Patents Represented by Attorney, Agent or Law Firm Jane E. R. Rotter
  • Pharmaceutical uses and synthesis of diketopiperazines
    Patent number: 6815214
    Abstract: The synthesis of novel diketopiperazines, their use in inhibiting cellular events such as those involving NFK-&agr;, NFK-&bgr; and in the treatment of inflammation events, a combinatorial library of diverse diketopiperazines and process for their synthesis as a library and as individual compounds. In particular novel diketopiperazines are disclosed including their synthesis and use in cellular events such as activation of the transcription factor, nuclear factor, TNF-&agr;, TNF-&bgr; and also apoptosis.
    Type: Grant
    Filed: December 28, 2001
    Date of Patent: November 9, 2004
    Assignee: Celltech R & D, Inc.
    Inventors: Jim P. Boyce, J. Jeffry Howbert, John C. Tabone