Abstract: A casing for firearms, comprising a metal sleeve (15) on which is stably applied, through attachment means, a barrel (12), an inner element (14) made from polymeric material for the anchoring of said sleeve (15) and an outer shell (13) made from polymeric material, is realised through successive overmouldings in sequence of the inner element (14) on the sleeve (15) to form a sleeve—inner element group (11) and then of the shell (13) on the group (11) to form the casing (10).

Abstract: The present invention discloses substituted 1,3-benzodioxoles which possess anti-diabetic and/or anti-hyperglycemic and/or anti-obesity properties in humans and other animals.

Abstract: Oral compositions for the local administration of a therapeutic agent to a periodontal pocket of a patient for alleviating dental disease comprise a plurality of dry, discrete microparticles each of which comprise an effective amount of at least one therapeutic agent dispersed in a matrix comprising a biocompatible and biodegradable polymer. Apparatus and methods are also provided for the dispensing of the dry microparticles to the periodontal pocket whereby they become tacky and adhere to the involved tissue so as to induce long term therapeutic benefits.

Abstract: Pharmaceutical delivery systems containing 7-dimethyl-6-deoxy-6-demethyltetracycline or a non-toxic acid addition salt thereof comprising mixtures or separate administration units of pH sensitive polymer coated spherical granules adapted to release the minocycline in a medium having a pH of in the range of from about 4.0 to about 7.5 and coated or uncoated quick release granules adapted to release minocycline in a medium having a pH of less than about 3.9 or minocycline powder, pH adapted multi-coated compositions and oral dosage unit form liquids, capsules or tablets containing the above are provided. These systems and formulations provide at least minimum therapeutic blood levels of minocycline for at least about 24 hours when administered to a subject only once-a-day. Methods for the preparation of the systems and formulations are provided as well.

Abstract: A controlled release pharmaceutical composition in oral dosage unit form comprising a tablet comprising a therapeutically effective number of active spherical granules comprising an effective amount of active medicament, a pharmaceutically acceptable normally solid diluent adapted to form a diffusable matrix for the active medicament and an optional pharmaceutically acceptable excipient; and a number of compressible spherical granules comprising a mono- or di-saccharide, an optional pharmaceutically acceptable normally solid diluent adapted to form a diffusable matrix, an optional active medicament and/or an optional pharmaceutically acceptable excipient wherein the average compressive yield of the compressible spherical granules is less than the average compressive yield of the active spherical granules is provided. A method for the preparation and for the administration of the above defined composition is provided as well.

Abstract: A topical pharmaceutical formulation, useful as a vehicle for E-type prostaglandins and in the treatment of androgenetic alopecia, is described.

Abstract: A process is disclosed for obtaining the R,R isomer of: ##STR1## wherein R.sub.1 and R.sub.2 may be one or more groups which may be the same or different and are selected from the group consisting of hydrogen, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, hydroxy, halogen, trifluoromethyl, carboxy, hydroxyalkyl, alkoxycarbonyl, C.sub.1 to C.sub.4 thioalkyl, sulfonyl and sulfinyl; X is a divalent radical consisting of ##STR2## wherein R' is hydrogen; R.sub.2 and R.sub.3 may be the same or different and are selected from the group consisting of hydrogen and C.sub.1 to C.sub.4 alkyl; R.sub.5 and R.sub.6 are selected from the group consisting of hydrogen, carboxy, alkoxycarbonyl, hydroxymethyl, --CH.sub.2 OCH.sub.2 COOR.sub.7 and --CH.sub.2 OCH.sub.2 CH.sub.2 OR.sub.7 where R.sub.7 is hydrogen or C.sub.1 to .sub.4 alkyl; except that R.sub.5 and R.sub.

Abstract: Oral compositions for the local administration of a therapeutic agent to a periodontal pocket of a patient for alleviating dental disease comprise a plurality of dry, discrete microparticles each of which comprise an effective amount of at least one therapeutic agent dispersed in a matrix comprising a biocompatible and biodegradable polymer. Apparatus and methods are also provided for the dispensing of the dry microparticles to the periodontal pocket whereby they become tacky and adhere to the involved tissue so as to induce long term therapeutic benefits.

