Abstract: Improvements in a diagnostic system for determining and/or monitoring a physiological condition in a female mammal are disclosed.

Abstract: Apparatus for analyzing blood or the like has a centrifuge rotor (10) with a means for visibly holding a sample, and a scanning arm (32) which traverses the rotor and includes a means (38) for sending light to the sample to detect the sample component interfaces. A second light source (40) may be provided for colorimetric inspection of the sample.

Abstract: This disclosure related to a method and reagents for determining tetrahydrocannabinoids (THC) and THC metabolites in a biological fluid such as urine. In particular, this disclosure relates to a fluorescence polarization immunoassay procedure for determining the presence of THC and to a novel class of tracer compounds employed as reagents in such procedures. The procedure described also provides for novel wash reagent for a THC fluorescence polarization assay.

Abstract: An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation.

Abstract: Disclosed is a method of producing fusion proteins, particularly HCV fusion proteins, wherein one part of the fusion protein is formed from the bacterial protein CKS.

Abstract: The type of a blood specimen is determined by adding a portion thereof, either a diluted solution of its red cells or a portion of its plasma, to each of a multiplicity of wells in a transparent tray, by adding a blood type specific reagent to each of the wells in the tray, different reagents being added to different ones of the wells of the tray, periodically tilting the tray at a substantial angle of at least approximately 50.degree.

Abstract: Novel pyrene-trisulfonate derivatives and the use thereof in a method for the determination of glycohydrolytic enzyme activity are provided. The method comprises the steps of (a) forming a test solution comprising a test sample containing the glycohydrolytic enzyme and a pyrene-trisulfonate derivative of the present invention, wherein the derivative is hydrolyzed by the glycohydrolytic enzyme to result in the formation of free 8-hydroxy-1,3,6-pyrene trisulfonate as a function of, and which can be correlated to, the amount of the glycohydrolytic enzyme present in the test sample, and (b) measuring and correlating either the intensity of fluorescence, or the optical density, of the test solution to the presence or amount of the glycohydrolytic enzyme in the test sample. A preferred pyrene-trisulfonate derivative is pyrene-1,3,6-trisulfonic acid) 8-.beta. -D-glucuronide for the determination of .beta.-D-glucuronidase for the diagnosis of periodontal disease.

Abstract: This disclosure relates to a method and reagents for determining ligands in biological fluids such as serum, plasma, spinal fluid, amnionic fluid and urine. In particular, this disclosure relates to a fluorescence polarization immunoassay procedure and to a novel class of tracer compounds employed as reagents in such procedures. The procedure disclosed combines the specificity of an immunoassay with the speed and convenience of fluorescence polarization techniques to provide a means for determining the amount of a specific ligand present in a sample.

Abstract: An air/fluid sensing device useful in apparatus for analyzing biological material. The device includes one or more light sources directed at a surface of a container defining an interface with the space enclosed thereby. Depending on whether fluid is present in or absent from the container at the location where said one or more light sources are directed to said surface, the light emanating from the sources will be refracted or reflected, thereby giving an indication of whether fluid is present or absent at said locations.

Abstract: A heating system for heating a rapidly rotating article, including strobe means capable of emitting radiant energy and positioned to radiate energy onto the article, a light source positioned to illuminate a temperature-sensing means on the article, light detector means to measure changes in the light reflected by the temperature-sensing means and control means to energize the strobe means in response to reflected light from the detector means.

Abstract: This disclosure relates to a method and reagents for determining ligands in biological fluids such as serum, plasma, spinal fluid, amnionic fluid and urine. This disclosure also relates to a novel class of tracer compounds employed as reagents in fluorescence polarization immunoassays.

Abstract: An apparatus and method for controlling the operating temperatures and differential temperature of a curie effect temperature sensing switch is disclosed. The temperature switch is adapted to provide temperature control of a cold plate in a reagent refrigerator. The temperature switch activates cold plate cooling devices when the cold plate temperature is above a first operating temperature and deactivates the cold plate cooling devices when the cold plate temperature is below a second operating temperature. An electromagnet is fixed external of and relative to the temperature switch so that the strength of the external magnetic field sets the operating temperatures of the temperature switch. A potentiometer is used to incrementally vary the current supplied to the electromagnet to thereby incrementally adjust the strength of the external magnetic field and the operating temperatures.