Patents Represented by Attorney, Agent or Law Firm Jane B. Barrow
  • Shape stabilized erythrocytes
    Patent number: 6436705
    Abstract: One aspect of the present invention is a method for storing tissues and cells (typically erythrocytes) having the step of (1) stabilizing the cells with a reversible stabilizing agent. This method typically will have the additional steps of (2) loading the cells with a cryoprotectant, and typically (3) storing the cells in liquid, frozen, or dry state. This method will also typically have the additional step of (4) prior to use, reversing the stabilization reaction. Preferably, the erythrocytes are pre-treated with CO to complex the hemoglobin with CO. It is anticipated that a practical method according to the invention will include reoxygenation of the eryathrocytes, and also washing out reagents prior to in vivo use. Another aspect of the present invention is an erythrocyte that has had its shape stabilized by the reversible crosslinking of proteins in the erythrocyte, such as the structural proteins of the cytoskeleton.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: August 20, 2002
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Irina B. Bakaltcheva, Alan S. Rudolph, Barry J. Spargo, Samuel B. Leslie, Thomas R. Groel
  • Synthesis of nanostructured composite particles using a polyol process
    Patent number: 6436167
    Abstract: The present invention is a polyol method for making composite particles of two or more immiscible transition metals, where these particles are of nanoscale dimensions, and where the constituent metals are of essentially nanocrystalline morphology. The method of the invention has the steps of (1) dissolving or suspending two or more precursor metal compounds in an alcohol or polyol (diol, triol, etc.) solution, and (2) taking the solution or suspension to a temperature where the metal compound reduces, causing the first and second metals to form nanoscale composites. The term “polyol solution” will be used herein to describe solutions that contain either alcohol or polyol.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: August 20, 2002
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Gan-Moog Chow, Lynn K. Kurihara, Paul E. Schoen
  • Non-exothermic quasi-two level laser
    Patent number: 6370172
    Abstract: A method for selecting laser and pump frequencies for a quasi-two level solid state laser with a selected laser host and operating the laser with the selected laser and pump frequencies, the host having a fluorescence probablility P(&ngr;) over a frequency range from &ngr;i to &ngr;f, has the steps: (a) determining for the laser host, a power weighted average fluorescence frequency <&ngr;F> given by ⟨ v F ⟩ = 1 ( v f - v i ) ⁢ ∫ v i v f ⁢ v ·
    Type: Grant
    Filed: December 27, 1999
    Date of Patent: April 9, 2002
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Steven R. Bowman