Abstract: The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
Type:
Grant
Filed:
June 19, 2002
Date of Patent:
January 16, 2007
Assignee:
Merck Frosst Canada & Co.
Inventors:
Claude Dufresne, Yves Leblanc, Cheuk K. Lau, Patrick Roy, Chun Sing Li