Patents Represented by Attorney Jason D. Ferrone
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Patent number: 6841664Abstract: Novel 6,11-4-carbon bridged ketolides, pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically-acceptable carrier are described. Also described are a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically effective amount of a compound of the invention and processes for the preparation of such compounds.Type: GrantFiled: July 25, 2002Date of Patent: January 11, 2005Assignee: Enanra Pharmaceuticals, Inc.Inventors: Yat Sun Or, Guoqiang Wang, Deqiang Niu, Ly Tam Phan
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Patent number: 6812216Abstract: There are described 11-C-substituted derivatives of clarithromycin and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.Type: GrantFiled: June 25, 2002Date of Patent: November 2, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Ly Tam Phan, Jay Judson Farmer, Yat Sun Or
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Patent number: 6809077Abstract: The present invention relates to a cyclosporin analog of the following formula (I) or a pro-drug or pharmaceutically acceptable salt thereof: In particular, residue A maybe represented by either formula A1 or A2 as illustrated below: where X and Y are defined herein. In a second embodiment, the present invention relates to pharmaceutical compositions comprising pro-drugs or pharmaceutically acceptable salts of the compounds of the present invention and the use thereof for treating autoimmune diseases or for the prevention of organ transplantation rejection in a subject. In a third embodiment, the present invention relates to processes for the production of novel cyclosporin analogs of the present invention.Type: GrantFiled: October 12, 2001Date of Patent: October 26, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Yat Sun Or, Tsvetelina Ivanova Lazarova, Blake Christopher Hamann, Jason Shih-Hao Chen
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Patent number: 6790835Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.Type: GrantFiled: June 5, 2003Date of Patent: September 14, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Yao-Ling Qiu, Ly Tam Phan, Tongzhu Liu, Zhigang Chen, Yat Sun Or
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Patent number: 6784156Abstract: The present invention relates to novel semisynthetic cyclosporin analogs of Formula (I): X is absent, —C1-C6 alkyl-, or —C3-C6 cycloalkyl- Y is selected from the group consisting of: (i) C(O)—O—R1, where R1 is hydrogen, C1-C6 alkyl, optionally substituted with halogen, heterocyclic, aryl, C1-C6 alkoxy, C1-C6 alkylthio, halogen-substituted C1-C6 alkoxy, or halogen-substituted C1-C6 alkylthio; (ii) C(O)—S—R1, where R1 is as previously defined; (iii) C(O)—OCH2—OC(O)R2, where R2 is C1-C6 alkyl, optionally substituted with halogen, C1-C6 alkoxy; C1-C6 alkylthio, heterocyclic or aryl; (iv) C(S)—O—R1, where R1 is as previously defined, and (v) C(S)—S—R1, where R1 is as previously defined; B is -&agr;Abu-, -Val-, -Thr- or -Nva-; and U is -(D)Ala-, -(D)Ser-, —[O-(2-hydroxyethyl)(D)Ser]-, —[O-acyl(D)Ser]- or —[O-(2-acyloxyethyl)(D)Ser]-.Type: GrantFiled: March 5, 2001Date of Patent: August 31, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Yat Sun Or, Tsvetelina Lazarova
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Patent number: 6774115Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.Type: GrantFiled: June 5, 2003Date of Patent: August 10, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Yao-Ling Qiu, Ly Tam Phan, Yat Sun Or
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Patent number: 6764998Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.Type: GrantFiled: June 18, 2003Date of Patent: July 20, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Guoqiang Wang, Yat Sun Or, Ly Tam Phan
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Patent number: 6765016Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.Type: GrantFiled: June 5, 2003Date of Patent: July 20, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Yao-Ling Qiu, Ly Tam Phan, Zhigang Chen, Tongzhu Liu, Yat Sun Or
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Patent number: 6753415Abstract: There are described novel 5-O-mycaminosyltylonide (OMT) analogs possessing increased antibacterial activity toward Gram positive and Gram negative bacteria as well as macrolide resistant Gram positives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier.Type: GrantFiled: April 19, 2002Date of Patent: June 22, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Ly Tam Phan, Yao-Ling Qiu, Yat Sun Or, Nha Vo, Tianying Jian, Ying Hou, Marina Busuyek
