregnating yarn which has been continuously unwound at high speed from one or several supports (1) and rewound onto one or several supports (3) with at least one fiber-reactive dye in aqueous solution and at least one alkaline reagent in aqueous solution, and fixing the dye.The invention can be applied especially in the technical field of dyeing cellulose fibers.
    Type: Grant
    Filed: May 4, 1998
    Date of Patent: November 16, 1999
    Assignees: Ciba Specialty Chemicals Corporation, Superba
    Inventors: Robert Enderlin, Mickael Mheidle, Didier Thibault
  • Patent number: 5985912
    Abstract: Compounds of the formula The compounds are useful in the treatment of bacterial infections.
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: November 16, 1999
    Assignee: Pfizer Inc.
    Inventors: Bingwei Yang, Joyce Sutcliffe, Chris J. Dutton
  • Patent number: 5976238
    Abstract: Pigment powder mixtures, consisting of0.999-0.5 part of C.I. Pigment Yellow 184, and0.001-0.5 part of an organic pigment selected from the group consisting of C.I. Pigment Orange 13, C.I. Pigment Orange 34, C.I. Pigment Orange 36, C.I. Pigment Orange 73, C.I. Pigment Red 170, C.I. Pigment Red 254, C.I. Pigment Red 255 and C.I. Pigment Red 264,or of0.99-0.5 part of C.I. Pigment Yellow 184, and0.01-0.5 part of an organic pigment selected from the group consisting of C.I. Pigment Yellow 83, C.I. Pigment Yellow 110 and C.I. Pigment Yellow 139.These pigment powder mixtures are distinguished, in particular in paints, by very high chroma.
    Type: Grant
    Filed: June 16, 1997
    Date of Patent: November 2, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Leonardus Johannes Hubertus Erkens, Gregor Schmitt, Hendrikus Maria Anna Hamers, Johannes Maria Martinus Luijten, Jozef Gertruda Emanuel Mains
  • Patent number: 5977357
    Abstract: A novel process for the preparation of compounds of formula I ##STR1## by aminolysis of a p-halophenyl alkyl ketone of formula II ##STR2## with a cyclic amine of formula III ##STR3## in water at a temperature of at least 130.degree. C., in which formulae X is a halogen atom and R.sub.1, R.sub.2 and R.sub.3 are as claimed in claim 1, as well as the novel compounds of formula I and their use for the preparation of photoinitiators for the photopolymerisation of ethylenically unsaturated compounds.
    Type: Grant
    Filed: June 1, 1998
    Date of Patent: November 2, 1999
    Assignee: Ciba Specialty Chemical Corporation
    Inventors: Rinaldo Husler, Rudolf Schwabe, Reto Luisoli
  • Patent number: 5973147
    Abstract: Process for dichromatic or trichromatic dyeing or printing of natural or synthetic polyamide fibre material, which comprises using at least one blue-dyeing fibre-reactive anthraquinone dye of the formula ##STR1## in which R.sub.1 and R.sub.2 independently of one another are hydrogen or substituted or unsubstitutedC.sub.1 -C.sub.12 alkyl,X.sub.1 is halogen,B.sub.1 is an organic bridge member andV.sub.1 is an aliphatic or aromatic amine containing a fibre-reactive group,together with at least one fibre-reactive sulfo group containing yellow- or orange-dyeing dye ortogether with at least one fibre-reactive sulfo group containing red-dyeing dye. Level dyeings with good fastness properties are obtained.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: October 26, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Urs Lehmann, Marcel Frick, Klaus Hannemann
  • Patent number: 5969154
    Abstract: A liquid crystalline compound of formula ##STR1## wherein B and D are each independently of the other C.sub.6 -C.sub.24 alkyl, ##STR2## L is ##STR3## methyl or C.sub.10 -C.sub.18 alkyl, wherein R.sub.1 is C.sub.4 -C.sub.18 alkyl, with the proviso that when L is methyl, at least one of B and D is C.sub.6 -C.sub.24 alkyl;R2 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halogen, cyano or nitro,R3, R4 and R5 are each independently of one another hydrogen, OR6, SR6, SeR6, --NHR6, --NR6R7, ##STR4## with the proviso that at least one of R3, R4 and R5 is not hydrogen, R6 is C.sub.7 -C.sub.37 alkyl, C.sub.7 -C.sub.37 alkylene or C.sub.5 -C.sub.18 alkyl which is interrupted by 1 to 6 hetero atoms selected from the group consisting of O, S and N,R7 is hydrogen or R9,R8 is hydrogen or C.sub.1 -C.sub.4 alkyl, andR9 is C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.12 alkylene or C.sub.3 -C.sub.12 alkyl which is interrupted by 1 to 6 hetero atoms selected from the group consisting of O, S and N.
    Type: Grant
    Filed: December 10, 1997
    Date of Patent: October 19, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Zhimin Hao, Abul Iqbal, Nancy Tebaldi, Klaus Praefcke
  • Patent number: 5969113
    Abstract: Compounds of the formula ##STR1## in which the variables are as defined in the claims, which are suitable as fibre-reactive dyes for dyeing widely varying fibre materials, are described.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: October 19, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Rolf Deitz, Bernhard Muller, Athanassios Tzikas
  • Patent number: 5965745
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 AND R.sup.2 are as defined, useful in the treatment of asthma, rheumatoid arthritis, osteoarthritis, bronchitis, chronic obstructive airways diseases, psoriasis, allergic rhinitis, atopic dermatitis, shock, and other inflammatory diseases and for blocking the leucotriene D4 receptor, pharmaceutical compositions containing such compounds and methods of blocking leucotriene D4 receptors using such compositions.
    Type: Grant
    Filed: July 1, 1998
    Date of Patent: October 12, 1999
    Assignee: Pfizer Inc
    Inventors: Matthew F. Brown, Anthony Marfat