Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria.
Type:
Grant
Filed:
April 6, 1995
Date of Patent:
April 18, 2000
Assignee:
SmithKline Beecham p.l.c.
Inventors:
Martin Cole, Thomas Trevor Howarth, Christopher Reading