Abstract: Methods are provided for the hybridization of a target polynucleotide with a conjugate. The conjugate comprises an oligonucleotide covalently bound to a linker that is covalently bound to an amino acid or a polyamide. The oligonucleotide portion of the conjugate comprises an anti-sense sequence which is complementary to and hybridizes with the target polynucleotide. The method is useful for detecting the presence of viral or bacterial target polynucleotides.
Type:
Grant
Filed:
October 27, 1997
Date of Patent:
December 8, 1998
Assignee:
Howard Florey Institute of Experimental Physiology and Medicine
Inventors:
Jim Haralambidis, Geoffrey William Tregear
Abstract: Therapeutic compositions and methods for the treatment of inflammation are disclosed. The compositions comprise at least one anti-inflammatory drug in combination with the lymphokine interleukin-4 (IL-4), which components interact synergistically in the treatmement of inflammation. Methods for the treatment of inflammation comprise administering to a subject in need of such treatment an effective amount of at least one anti-inflammatory drug and IL-4.
Type:
Grant
Filed:
September 30, 1994
Date of Patent:
October 6, 1998
Assignee:
University Of Melbourne
Inventors:
John Allan Hamilton, Prudence Hamilton Hart