Patents Represented by Attorney James G. Passe

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  • Method and compounds for treating inflammatory bowel disease
    Patent number: 4312806
    Abstract: The present invention relates to novel compounds and a method for the prophylaxis and treatment of Inflammatory Bowel Disease (IBD) via the administration of an effective amount in a suitable pharmaceutical dosage form of an azobenzene compound of formula I or a pharmacologically acceptable salt, which is reductively cleaved to 5-aminosalicylic acid (5-ASA) by bacteria in the large intestine.
    Type: Grant
    Filed: March 2, 1981
    Date of Patent: January 26, 1982
    Assignee: G. D. Searle & Co.
    Inventors: Howard J. Lambert, Barnett S. Pitzele
  • .alpha. Chain dienic prostanoic acid derivatives
    Patent number: 4312994
    Abstract: .alpha. Diene 16-hydroxy prostanoic acid derivatives displaying valuable pharmacological properties, e.g., gastric antisecretory, are described herein.
    Type: Grant
    Filed: March 25, 1981
    Date of Patent: January 26, 1982
    Assignee: G. D. Searle & Co.
    Inventor: Paul W. Collins
  • Radiopharmaceutical complexes of N-(tri-substituted alkyl)-iminodiacetic acids
    Patent number: 4308249
    Abstract: Complexes of radiolabelled metals with N-(tri-substituted alkyl)-iminodiacetic acids or salts thereof having utility as radiopharmaceutical agents for monitoring the activity of an organ, their preparation and a method employing such complexes for externally monitoring the activity of an organ are disclosed.
    Type: Grant
    Filed: December 13, 1979
    Date of Patent: December 29, 1981
    Assignee: G. D. Searle & Co.
    Inventors: Patricia Frank, Stephen Kraychy, Ernest F. Le Von
  • Radiopharmaceutical method for monitoring kidneys
    Patent number: 4301140
    Abstract: Complexes of technetium-99m with fructose 6-phosphate or fructose 1,6-diphosphate or salts thereof having utility as radiopharmaceutical agents for monitoring the activity of an organ, their preparation and a method employing such complexes for externally monitoring the activity of an organ are disclosed.
    Type: Grant
    Filed: December 14, 1979
    Date of Patent: November 17, 1981
    Assignee: G. D. Searle & Co.
    Inventors: Patricia Frank, Stephen Kraychy, Ernest F. Le Von
  • {[[4-Azido-5-(ethoxyethyl)-6-phenyl-2-pyrimidinyl]amino]carbonyl}glycine and esters thereof
    Patent number: 4294830
    Abstract: Compounds of the formula ##STR1## wherein R is phenyl or substituted phenyl, R.sub.2 is hydrogen or C.sub.1 -C.sub.4 alkyl and pharmaceutically acceptable salts thereof disclosed. They are useful as antihypertensive agents, substantially devoid of diuretic activity.
    Type: Grant
    Filed: June 16, 1980
    Date of Patent: October 13, 1981
    Assignee: G. D. Searle & Co.
    Inventor: Hans A. Wagner
  • Process for esterification of .alpha.-L-aspartyl-L-phenylalanine
    Patent number: 4293648
    Abstract: A process for selectively esterifying .alpha.-L-aspartyl-L-phenylalanine to the corresponding alkyl esters using a proteolytic enzyme with specific esterase activity is described. The process is carried out in an aqueous-alcohol medium in which the alcohol concentration is sufficient to reverse the esterase activity. The .alpha.-L-aspartyl-L-phenylalanine alkyl esters so produced are useful as artificial sweeteners.
    Type: Grant
    Filed: September 2, 1980
    Date of Patent: October 6, 1981
    Assignee: G. D. Searle & Co.
    Inventor: Arthur A. Davino
  • Electrochemical dehydrogenation of steroidal .DELTA..sup.3,5 enol ethers under basic conditions to provide steroidal .DELTA..sup.4,6 dienones
    Patent number: 4270994
    Abstract: An improved process for the preparation of steroidal .DELTA..sup.4,6 dienones by the electrochemical dehydrogenation of the corresponding .DELTA..sup.3,5 enol ethers under basic conditions, using less than stochiometric amounds of a high potential catalyst, such as 2,3-dichloro-5,6-dicyano-benzoquinone, in a partially aqueous electrolyte solution.
    Type: Grant
    Filed: February 20, 1980
    Date of Patent: June 2, 1981
    Assignee: G. D. Searle & Co.
    Inventor: James R. Behling