Abstract: The invention relates to stabilized subtilisin proteases wherein one or more prolines is substituted for a native amino acid at stabilizing positions defined both by the range of the dihedral angles in the primary structure present at the substitution site and by selected characteristics of the protease secondary structure in the vicinity of the substitution site, to nucleotide sequences that encode the stabilized proteases, and to host organisms that contain the nucleotide sequences encoding the stabilized proteases.

Abstract: A plastic top for adapting to a chosen syringe (14) a standard cartridge (8) of the kind having a neck (9) with a flange (10) and being closed by a rubber membrane (11) sealingly secured against the flange (10) by a metal cover (12) having its edge beaded behind the flange. This plastic top has a bore (2) for receiving the neck part (9) of the cartridge (8), which bore (2) has a diameter making it fit over the metal cover (12) and is provided with protrusions (3;9) gripping behind the edge of the metal cover (12) when the neck part (9) is inserted in the bore. The outer contour of the plastic top is adapted to the syringe type in which the cartridge is going to be used.The plastic top is provided with a thread (5;18) coaxial with the bore to receive a needle hub (13) in a way making its needle (15) penetrate the membrane (11) of the cartridge (8) when the hub (13) is mounted on the thread (5) of the plastic top.

Abstract: The present invention relates to a recombinant glucagon like peptide-1 (GLP-1), to a DNA construct which comprises a DNA sequence encoding a GLP-1 receptor, to methods of screening for agonists of GLP-1 activity, and to the use of the GLP-1 receptor for screening for agonists of GLP-1 activity.

Abstract: An insulin injection system comprises a pen shaped syringe with a cartridge containing insulin, and an injection needle. The needle is a G30 needle and the insulin is a type which may freely flow through a G 30 needle. When the insulin is the type comprising suspended crystals the maximal dimension of any crystal is 15 .mu.m.

Abstract: In the method for treatment of potato fruit water the potato fruit water is subjected to a heat treatment to at least 125.degree. C. for at least 3 minutes, whereafter the heat treated potato fruit water is cooled to a temperature, at which enzymes are relatively stable, then enzymatically treated with a proteinase, and finally concentrated to microbial stability. Hereby a method for treatment of potato fruit water, which will enable a commercially sound utilization of potato fruit water, is provided.

Abstract: The present invention is directed to a method for screening samples for the identification of agents exhibiting potential fungicidal and insecticidal activity for a wide variety of agricultural, medical and pharmaceutical uses. The method utilizes cells that comprise a plasmid-born CTS gene of Saccharomyces cerevisiae, which allows for over expression of chitinase.

Abstract: A closure for the outlet end of an ampoule having a neck with an outwardly extending annular projection (30), said closure comprising a holding cap (18;61) with a skirt (35;62) with interior protrusions (38) for engagement behind the annular projection (30) of the neck, which holding cap engages a disc shape part (31) to press it sealingly against the annular projection (30). A locking ring (20;64) on the outer side of the skirt (35;62) locks projections (38) in their engagement position behind the annular projection (30). Resilient fingers (37;65) and recesses (36;66) are provided on either the skirt or the locking ring, the recesses being positioned below the fingers so that the fingers may be pushed into the recesses when the locking ring is passed over the skirt. Either the skirt (35) or the locking ring (64), which part is not provided with the fingers and recesses, is provided with an edge over which the fingers may grip irreversibly when the locking ring is mounted in position on the skirt.

Abstract: A manually operated dispenser for dispensing a predetermined amount of powdered substance comprises a pressure cylinder (2) with an axially displaceable piston (3). A super-atmospheric pressure is generated by displacing the piston inwardly in the cylinder and is releaved through a chamber (41) in a magazine (40) comprising a number of chambers (41) containing powdered substance. The ends of the chambers (41) are covered by penetrable membranes (48), and the chambers (41) may be moved to successively being in alignment with a penetrator (30) and an outlet pipe (46). When the piston (3) is in its inner-most position the penetrator (30) and the inlet end of the out-let pipe (46) are forced through the respective membranes (48) at the ends of the chamber (41), and the subatmospheric pressure is releaved through the chamber (41) to dispense its content through the outlet pipe (46).

Abstract: The present invention relates to a method and apparatus for inspecting entities comprising liquid-filled containers for one or more test parameters of the liquid, the container, or both, by rotating and axially line scanning said entities and comparing said scans electronically, after which entities exhibiting one or more unacceptable test parameters are identified and separated from entities exhibiting acceptable test parameters.

Abstract: A method for measuring the presence of traces of substance in air by providing in a cuvette a substrate reacting with the substance by changing its opacity, passing at a defined flow rate air from the air body to be checked through the substrate, measuring the development of opacity. A portable apparatus comprises a housing (1, 101) holding a cuvette (131) containing a substrate (3, 103), an inlet tube (28) leading to the bottom of the cuvette, a pump (13) sucking air from the cuvette through a flow monitor (138) controlling the pump, a spectrophotometer lamp (19, 119) and a photo-diode (20) on opposite sides of the cuvette (131), a monitor monitoring the level (4, 104) of the substrate in the cuvette, and a monitor (23, 123) monitoring the temperature of the substrate, a computer (24) receiving signals from the photodiode (20), the level monitor, and the temperature monitor to calculate a temperature and level compensated indication of the substrate opacity.

Abstract: A blood sampler comprises a small chamber having a stiletto mounted air-tightly through a flexible top wall with a pointed end of the stiletto positioned inside the chamber opposite an opening in the bottom part of the chamber. The sampler is designed to be mounted in a tool which compresses the chamber by pressing the flexible top wall against the bottom of the chamber. Further, the tool has means for imparting an impact on a blunt outer end of the stiletto to drive the stiletto further through the top wall to make its sharp end protrude through the opening in the bottom part into the skin to which the sampler may be attached by an adhesive. When the sampler is ejected from the tool, it regains its original shape, providing in the chamber a vacuum for sucking blood from the perforated skin into this chamber.

Abstract: The new casein hydrolyzate does not contain any unhydrolyzed casein and is characterized by a defined molecular weight distribution. The method is characterized by being performed by means of three defined proteolytic enzymes and a non-pH star method. The casein hydrolyzate exhibits an optimal balance between DH, free amino acids, bitterness and yield.

Abstract: The present invention relates to the gibbon ape leukemia virus (GALV) receptor protein and gene, as well as methods for regulating viral entry into cells.