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Patent number: 6753318Abstract: Novel 6,11-4-carbon bridged erythromycin derivatives and pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically-acceptable carrier are described. Also described are methods for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically effective amount of a compound of the invention and processes for the preparation of such compounds.Type: GrantFiled: July 25, 2002Date of Patent: June 22, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Yat Sun Or, Guoqiang Wang, Deqiang Niu, Ly Tam Phan
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Patent number: 6750204Abstract: There are described 11-C-substituted derivatives of erythromycin and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.Type: GrantFiled: June 25, 2002Date of Patent: June 15, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Ly Tam Phan, Jay Judson Farmer, Yat Sun Or
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Patent number: 6727229Abstract: Novel 11-12 substituted lactone ketolide derivatives and pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically-acceptable carrier are described. Also described are a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically effective amount of a compound of the invention and processes for the preparation of such compounds.Type: GrantFiled: August 19, 2002Date of Patent: April 27, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Nha Huu Vo, Ly Tam Phan, Ying Hou, Tongzhu Liu, Yat Sun Or
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Patent number: 6720308Abstract: Novel 11-12 substituted lactone anhydrolide derivatives and pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically-acceptable carrier are described. Also described are a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically effective amount of a compound of the invention and processes for the preparation of such compounds.Type: GrantFiled: November 7, 2002Date of Patent: April 13, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Nha Huu Vo, Ying Hou, Ly Tam Phan, Yat Sun Or
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Patent number: 6696494Abstract: Acylated &agr;-hydroxyarylbutanamines and related sulfonamides, ureas and carbamates that inhibit aspartyl protease are disclosed, as are methods of treating diseases, particularly HIV, using these compounds.Type: GrantFiled: October 22, 2001Date of Patent: February 24, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Yat Sun Or, Guoqiang Wang, John Rougas, Jude Elizabeth Mathews, Kate Ryan Muldoon, Vincent Alfred Boyd, Jens Werner Eckstein, Steven Wayne Riesinger
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Patent number: 6680299Abstract: There are described novel 4′ substituted 16-membered macrolides and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.Type: GrantFiled: July 27, 2001Date of Patent: January 20, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Yat Sun Or, Ly Tam Phan, Zhaolin Wang, Tianying Jian
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Patent number: 6673774Abstract: There are described 11-O-substituted macrolides and their descladinose derivatives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.Type: GrantFiled: December 3, 2001Date of Patent: January 6, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Ly Tam Phan Phan, Deqiang Niu, Yat Sun Or
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Patent number: 6673821Abstract: Nitrogen heterocycles that inhibit aspartyl protease are disclosed, as are methods of treating diseases, particularly HIV, using these compounds.Type: GrantFiled: October 22, 2001Date of Patent: January 6, 2004Assignee: Enanta Pharmaceuticals, Inc.Inventors: Guoqiang Wang, Yat Sun Or, John Rougas, Steven Wayne Riesinger
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Patent number: 6670331Abstract: There are described novel 11-O-substituted ketolide derivatives of clarithromycin analogs and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.Type: GrantFiled: December 4, 2001Date of Patent: December 30, 2003Assignee: Enanta Pharmaceuticals, Inc.Inventors: Ly Tam Phan Phan, Deqiang Niu, Yat Sun Or
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Patent number: 6645941Abstract: The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.Type: GrantFiled: March 26, 2003Date of Patent: November 11, 2003Assignee: Enanta Pharmaceuticals, Inc.Inventors: Guoqiang Wang, Yat Sun Or, Ly Tam Phan, Marina Busuyek