Abstract: Antibodies which target clusterin, a protein involved in the epithelial-to-mesenchymal transition of carcinoma cells, are identified and characterized. The antibodies may be used to modulate tumour cell activity through binding to clusterin.
Type:
Grant
Filed:
September 13, 2006
Date of Patent:
October 25, 2011
Inventors:
Maureen D. O'Connor-McCourt, Christiane Cantin, Anne E. G. Lenferink