Patents Represented by Attorney James Epperson

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  • 3-thia-4-arylquinolin-2-one derivatives
    Patent number: 7145013
    Abstract: This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome
    Type: Grant
    Filed: October 13, 2004
    Date of Patent: December 5, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventor: Kenneth M. Boy
  • HIV integrase inhibitors
    Patent number: 7135467
    Abstract: Compounds useful for treating HIV are disclosed having the general formula wherein R1, R2, and B are as defined in the specification. Compositions containing the compounds and methods for using the compounds to inhibit HIV are also disclosed.
    Type: Grant
    Filed: January 12, 2004
    Date of Patent: November 14, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael A. Walker, Hatice Belgin Gulgeze, Narasimhulu B. Naidu, Margaret E. Sorenson, Yasutsugu Ueda, John Matiskella
  • Compounds for the treatment of male erectile dysfunction
    Patent number: 7132542
    Abstract: This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome.
    Type: Grant
    Filed: October 13, 2004
    Date of Patent: November 7, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventor: Kenneth M. Boy
  • Cycloalkyl heterocycles for treating hepatitis C virus
    Patent number: 7112601
    Abstract: Compounds of Formula I are disclosed which inhibit hepatitis C NS5B RNA-dependent RNA polymerase and are useful for treating hepatitis C.
    Type: Grant
    Filed: August 19, 2004
    Date of Patent: September 26, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Peter W. Glunz, Brent D. Douty, Scott W. Martin, Jeffrey Romine
  • HIV integrase inhibitors
    Patent number: 7109186
    Abstract: The present invention describes novel compounds of Formula I which inhibit HIV integrase.
    Type: Grant
    Filed: July 9, 2003
    Date of Patent: September 19, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael A. Walker, Zhuping Ma, B. Narasimhulu Naidu, Margaret E. Sorenson, Annapurna Pendri, Jacques Banville, Serge Plamondon, Roger Remillard
  • Compounds for the treatment of premature ejaculation
    Patent number: 7105516
    Abstract: The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salts or solvates thereof and pharmaceutically acceptable formulations comprising said compounds useful for the treatment of premature ejaculation, depression, attention deficit hyperactivity disorder, obsessive-compulsive disorder, post-traumatic stress disorder and substance abuse disorders.
    Type: Grant
    Filed: September 15, 2003
    Date of Patent: September 12, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Derek John Denhart, Jonathan L. Ditta, Dalton King, John E. Macor, Lawrence R. Marcin, Ronald J. Mattson, Zhaoxing Meng
  • 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators
    Patent number: 7091202
    Abstract: The invention encompasses compounds of Formula I, which are blockers of KCNQ channels. Blockers of KCNQ channels are known to enchance cognition in laboratory animals.
    Type: Grant
    Filed: September 8, 2005
    Date of Patent: August 15, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kevin W. Gillman, Dharmpal S. Dodd, John E. Starrett, Jr., Danielle Bocchino
  • Benzothiazole antiviral agents
    Patent number: 7087610
    Abstract: The invention encompasses a series of benzothiazole compounds which inhibit HIV entry and are useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for using these compounds.
    Type: Grant
    Filed: May 9, 2005
    Date of Patent: August 8, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Tao Wang, John F. Kadow, Nicholas A. Meanwell
  • Antiamyloid phenylsulfonamides: N-cycloalkylcarboxamides derivatives
    Patent number: 7084178
    Abstract: A series of N-cycloalkylcarboxamide derivatives of N-benzyl benzenesulfonamides of Formula I are described. The compounds inhibit ?-amyloid peptide (?-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions characterized by aberrant extracellular deposition of ?-amyloid. Pharmaceutical compositions and methods of treatment using these compounds are also disclosed.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: August 1, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Lawrence R. Marcin, Mendi A. Higgins
  • Cyclopentyl indole derivatives
    Patent number: 7049314
    Abstract: The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salts or solvates thereof and pharmaceutically acceptable formulations comprising said compounds useful for the treatment of premature ejaculation, depression, attention deficit hyperactivity disorder, obsessive-compulsive disorder, post-traumatic stress disorder and substance abuse disorders.
    Type: Grant
    Filed: September 15, 2003
    Date of Patent: May 23, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Dalton King, Jeffrey A. Deskus, John E. Macor, Ronald J. Mattson, Zhaoxing Meng, Charles P. Sloan
  • 3-Thia-4-arylquinolin-2-one potassium channel modulators
    Patent number: 7049309
    Abstract: This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome.
