Patents Represented by Attorney, Agent or Law Firm James F. Haley, Jr.
  • Patent number: 6835557
    Abstract: DNA sequences, recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying a biological or immunological activity of human interferon, the genes coding for these polypeptides and methods of making and using these molecules, hosts, genes and polypeptides. The DNA sequences are characterized in that they code for a polypeptide displaying a biological or immunological activity of human interferon. In appropriate hosts these DNA sequences and recombinant DNA molecules permit the production and identification of genes and polypeptides displaying a biological or immunological activity of human interferon and their use in antiviral and antitumor or anticancer agents.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 28, 2004
    Assignee: Biogen, Inc.
    Inventor: Charles Weissmann
  • Patent number: 6827937
    Abstract: This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core antigen particles comprising immunogens, epitopes, or other related structures, crosslinked thereto by ligands which are HBV capsid-binding peptides that selectively bind to HBV core protein. Such particles may be used as delivery systems for a diverse range of immunogenic epitopes, including the HBV capsid-binding peptides, which advantageously also inhibit and interfere with HBV viral assembly by blocking the interaction between HBV core protein and HBV surface proteins. Mixtures of different immunogens and/or capsid-binding peptide ligands may be crosslinked to the same HBV core particle. Such resulting multicomponent or multivalent HBV core particles may be advantageously used in therapeutic and prophylactic vaccines and compositions, as well as in diagnostic compositions and methods using them.
    Type: Grant
    Filed: May 29, 2003
    Date of Patent: December 7, 2004
    Assignee: Biogen Idec MA Inc.
    Inventor: Kenneth Murray
  • Patent number: 6825224
    Abstract: The present invention relates to novel compounds, methods of preparing these compounds, and pharmaceutical compositions comprising these compounds. These compounds are carbamate prodrugs that convert to active inhibitors of the IMPDH enzyme in vivo. The compounds and pharmaceutical compositions of this invention are particularly well suited for activation and subsequent inhibition of the IMPDH enzyme activity. Consequently, these prodrugs may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds and compositions of this invention.
    Type: Grant
    Filed: April 17, 2002
    Date of Patent: November 30, 2004
    Assignee: Vertex Pharmaceuticals, Incorporated
    Inventors: Dean P. Stamos, Randy S. Bethiel
  • Patent number: 6818393
    Abstract: DNA sequences coding for the DR-&bgr;-chain locus of human lymphocyte antigen complex and diagnostic typing processes and products related thereto. DNA sequences that code for the &bgr;-chain DR locus are useful in simple and efficient typing processes and products and for expression of polypeptides displaying an immunological or biological activity of the antigens of the HLA-DR &bgr;-chains for use in diagnostic, preventive and therapeutic agents.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 16, 2004
    Assignee: bioMirieux sa
    Inventors: Bernard Francois Mach, Eric Olivier Long, Claire Terese Wake
  • Patent number: 6818421
    Abstract: The invention relates to DNA sequences coding for proteins having the enzymatic activity of an amylosucrase which allows the synthesis of linear &agr;-1,4 glucans from the substrate sucrose by bacteria, fungi and plants or in cell-free systems. The invention furthermore describes plasmids and bacteria containing these DNA sequences as well as processes for the production of plants and microorganisms capable of intracellularly or extracellularly expressing a polypeptide having amylosucrase activity. The invention furthermore relates to the production of pure fructose using proteins exhibiting the enzymatic activity of amylosucrase.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: November 16, 2004
    Assignee: Bayer BioScience GmbH
    Inventors: Jens Kossmann, Volker Buttcher, Thomas Welsh
  • Patent number: 6815581
    Abstract: Nucleic acid molecules are described encoding a starch granule-bound protein as well as methods and recombinant DNA molecules for the production of transgenic plant cells and plants synthesizing a modified starch with modified viscosity properties and a modified phosphate content. Moreover, the plant cells and plants resulting from those methods as well as the starch obtainable therefrom are described.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: November 9, 2004
    Assignee: PlantTec Biotechnologies, GmbH
    Inventors: Jens Kossmann, Ruth Lorberth
  • Patent number: 6809117
    Abstract: The present invention is based on the discovery that nitric oxide (NO) is an important growth regulator in an intact developing organism. In particular, the present invention relates to a method of increasing in a mammal a population of hematopoietic stem cells in bone marrow which are capable of undergoing normal hematopoiesis and differentiation, wherein the bone marrow is contacted with an inhibitor of NO, such as an inhibitor of nitric oxide synthase (NOS), thereby producing bone marrow having an increased population of hematopoietic stem cells which are capable of undergoing normal hematopoiesis and differentiation. The present invention also relates to a method of increasing a population of cells in S phase in a tissue of a mammal, comprising contacting the tissue with an inhibitor of NO, such as an inhibitor of NOS. The invention also pertains to a method of regenerating tissue in an adult mammal comprising contacting a selected tissue (e.g.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: October 26, 2004
    Assignee: Cold Spring Harbor Laboratory
    Inventors: Grigori N. Enikolopov, Natalia I. Peunova, Boris A. Kuzin, Hollis Cline, Tatiyana Michurina
  • Patent number: 6800626
    Abstract: The present invention relates to inhibitors of p38, a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention relates to compounds having the formula: or pharmaceutically acceptable salts thereof, wherein R, R1, Q1, Q2, X, Y, Z, A, and n are as described in the specification. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: October 5, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Francesco Salituro, Guy Bemis, John Cochran
