Patents Represented by Attorney, Agent or Law Firm James Harrington
-
Patent number: 6825172Abstract: 3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents of the formula: wherein R1, W, R3, R4, R5, R6, X, X′, and Z are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.Type: GrantFiled: May 28, 2003Date of Patent: November 30, 2004Assignee: Janssen Pharmaceutica, NVInventors: Todd C. Henninger, Mark J. Macielag, Brett A. Marinelli, Bin Zhu
-
Patent number: 6432296Abstract: Improved dry-operative ion-selective electrodes and their use are described. The dry-operative ion-selective electrodes include an internal reference electrode comprising a water-soluble salt dispersed in a polymer binder consisting essentially of a monomer having at least one carboxyl group and a hydrophobic monomer. The polymer provides reduced brittleness, good interlayer adhesion and high salt tolerance.Type: GrantFiled: August 30, 2000Date of Patent: August 13, 2002Inventors: Daniel S. Daniel, Richard L. Detwiler, Andrew M. Kirsch, James E. Love, Jr., Richard C. Sutton
-
Patent number: 6322992Abstract: An analytical element can be used to sensitively and rapidly detect a wide variety of specific binding ligands in either a competitive or sandwich assay format. The assays are carried out using a vanadium bromoperoxidase-labeled immunoreactant and a chemiluminescent signal-providing wash composition which comprises a 2,3-dihydro-1,4-phthalazinedione derivative; a halogen, pseudohalogen, halogen-providing source or pseudohalogen-providing source; and a peroxide or a peroxide-generating reagent composition.Type: GrantFiled: October 17, 1997Date of Patent: November 27, 2001Assignee: Johnson & Johnson Clinical Diagnostics, Inc.Inventors: Alan Eric Friedman, Thomas Robert Kissel, Sarah Fingar Groulx, Martha Miller Kopcienski
-
Patent number: 6309661Abstract: Solid, bioabsorbable materials for use as wound dressings comprise at least 50% by weight of a mixture of xanthan and at least one galactomannan, such as guar gum or locust bean gum. The weight ratio of xanthan: total galactomannans is in the range 1:99 to 99:1, preferably 10:99 to 99:10. The material is preferably made in the form of a sponge by freeze drying a mixed aqueous gel of the xanthan and galactomannans.Type: GrantFiled: February 27, 1998Date of Patent: October 30, 2001Inventors: Carla A. Haynes, Elaine Lorimer
-
Patent number: 6046052Abstract: A dry analytical element is disclosed which can be used to sensitively and rapidly detect and quantitate protein. The assays are carried out using a dye that reacts with protein and molybdate ion to produce a measurable change in the spectral absorption of the dye. Also disclosed are polymers which stabilize and enhance the accuracy of the assay, and compounds which reduce interference by bicarbonate.Type: GrantFiled: April 24, 1998Date of Patent: April 4, 2000Assignee: Ortho Clinical Diagnostics, Inc.Inventors: Thomas Arter, David B. LaTart, John C. Mauck, Richard C. Sutton, Wayne Weber, Robert Winterkorn, James Schaeffer
-
Patent number: 5874428Abstract: The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.Type: GrantFiled: March 28, 1996Date of Patent: February 23, 1999Assignee: Novo Nordisk AlsInventors: Florenzio Zaragossa D.o slashed.rwald, Knud Erik Andersen, Rolf Hohlweg, Peter Madsen, Tine Krogh J.o slashed.rgensen, Uffe Bang Olsen, Henrik Sune Andersen, Svend Treppendahl, Polivka Zdenek, Silhankova Alexandra, Sindelar Karel
-
Patent number: 5874558Abstract: A process for expression of a protein product in Aspergillus oryzae is disclosed. The process comprises transforming Aspergillus oryzae with a vector system comprising DNA-sequences encoding functions facilitating gene expression, a suitable marker for selection of transformants, and a DNA-sequence encoding the desired protein product. The process enables industrial production of many different polypeptides and proteins in A. oryzae. Examples of such products are chymosin or prochymosin and other rennets, proteases, lipases and amylases. Also disclosed is an effective promoter for expression of a protein in Aspergillus. A preferred promoter is the TAKA-amylase promoter or functional parts thereof. There is also provided a process for the production of a recombinant Humicola lipase. The recombinant Humicola lipase from A. oryzae differs from the native lipase in having a greater glycosylation and in exhibiting an improved thermostability.Type: GrantFiled: May 17, 1996Date of Patent: February 23, 1999Assignee: Novo NordiskInventors: Esper Boel, Tove Christensen, Helle Fabricius Woldike
