Patents Represented by Attorney, Agent or Law Firm Janet B. Smith
  • Method of suppressing tumor cell growth by administering a decorin gene or gene product
    Patent number: 6524573
    Abstract: A method of suppressing tumor growth is provided wherein decorin gene or its gene products are administered so that epidermal growth factor receptor activity is induced. This specific mechanism has been linked to tumor growth suppression.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: February 25, 2003
    Assignee: Thomas Jefferson University
    Inventor: Renato V. Iozzo
  • Radiolabeled vasoactive intestinal peptide analogs for imaging and therapy
    Patent number: 6395255
    Abstract: This invention relates to a radiodiagnostic agent to image tumors. A composition for a tumor imaging agent, a method and kit for preparing a tumor imaging agent, and a radiolabeling reagent for preparing the tumor imaging agent are provided. Methods of using the tumor imaging agent to detect tumors are also provided.
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: May 28, 2002
    Assignee: Thomas Jefferson University
    Inventor: Madhukar (Mathew) L. Thakur
  • Modulation of N-methyl-D-aspartate receptor responses with S-substituted derivatives of glutathione
    Patent number: 6329430
    Abstract: The present invention involves a method of treating pain, neurological diseases and neuronal injury in a mammal by utilizing compounds that interact with and modify one of the redox sites of the N-methyl-D-aspartate (NMDA) receptor in said mammal. These compounds include S-substituted derivatives of glutathione which modulate or regulate the NMDA glutamate receptor.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: December 11, 2001
    Assignee: Thomas Jefferson University
    Inventor: Raymond F. Regan
  • Genetically engineered retroviral vector particles capable of infecting non-dividing cells
    Patent number: 6303116
    Abstract: The present invention is a method of generating retroviral vector particles derived from retroviruses and capable of transducing therapeutic genes into non-dividing cells.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: October 16, 2001
    Assignee: Thomas Jefferson University
    Inventor: Ralph Dornburg
  • Efficient method for production of compound transgenic animals
    Patent number: 6281408
    Abstract: A method of producing compound transgenic animals by co-culturing embryonic stem cells with a morula is provided.
    Type: Grant
    Filed: February 20, 1998
    Date of Patent: August 28, 2001
    Assignee: Thomas Jefferson University
    Inventor: Jaspal S. Khillan
  • Use of magnetic particles in the focal delivery of cells
    Patent number: 6203487
    Abstract: A method for focal delivery of cells to a target tissue in an animal is provided wherein magnetic particles are inserted into cells and then administered into an animal. Focal delivery is accomplished by placement of a magnetic field around or adjacent to the target tissue to which the cells are to be delivered.
    Type: Grant
    Filed: December 31, 1998
    Date of Patent: March 20, 2001
    Assignee: Thomas Jefferson University
    Inventor: P. Macke Consigny