  • Patent number: 6793933
    Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to enhance the immune system (e.g., increase the activity of T and B lymphocytes and natural killer cells) in a mammal, said ability resulting from their having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making and using these compositions.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: September 21, 2004
    Assignee: Ultra Biotech Limited
    Inventor: Ling Yuk Cheung
  • Patent number: 6790434
    Abstract: The invention relates to cosmetic compositions for topical application for counteracting UV radiation induced skin damage comprising as active substances a first component which comprises inactivated bacteria selected from the group consisting of the genus Bifidobacterium, Actinomycetaceae, Propionimycetaceae, Lactobacillaceae and Coryneform bacteria and a second component which comprises an extract of plant extracellular matrix. Preferably, the plant extracellular matrix is selected from the group consisting of glycoproteins, carbohydrate polymers and arabinogalactan proteins. Processes for using the cosmetic compositions are also described.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: September 14, 2004
    Assignee: Chemisches Laboratorium Dr. Kurt Richter GmbH
    Inventors: Stefan Borchert, Rolf-Dieter Petersen
  • Patent number: 6762346
    Abstract: Nucleic acid molecules are described, which encode debranching enzymes from maize, as well as transgenic plant cells and plants in which an amylopectin with modified properties is synthesized due to the expression of a debranching enzyme from maize or due to the inhibition of such an endogeneous debranching enzyme activity.
    Type: Grant
    Filed: May 8, 2001
    Date of Patent: July 13, 2004
    Assignee: PlantTec Biotechnologie GmbH
    Inventors: Jens Kossmann, Lothar Willmitzer, Michael Emmermann
  • Patent number: 6759055
    Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to improve kidney functions (e.g., restoring urine secretion and/or lowering blood urea nitrogen, serum proteinuria, and/or serum creatinine levels) in a subject as a result of having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making such compositions.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: July 6, 2004
    Assignee: Ultra Biotech Limited
    Inventor: Ling Yuk Cheung
  • Patent number: 6759535
    Abstract: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: July 6, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: John Cochran, Roger Tung
  • Patent number: 6756050
    Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells have been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength for a period of time sufficient to increase the capability of said plurality of yeast cells to improve the memory of a mammal. Also included are methods of making such compositions.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: June 29, 2004
    Assignee: Ultra Biotech Limited
    Inventor: Larry Ling Yuk Cheung
  • Patent number: 6753008
    Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to normalize the serum level of GPT, AP and/or LDH-5 in a mammal, said ability resulting from their having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making and using these compositions.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: June 22, 2004
    Assignee: Ultra Biotech Limited
    Inventor: Ling Yuk Cheung
  • Patent number: 6734339
    Abstract: The present invention relates to nucleic acid molecules encoding enzymes which are involved in the starch synthesis in plants. These enzymes are starch synthases from wheat. The invention further relates to vectors and host cells containing said nucleic acid molecules, in particular transformed plant cells and plants regenerated from these cells, which exhibit an increased or a reduced activity of the described starch synthases.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: May 11, 2004
    Assignee: Hoechst Schering AgrEvo, GmbH
    Inventors: Martina Block, Horst Lörz, Stephanie Lütticke, Lennart Walter, Claus Frohberg, Jens Kossmann
  • Patent number: 6720335
    Abstract: The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: April 13, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Roger D. Tung, Mark A. Murcko, Govinda Rao Bhisetti
  • Patent number: 6716612
    Abstract: The invention describes DNA molecules which code for plant proteins having the biological activity of a debranching enzyme. Furthermore described are transgenic plant cells and plants having reduced or increased debranching enzyme activity, as well as modified starch isolatable from the cells and plants.
    Type: Grant
    Filed: July 29, 2002
    Date of Patent: April 6, 2004
    Inventors: Jens Kossmann, Michael Emmermann, Ivar Virgin, Andreas Renz
  • Patent number: 6716591
    Abstract: Methods and compositions for the prevention, treatment and diagnosis of Lyme disease. Novel B. burgdorferi polypeptides, serotypic variants thereof, fragments thereof and derivatives thereof. Fusion proteins and multimeric proteins comprising same. Multicomponent vaccines comprising novel B. burgdorferi polypeptides in addition to other immunogenic B. burgdorferi polypeptides. DNA sequences, recombinant DNA molecules and transformed host cells useful in the compositions and methods. Antibodies directed against the novel B. burgdorferi polypeptides, and diagnostic kits comprising the polypeptides or antibodies.
    Type: Grant
    Filed: September 14, 1998
    Date of Patent: April 6, 2004
    Assignee: Yale University
    Inventors: Richard A. Flavell, Erol Fikrig, Tuan T. Lam, Fred S. Kantor, Stephen W. Barthold
  • Patent number: 6709849
    Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to treat male hormone deficiency in a subject as a result of having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making such compositions.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: March 23, 2004
    Assignee: Ultra Biotech Limited
    Inventor: Ling Yuk Cheung