Patents Represented by Attorney Janet T. McClain

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  • Benzamide and sulfonamide hypoglycemic agents
    Patent number: 5397798
    Abstract: The present invention provides novel benzamides and sulfonamides, formulations thereof, and intermediates thereto. The benzamides and sulfonamides of the present invention are useful as hypoglycemic agents and, accordingly, a method of using such compounds to lower a mammal's blood glucose level is also provided.
    Type: Grant
    Filed: July 21, 1992
    Date of Patent: March 14, 1995
    Assignee: Eli Lilly and Company
    Inventors: Lora L. Fitch, Klaus K. Schmiegel
  • Cephalosporin antibacterial agents
    Patent number: 5362722
    Abstract: The present invention provides compounds of the formula ##STR1## wherein R is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, or C.sub.1 -C.sub.6 haloalkyl;A and A' are independently hydrogen, C.sub.1 -C.sub.6 alkyl, nitro, amino, a 5-6 membered organic heterocycle containing 1, 2, or 3 hetero atoms selected from nitrogen or sulfur, C.sub.1 -C.sub.6 alkoxy, or phenyl; or A and A' taken together form a group of the formulae ##STR2## wherein X is hydrogen, halo, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkoxycarbonyl, amino, nitro, or carboxy; and Y is nitrogen or carbon; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions and methods of treatment using the above compounds.
    Type: Grant
    Filed: December 23, 1992
    Date of Patent: November 8, 1994
    Assignee: Eli Lilly and Company
    Inventor: Robert J. Ternansky
  • Process for preparing 7-substituted-amino-3-hydroxy-3-cephem-4-protected carboxy-sulfoxide esters
    Patent number: 5350845
    Abstract: A process for the conversion of a 4-chlorosulfonyl azetidinone (a) to a 3-hydroxy-3-cephem-sulfoxide ester (d) by subjecting an intermediate comprising a tin containing Lewis acid-type Fiedel-Crafts catalyst and 3-exomethylene cepham to ozonolysis.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: September 27, 1994
    Assignee: Eli Lilly and Company
    Inventor: Frank Brown, Jr.
  • A82846 antibiotics
    Patent number: 5312738
    Abstract: New glycopeptide antibiotic A82846, comprising A82846A, A82846B and A82846C, is produced by Nocardia orientalis strains NRRL 18098, NRRL 18099 and NRRL 18100. The A82846 antibiotics have activity against Gram-positive bacteria comparable to that of vancomycin.
    Type: Grant
    Filed: May 9, 1990
    Date of Patent: May 17, 1994
    Assignee: Eli Lilly and Company
    Inventors: Robert L. Hamill, James A. Mabe, David F. Mahoney, Walter M. Nakatsukasa, Raymond C. Yao
  • Ester cleavage process for use with .beta.-lactams
    Patent number: 5302711
    Abstract: The present invention provides a novel ester cleavage process for use with .beta.-lactams. The process is useful because of mild conditions necessary to complete the reaction, such conditions being especially suitable for .beta.-lactams.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: April 12, 1994
    Assignee: Eli Lilly and Company
    Inventors: Jack W. Fisher, Kristina Thomas