-
Patent number: 5830736Abstract: The present invention relates to novel lipolytic enzymes. More specifically the invention provides novel lipolytic enzymes having the properties of a lipase native to the strain Fusarium culmorum CBS 513.94, or has immunochemical properties identical or partially identical to those of a lipase native to the strain Fusarium culmorum CBS 513.94.Type: GrantFiled: April 4, 1997Date of Patent: November 3, 1998Assignee: Novo Nordisk A/SInventors: Karen Margrethe Oxenb.o slashed.ll, Kim Borch, Shamkant Anant Patkar
-
Patent number: 5683361Abstract: A dispenser for dispensing a dosage or a powdery or fluid drug from a cartridge having a tubular chamber the ends of which are sealed by breakable membranes. The dispenser comprises a housing forming a cylinder which is at one end closed by an end wall through which an outlet pipe communicates with the interior of the cylinder. The other end of the cylinder is closed by a plunger which may be displaced into the cylinder. The drug cartridge is placed in a piston mounted axially displaceable in the cylinder between the end wall and the plunger, and the tubular chamber extends from one side of the piston to the other. Penetrators for breaking the membranes are provided at the inner end of the outlet pipe and the inner end of the plunger.Type: GrantFiled: March 31, 1994Date of Patent: November 4, 1997Assignee: Novo Nordisk A/SInventors: Svend Elk, Kim Steengaard, Hans Koster
-
Patent number: 5667990Abstract: The present invention relates to a novel expression system in which A. japonicus-type species are used as host cells for expression of heterologous proteins.Type: GrantFiled: June 1, 1995Date of Patent: September 16, 1997Assignee: Novo Nordisk Biotech, Inc.Inventors: Randy Michael Berka, Wendy Yoder, Shinobu Takagi, Karuppan Chettier Boominathan
-
Patent number: 5667531Abstract: The present invention relates to isolated nucleic acid constructs containing a sequence encoding a polyporus laccase, and the laccase proteins encoded thereby.Type: GrantFiled: June 5, 1995Date of Patent: September 16, 1997Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.Inventors: Debbie Sue Yaver, Feng Xu, Henrik Dalb.o slashed.ge, Palle Schneider, Dorrit A. Aaslyng
-
Patent number: 5665573Abstract: The present invention relates to a method of enzymatic polymerization and/or modification of lignin or lignin containing materials. The invention also relates to the use of this method in the manufacture of wood composites or wood laminates.Type: GrantFiled: December 1, 1994Date of Patent: September 9, 1997Assignee: Novo Nordisk A/SInventor: Birgitte Yde
-
Patent number: 5630525Abstract: A dispenser for consecutive dispensing of tablets in a fixed order comprising a cylindrical body defining along its periphery a number of juxtaposed vertical chutes each accommodating a number of tablets piled on edge radially oriented in the body, a cup shaped dispensing part comprising a bottom plate having an upstanding cylindric wall and forming a stop at the lower end of the chutes. An opening in the cylindric wall allows a tablet on edge to pass from the outside of the cup into the inner space thereof. Above the opening a protrusion extends radially outwards from the cylindric wall into the space between a tablet abreast of the opening and a possible overlying tablet in the chute, and a wall adjacent to the opening extends into the lower ends of the chutes. A detent mechanism makes the body and dispensing part stepwise unidirectionally rotatable in relation to each other.Type: GrantFiled: June 15, 1995Date of Patent: May 20, 1997Assignee: Novo Nordisk A/SInventors: Peter Bender Christoffersen, Ib Hansen