Abstract: The present invention discloses substituted 1,3-benzodioxoles which possess anti-diabetic and/or anti-hyperglycemic and/or anti-obesity properties in humans and other animals.

Abstract: A novel compositions is disclosed which comprises polybutylene terephthalate, polyethylene terephthalate, and 30-85% by total weight of barium sulfate of said molding composition.

Abstract: There is disclosed a process for preparing compositions comprising microcapsules by phase separation microencapsulation wherein the hardening agent employed is a volatile silicone fluid and with the compositions prepared thereby. The use of the volatile silicone fluid as a hardening agent permits the production of microcapsules substantially free of any alkane hardening agent, eliminating potential combustability problems of the prior art processes and toxicity problems of the prior art compositions.

Abstract: A novel molding composition is disclosed which comprises polybutylene terephthalate, polyethylene terephthalate, and 20-85% of zinc oxide by total weight of said molding composition.

Abstract: This application discloses flexible homogenous and smooth compositions whch consists essentially of an interdispersion of low density polyethylene and polychloroprene ingredients and at least an effective amount of fibrous polytetrafluoroethylene interdispersing agent effective to homogeneously blend said ingredients.

Abstract: A method is disclosed for preparing complexes of metals of the VIII Group of the Periodic Table, useful as hydrogenation catalysts. The method, as a single-step process, comprises reacting a polymeric complex containing V Group elements and VIII Group metal compounds directly with a metal atom which is directly bound to the V group element in the presence of a reducing substance. The reducing substance is selected among alkali metal and alkaline earth metal hydrides, mixed alkaline-III group element hydrides, organic metallic compounds of III Group metals, alkali metal and alkaline earth metal alkyls, Grignard compounds.

Abstract: A process is described for preparing triarylmethane derivatives of a high purity in an extremely high yield from 3-phenylphthalide derivatives and aniline derivatives or indole derivatives with Friedel-Crafts type catalyst or Friedel-Crafts type catalyst and an oxidizing agent.

Abstract: A novel process for the preparation of polyphenylene ethers is disclosed that is based on the addition of a polyethoxylated quaternary ammonium salt to the reaction mixture.

Abstract: A ketonic heterocyclic compound having at least two heteroatoms in the ring is prepared by reacting a difunctional compound having the general formula ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are members of the group consisting of aliphatic, aromatic, cycloaliphatic and heterocyclic hydrocarbons which may contain functional groups selected from --OH, --OR.sub.5, --COOH, --COOR.sub.5, --CN, --Cl, --Br, --I, --F, and --CO--R.sub.5, wherein R.sub.5 is an aliphatic, aromatic, cycloaliphatic or heterocyclic hydrocarbon; X is oxygen or sulphur; Y is sulphur or nitrogen; n is an integer ranging from 1 to 3, or zero; R.sub.6 is a hydrogen or a hydrocarbon radical included in the above definition of R.sub.1 R.sub.2 R.sub.3 and R.sub.4 ; and m is the valence of Y, with carbon monoxide and oxygen in the presence of a catalyst selected from selenium, selenium compounds and complexes of copper, in the temperature range of from room temperature to 80.degree.

Abstract: A novel process is disclosed for the removal of catalyst residues from organic solutions of polyphenylene oxides. The process comprises adding a nitrogenous salt of nitrilotriacetic acid to a polyphenylene oxide reaction mixture and thereafter adding an antisolvent for polyphenylene oxide to the mixture to cause the polyphenylene oxide to precipitate.

Abstract: Flame retardant thermoplastic molding compositions are provided comprising a normally flammable linear polyester and a pentavalent phosphorus-containing flame retardant agent. Particularly efficient phosphorus-containing agents are brominated arylphosphates, polyalkylenearyl phosphonates and triarylphosphine oxides.

Abstract: An improved process is provided for preparing polyphenylene ethers by oxidatively coupling a di-ortho substituted phenolic precursor in a reaction system containing oxygen at a pressure of more than one atmosphere, and a complex catalyst formed from a cupric halide and a primary or secondary amine catalyst.