    Type: Grant
    Filed: October 13, 2004
    Date of Patent: May 23, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kenneth M. Boy, Piyasena Hewawasam, Sing-Yuen Sit, Kai Xie
  • Amidoheterocycles as modulators of the melanocortin-4 receptor
    Patent number: 7049323
    Abstract: Novel azetidinyl and pyrrolidinyl compounds are ligands of melanocortin-4 receptors and are useful for treating conditions responsive to the modulation of melanocortin-4 receptors such as obesity, diabetes, and sexual dysfunction.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: May 23, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Prasad V. Chaturvedula, Guanglin Luo, Shikha Vig, Graham S. Poindexter, Brett R. Beno
  • HIV integrase inhibitors
    Patent number: 7037908
    Abstract: The present invention relates to a series of pyrimidine compounds of Formula I which inhibit HIV integrase and to pharmaceutical compositions and methods of treatment for AIDS or ARC using these compounds
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: May 2, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: B. Narasimhulu Naidu, Michael A. Walker, Margaret E. Sorenson
  • Substituted benzimidazole antiviral agents
    Patent number: 7030140
    Abstract: The present invention concerns antiviral compounds, their compositions, and use in the treatment of viral infections. More particularly, the invention provides benzimidazole derivatives for the treatment of respiratory syncytial virus infection.
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: April 18, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kuo-Long Yu, Rita Lee Civiello, Mark R. Krystal, Kathleen F. Kadow, Nicholas A. Meanwell
  • O-derivatized nocathiacin derivatives
    Patent number: 7022667
    Abstract: The present invention provides compounds of formula I having potent antibiotic activity, including activity towards Gram-positive bacteria and mycobacteria.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: April 4, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Thomas W. Hudyma, Xiaofan Zheng, B. Narasimhulu Naidu, Margaret E. Sorenson, Alicia Regueiro-Ren, Timothy P. Connolly, John D. Matiskella, Oak K. Kim, Yunhui Zhang, Dane M. Springer, Jason Goodrich, Yasutsugu Ueda, Joanne J. Bronson
  • 3-Thia-4-arylquinolin-2-one derivatives as smooth muscle relaxants
    Patent number: 7002015
    Abstract: This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome.
    Type: Grant
    Filed: October 13, 2004
    Date of Patent: February 21, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventor: Kenneth M. Boy
  • Antiamyloid phenylsulfonamides: N-alkanol derivatives
    Patent number: 6989399
    Abstract: A series of N-alkanol-N-phenyl benzenesulfonamide and related derivatives of the Formula I are disclosed, wherein R1, R2, R3, X, and Y are defined herein. The compounds are inhibitors of ?-amyloid peptide (?-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions characterized by aberrant extracellular deposition of amyloid. Pharmaceutical compositions and methods of treatment are also disclosed.
    Type: Grant
    Filed: July 24, 2003
    Date of Patent: January 24, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: David W. Smith, Michael F. Parker
  • (Oxime)carbamoyl fatty acid amide hydrolase inhibitors
    Patent number: 6949574
    Abstract: The present invention relates to novel oxime carbamyl derivatives and pharmaceutical compositions comprising said derivatives which inhibit fatty acid amide hydrolase. These pharmaceutical compositions are useful for the treatment of conditions which can be effected by inhibiting fatty acid amide hydrolase including, but not limited to, neuropathic pain, emesis, anxiety, altering feeding behaviors, movement disorders, glaucoma, brain injury, and cardiovascular disease.
    Type: Grant
    Filed: February 4, 2003
    Date of Patent: September 27, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Sing-Yuen Sit, Kai Xie, Hongfeng Deng
  • N-cycloalkylglycines as HIV protease inhibitors
    Patent number: 6943170
    Abstract: This invention relates generally to N-cycloalkylglycines of the Formula (I): or a stereoisomeric form, a mixture of stereoisomeric forms, or a pharmaceutically acceptable salt thereof, which are useful as HIV protease inhibitors, pharmaceutical compositions and diagnostic kits including the same, methods for using the same for treating viral infection or an assay standards or reagents, and intermediates and processes for making the same.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: September 13, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventor: David J. Carini
  • Peptide inhibitors of hepatitis C virus NS3 protease
    Patent number: 6939854
    Abstract: This invention relates to a novel class of peptides having the Formula (I): which are useful as serine protease inhibitors, and more particularly as Hepatitis C virus (HCV) NS3 protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same in the treatment of HCV infection.
    Type: Grant
    Filed: January 15, 2004
    Date of Patent: September 6, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventor: E. Scott Priestley