Abstract: Procedures and compositions for forming and stabilizing non stable branch migrated oligo- and polydeoxynucleotides utilizing a displacer which is either single stranded or partially double stranded and hybridized to a linker strand. The displacer may contain one or more modified nucleotides.
Type:
Grant
Filed:
August 31, 1999
Date of Patent:
March 19, 2002
Assignee:
Enzo Therapeutics, Inc.
Inventors:
James G. Wetmur, Robin S. Quartin, Dean L. Engelhardt