Abstract: Phosphorothioate oligodeoxyribonucleotide analogs can be used to prevent replication of foreign nucleic acids in the presence of normal living cells, as well as to inhibit the proliferation of neoplastic cells.

Abstract: A method and apparatus for improving the performance of a thermal breeder reactor having regions of higher than average moderator concentration are disclosed. The fuel modules of the reactor core contain at least two different types of fuel elements, a high enrichment fuel element and a low enrichment fuel element. The two types of fuel elements are arranged in the fuel module with the low enrichment fuel elements located between the high moderator regions and the high enrichment fuel elements. Preferably, shim rods made of a fertile material are provided in selective regions for controlling the reactivity of the reactor by movement of the shim rods into and out of the reactor core. The moderation of neutrons adjacent the high enrichment fuel elements is preferably minimized as by reducing the spacing of the high enrichment fuel elements and/or using a moderator having a reduced moderating effect.

Abstract: An electrochemical polishing device and method for selective anodic dissolution of the surface of test specimens comprised, for example, of nickel-chromium-iron alloys, which provides for uniform dissolution at the localized sites to remove metal through the use of a coiled wire electrode (cathode) placed in the immediate proximity of the working, surface resulting in a polished and uniform grain boundary.

Abstract: A quick-sealing assembly and method for forming an adhesive seal on opposite sides of a mechanical seal for a flexible containment bag of the type used for working with radioactively contaminated objects. The assembly includes an elongated mechanical fastener having opposing engaging members affixed at a predetermined distance from each of the elongated edges, with an adhesive layer formed between the mechanical fastener and the elongated edge such that upon engagement of the mechanical fastener and adhesive layers to opposing containment fabric, a neat triple hermetic seal is formed.

Abstract: A self-locking washer made of a flat elongated piece of material having a slot in one end of it. The washer is designed so that it can be placed underneath bolts or nuts which are already installed without completely removing the bolt or nut. A method of use of the self-locking washer is also disclosed.

Abstract: A vehicle security barrier which can be conveniently placed across a gate opening as well as readily removed from the gate opening to allow for easy passage. The security barrier includes a barrier gate in the form of a cable/gate member in combination with laterally attached pipe sections fixed by way of the cable to the gate member and lateral, security fixed vertical pipe posts. The security barrier of the present invention provides for the use of cable restraints across gate openings to provide necessary security while at the same time allowing for quick opening and closing of the gate areas without compromising security.

Abstract: A solid pharmaceutical composition suitable for oral or rectal administration comprising a unit dosage of a pharmaceutically active ingredient (and optionally one or more inert fillers) homogeneously dispersed in a pharmaceutically acceptable binder, wherein at least a major portion (i.e., at least 50% by weight) of the binder is a microcrystalline solid phase prepared by raising the pH of a dairy whey lactose permeate having a pH below about 7 to a pH between about 8 and 10 to form (i) a lactose-rich aqueous solute phase capable of being autoclaved for 10-20 minutes at 121.degree. C.

Abstract: A new use of dehydroepiandrosterone sulfate or its salt as a parturient canal conditioning agent is disclosed.The maturity of the parturient canal and the sensitivity of uterine musculature to oxytocin are improved resulting in normal parturition by administering to a pregnant human subject at the 37th to 39th week of pregnancy a therapeutically effective amount of dehydroepiandrosterone sulfate or its pharmaceutically acceptable salts such as the sodium salt.

Abstract: A new and useful 1-N-[(S)-.alpha.-hydroxy-.omega.-aminoacyl]derivative of an aminoglycosidic antiobiotic, including its deoxy derivative, such as kanamycin B, 3'-deoxyneamine, 3',4'-dideoxyneamine, 3',4'-dideoxyribostamycin or 3', 4'-dideoxykanamycin B is now synthetized from the parent substance, aminoglycosidic antibiotic. The new 1-N-[(S)-.alpha.-hydroxy-.omega.-aminoacyl] derivative shows a wider and/or higher antibacterial activity than the parent substance and is useful in the treatment of infections by gram-negative and gram-positive bacteria, including drug-resistant strains thereof. The preparation of this new derivative may be made by 1-N-acylating the parent aminoglycosidic antibiotic with (S)-.alpha.-hydroxy-.omega.-aminocarboxylic acid with the amino group being protected, and chromatographically separating the acylated products to isolate the desired 1-N-acyl derivative, followed by the removal of the amino-protecting group.

Abstract: A pilot-controlled electromagnetic valve having a pilot valve mounted on a member which is supported movably relative to a solenoid plunger and a main valve and connected to the plunger through a spring such that a pilot orifice is opened when the plunger approaches a fixed core of the solenoid undergoing a stronger magnetic pull.

