Patents Represented by Attorney James Nelson
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Patent number: 5441734Abstract: The present invention provides for crystalline zinc-interferon alfa-2 (IFN .alpha.-2) having a monoclinic morphology. The present invention further provides for crystalline cobalt-IFN .alpha.-2, crystalline calcium-IFN .alpha.-2, and crystalline IFN .alpha.-2 having a serum half-life of at least about 12 hours when injected into a primate. The present invention further provides for a method for producing a crystalline IFN .alpha.-2 comprising forming a soluble metal-IFN .alpha.-2 complex, and equilibrating the soluble metal-IFN .alpha.-2 complex in solution with an acetate salt of the metal under conditions that will cause the metal-IFN .alpha.-2 solution to become supersaturated and form crystalline metal-IFN .alpha.-2. The present invention also includes crystalline metal-alfa interferon having monoclinic, plate and needle morphologies.Type: GrantFiled: February 25, 1993Date of Patent: August 15, 1995Assignee: Schering CorporationInventors: Paul Reichert, Charles McNemar, Nagamani Nagabhushan, Tattanahalli L. Nagabhushan, Stephen Tindall, Alan Hruza
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Patent number: 5188827Abstract: A method for lowering the blood-serum cholesterol levels in mammals by administering IL-4 is disclosed as well as the use of IL-4 for the manufacture of a medicament for use in lowering blood-serum cholesterol levels.Type: GrantFiled: June 10, 1991Date of Patent: February 23, 1993Assignee: Schering CorporationInventor: Hugh E. Black
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Patent number: 5061710Abstract: Novel mercapto-acylamino acids useful in the treatment of hypertension and combinations of mercapto-acylamino acids and atrial natriuretic factors or angiotensin converting enzyme inhibitors useful for treating hypertension are disclosed.Type: GrantFiled: December 16, 1987Date of Patent: October 29, 1991Assignee: Schering CorporationInventors: Martin F. Haslanger, Bernard R. Neustadt, Elizabeth M. Smith
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Patent number: 5035898Abstract: Pharmacuetical compositions for administering a combination of controlled release potassium chloride and immediately-released magnesium salt are disclosed.Type: GrantFiled: November 27, 1987Date of Patent: July 30, 1991Assignee: Schering CorporationInventors: Richard R. Chang, Edward M. Rudnic
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Patent number: 5021457Abstract: Individuals are aided in smoking cessation by administering internally phenylpropanolamine.Type: GrantFiled: August 9, 1989Date of Patent: June 4, 1991Assignee: Plough Inc.Inventors: Frank J. Akin, Robert Klesges, Lisa Klesges
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Patent number: 4863743Abstract: A controlled release potassium chloride tablet is disclosed which is comprised of potassium chloride crystals having a mesh size of about 30 to about 50 mesh which are coated with a coating material comprised of ethylcellulose and hydroxypropylcellulose. The coated crystals form micro pellets which then can be compressed into tablets. The tablets disintegrate rapidly in an aqueous environment thus assuring a more uniform dissolution of the active component as compared with other types of controlled release potassium chloride dosage formulations. The distribution of the potassium chloride micro pellets over a wide surface area in the gastrointestinal mucosa aids in reducing the risk of gastrointestinal lesions. The formation of the coated micro pellets which disperse quickly upon contact with aqueous environment allow for the repeated chronic oral administration of a relatively large dose of potassium chloride (20 mEq).Type: GrantFiled: February 19, 1986Date of Patent: September 5, 1989Assignee: Key Pharmaceuticals, Inc.Inventors: Charles Hsiao, Chi T. Chou
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Patent number: 4351948Abstract: Compounds corresponding to the following general formula: ##STR1## wherein Ar and Ar.sup.1, which may be the same or different, each represents an aromatic radical which may be substituted one or more times by halogen and/or nitro and/or lower alkyl and/or trihalomethyl and/or cyano and/or lower alkoxy and/or di-lower alkyl-amino, the alkyl groups optionally completing a ring optionally incorporating a further heteroatom, and/or lower alkyl sulphonyl;Alk.sup.1 and Alk.sup.2, which may be the same or different, each represents an alkylene group containing from one to eight carbon atoms which may be substituted one or more times by aryl and/or cycloalkyl and/or lower alkyl and if two such alkyl groups are present, they may complete a ring optionally containing a heteroatom and in which imidazole ring may be further substituted; and m represents 0 or 1; provided that not both Ar and Ar.sup.1 represent phenyl; and acid addition salts thereof.Type: GrantFiled: January 16, 1981Date of Patent: September 28, 1982Assignee: G.D. Searle & Co.Inventors: Peter J. Fellner, Brendan J. Hamill, Paul W. Manley
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Patent number: 4349629Abstract: A plasmid having an insertion site for a eukaryotic DNA fragment adjacent to a bacterial promoter and downstream from a prokaryotic ribosome binding site and initiator codon such that the bacterial promoter controls transcription and translation of an inserted DNA fragment is disclosed.The production and use of such plasmids is also disclosed.In general terms, one aspect of the present invention relates to a series of plasmid vectors having the basic characteristic of a Hind III insertion site adjacent to a tryptophan promoter and also a gene for tetracycline resistance. The plasmid vectors are by virtue of the structure thereof ideally suited to receive at the Hind III site an inserted eukaryotic DNA fragment the transcription and translation of which is under the control of the tryptophan promotor.Type: GrantFiled: May 29, 1980Date of Patent: September 14, 1982Assignee: G.D. Searle & Co.Inventors: Norman H. Carey, John S. Emtage, William C. A. Tacon, Robert A. Hallewell
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Patent number: 4348388Abstract: 11-Amino-11-deoxydaunorubicin and analogs represented by the formula: ##STR1## wherein: R is hydrogen, hydroxy or methoxy; R.sub.1 is hydrogen or hydroxy; and the pharmaceutically acceptable salts thereof.The compounds are useful in ameliorating tumor growth.Type: GrantFiled: April 2, 1980Date of Patent: September 7, 1982Assignee: G.D. Searle & Co.Inventors: Robert B. Garland, Raphael Pappo, Paul B. Sollman