-
Patent number: 5626566Abstract: A pen shaped syringe for repetitive injection of individually set doses of a medicine from a cylinder ampoule reservoir comprises a dose setting member which may be rotated to cause a rotative movement of a dosing member and a combined rotative and axial movement of an indicator member indicating the set dose, and a piston drive member which when rotated in one direction moves the piston into the cylinder ampoule. A unidirectional coupling is established between the dosing member and the piston drive member by each member carrying a disc having surfaces with sector shaped saw teeth riding over each other when the dosing member is rotated in the dose setting direction and engaging each other when the dosing member is rotated in the opposite direction corresponding to the direction of rotation by which the piston is moved into the cylinder ampoule.Type: GrantFiled: March 24, 1994Date of Patent: May 6, 1997Assignee: Novo Nordisk A/SInventors: Lars P. K. Petersen, Niels-Aage B. Hansen
-
Patent number: 5624835Abstract: The molecular characteristics and a partial amino acid sequence of an endo-.beta.-1,4-glucanase obtainable from Aspergillus aculeatus are described, as well as corresponding recombinant DNA sequences, vectors, and transformed hosts. Use of the endo-.beta.-1,4-glucanase or a pectinase preparation enriched with the endo-.beta.-1,4-glucanase for degradation or modification of plant cell walls is described.Type: GrantFiled: October 5, 1994Date of Patent: April 29, 1997Assignee: Novo Nordisk A/SInventors: Kurt Dorreich, Flemming M. Christensen, Yvette Schnell, Marcel Mischler, Henrik Dalb.o slashed.ge, Hans P. Heldt-Hansen
-
Patent number: 5611783Abstract: A pen-shaped syringe comprises a first part containing a dose setting and driving mechanism from which a piston rod is advanced by a carrier to actuate a piston of a reservoir in a second part. The first and second parts are coupled together by a bayonet coupling, wherein the bayonet coupling element of the second part has members for rotating a piston rod guide mounted on the bayonet coupling element of the first part. The piston rod determines the rotational position of the piston rod which rotational position again determines the engagement between the carrier and the piston rod.Type: GrantFiled: May 20, 1994Date of Patent: March 18, 1997Assignee: Novo Nordisk A/SInventor: S.o slashed.ren Mikkelsen
-
Patent number: 5597796Abstract: Insulin analogues have been developed which are well suited for transdermal administration by iontophoresis. The insulin analogues have a negative charge at neutral pH and a reduced tendency to association. They are prepared by altering the human insulin molecule by substituting at least two of the amino acid residues of human insulin by Glu and/or Asp at selected positions in the molecule.Type: GrantFiled: September 7, 1994Date of Patent: January 28, 1997Assignee: Novo Nordisk A/SInventor: Jens J. V. Brange
-
Patent number: 5567869Abstract: A method for quantitation of blood parameters comprises the steps: provision of a sample of plasma, serum or blood, entering the sample into a cuvette with an internal dimension less than 1 mm, illuminating the sample by a light source, measuring and recording the changes of light properties caused by the sample as a function of time, calculating parameters of the recorded light signal/time curve such as slopes, extreme values, and the time distance between such extreme values, and interpreting the parameters as blood parameters. For the measurements, an apparatus is used comprising a cuvette (16, 17) with an internal dimension less than 1 mm, a light source (7, 9), means (8, 10) for measuring currently a light signal from the sample, means for recording the measured light signal values, and means for calculating parameters of the thereby defined light signal versus time graph.Type: GrantFiled: August 3, 1994Date of Patent: October 22, 1996Assignee: Novo Nordisk A/SInventors: Ole Hauch, Jens B. Knudsen, Thomas M. Plum