Abstract: A process for diagnosing Chagas' disease in a living mammal susceptible to infection by Trypanosoma cruzi which comprises reacting in vitro an antibody-containing blood sample from said mammal in an immunoprecipitin test with an immunologically effective amount of a purified water-soluble antigen extract obtained from essentially only the trypomastigote and amastigote growth stages of the protozoa Trypanosoma cruzi, and diagnosing the presence of Chagas' disease from the formation of precipitin bands at an antigen-antibody interface.

Abstract: Wool fatty acid is effectively separated from wool alcohol or wool wax by treating a mixture of a multivalent metal soap of the fatty acid and the alcohol or wax with a heterogeneous system comprising a water phase and a water-immiscible solvent phase, and allowing the system to separate into respective phases.

Abstract: Complex enzymes which can lyse the cell wall of a variety of microorganisms such as bacteria, fungi, yeast, Basidiomycetes and chlorella are produced and recovered from cultivation of Pellicularia sasakii or Pellicularia filamentosa.

Abstract: A new cyclic ureido-derivative of a deoxystreptamine-containing antibiotic represented by the general formula: ##SPC1##Wherein R.sub.a, R.sub.b and R.sub.c stand for the residues present in the molecule of said antibiotic other than the deoxystreptamine moiety thereof is produced.

Abstract: A new process of producing a 2-(4-alkylphenyl)-propionic acid known as a valuable anti-inflammatory agent is now provided, which comprises treating an alkyl 3-methyl-3-(4-alkylphenyl)-glycidate with an acid to produce 2-(4-alkylphenyl)-propionaldehyde and 3-methyl-3-(4-alkylphenyl)-pyruvic acid through a new reaction, and then oxidising these intermediate products to the desired 2-(4-alkylphenyl)-propionic acid. This new process is operable in a facile way, gives a high yield of the desired product and is suitable for a commercial practice.

Abstract: A membrane separation apparatus adapted for use in ultrafiltration is provided comprising a casing and a membrane unit enclosed therein, said membrane unit comprising a composite membrane folded flatly in zigzag relation to form a plurality of stacked layers defining a plurality of first flow channels in alternately interleaving relation thereto, said composite membrane being made of a flexible porous support and having a pair of selectively permeable membranes on opposite outer surfaces thereof and a second flow channel therebetween.

Abstract: New compounds of the formula ##SPC1##Wherein Ar is selected from the group consisting of phenylethyl, furyl, methylfuryl, thienyl, pyrrolyl, naphthyl, hydroxynaphthyl, and phenyl substituted by at least one member selected from the group consisting of halogen, hydroxyl, cyano, trifluoromethyl, akyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, carbamoyl, amino of the formula --NR'R", alkoxycarbonyl of the formula --CO--OR' wherein R'and R"are each alkyl of 1-4 carbon atoms, and alkylenedioxy of the formula --O--R '"--O-- wherein R'" is alkylene of 1-4 carbon atoms, provided that said substituted phenyl is not 3,4-di-methoxyphenyl, and the addition salts thereof with the cation of an organic or inorganic base inhibit the enzyme activities of tyrosine hydroxylase and dopamine .beta.-hydroxylase and are useful chemotherapeutic agents in the treatment of essential hypertension.

Abstract: A new process for the production of a 2-(4-alkylphenyl)-propionic acid known as a valuable anti-inflammatory agent is now provided, which comprises treating an alkyl 2-hydroxy-3-(4-alkylphenyl)-3-butenoate, a new compound, with an alkali metal alcoholate in an alcohol to give the corresponding alkyl 3-methyl-3-(4-alkylphenyl)-pyruvate, also a new compound, which is then hydrolysed to liberate the corresponding 3-methyl-3-(4-alkylphenyl)-pyruvic acid, and then oxidising the liberated pyruvic acid compound to the desired 2-(4-alkylphenyl)-propionic acid. This new process is operable in a facile way with a high yield of the desired product and is much suitable for a commercial practice than the prior art methods.

Abstract: Lividomycin B derivatives having enhanced antibacterial activity are provided; the 6'-deoxy-6' substituted or unsubstituted amino lividomycins are prepared by masking the functional groups other than the 4' - and 6' -hydroxyl groups, converting the 6' hydroxyl group to an amino group and then removing the remaining protective groups.

Abstract: A poppet type change-over valve assembly suitable for switching a fluid flow direction and capable of dealing with a large fluid flow with a small valve displacement and small valve operating force. The valve assembly characteristically comprises an annular float valve which is loosely mounted around a main valve body and has parallel or concentric outer and inner sealing edges for engagement with conical valve seats which are formed on the main valve body and an inner wall surface of the valve casing. The annular float valve is adapted to be tightly held between the conical valve seats of the main valve body and the valve casing by cooperation of the main valve body and a fluid pressure prevailing in the valve chamber when the valve is switched to a desired change-over position thereby establishing a tight seal around the main valve body for connecting a fluid inlet port with a selected fluid output port of the valve.