Abstract: A system and method for detecting bio-hazardous particulates in mail handling systems includes an air intake hood 20 that connects to a biohazard sensing suite 24 which, in turn, connects through an outlet duct 26 to a filter, adsorber, or scrubber 28 that removes any bio-hazardous material prior to exhausting the air. An air mover 30 is located in the outlet duct 26 and moves the air into the air intake hood 20 into the biohazard sensing suite 24. The biohazard sensing suite 24 detects the presence of any undesired bio-hazardous material.