Patents Represented by Attorney Jay R. Akhave

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  • Process for preparation of rosuvastatin calcium field of the invention
    Patent number: 8212035
    Abstract: The present invention relates to an improved process for preparing (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium of Formula (I).
    Type: Grant
    Filed: February 4, 2008
    Date of Patent: July 3, 2012
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Ramesh Dandala, Sambhu Prasad Sarma Mallela, Sukumar Nandi, Gangadhar Bhima Shankar Nandi, Sunil Kumar Buridipadu, Sivakumaran Meenakshisunderam
  • Process for preparing rosuvastatin calcium
    Patent number: 8212034
    Abstract: The present invention relates to an improved process for preparing (2E)-3-[4-(4-fluorophenyl)-6-iso-propyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-propenal of Formula I which is an intermediate useful in the preparation of bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoicacid]calcium salt of Formula II.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: July 3, 2012
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Ramesh Dandala, Sambhu Prasad Sarma Mallela, Sukumar Nandi, Gangadhar Bhima Shankar Nangi, Sunil Kumar Buridipadu, Sivakumaran Meenakshisunderam
  • Process for preparing nevirapine
    Patent number: 8212025
    Abstract: An improved process for preparing 11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2?,3?-e][1,4]diazepin-6-one of Formula (I).
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: July 3, 2012
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Jagan Mohan Reddy Sanapureddy, Ramesh Dandala, Sivakumaran Meenakshisunderam
  • Process for preparing olanzapine form I
    Patent number: 8106188
    Abstract: An improved for preparing Olanzapine Form I of Formula 1 in the presence of one solvent or a mixture of solvents.
    Type: Grant
    Filed: June 1, 2006
    Date of Patent: January 31, 2012
    Assignee: Aurobindo Pharma Ltd
    Inventors: Uttam Kumar Ray, Sreenivasa Rao Pathuri, Sivakumaran Meenakshisunderam
  • Process for the preparation of Escitalopram
    Patent number: 7939680
    Abstract: The present invention relates to an improved process for the preparation of Escitalopram of the Formula (I), which comprises, isolation of Diol compound as an oxalate salt, resolution of Diol compound and cyclization of resolved compound of Formula (VII). The present invention provides a process to obtain pure Diol compound by preparing its Oxalate salt, which is useful for resolution of enantiomers.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: May 10, 2011
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Vipin Kumar Kaushik, Umar Khan Mohammed, Sivakumaran Meenakshisunderam
  • Process for the preparation of biphosphonic acids
    Patent number: 7528280
    Abstract: An improved process for bisphosphonylation of acids, substituted acids to obtain compounds with the formula using phosphorus trihalide, phosphorus acid, in presence of phenolic compounds as diluent/solvent.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: May 5, 2009
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Subba Reddy Danda, Narayan K. A. S. S. Garimella, Srinivasa Rao V. N Divvela, Ramesh Dandala, Sivakumaran Meenakshisunderam
  • Process for the preparation of pure Finasteride
    Patent number: 7164022
    Abstract: The present invention relates to an improved process for the preparation of pure Finasteride of Formula I, which comprises converting dihydrofinasteride to finasteride through novel protected dihydrofinasteride and protected finasteride intermediates.
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: January 16, 2007
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Ramesh Dandala, Divvela Venkata Naga Srinvasa Rao, Koilpillai Joseph Prabahar, Gollapalli Venkateswara Rao, Meenakshisunderam Sivakumaran
  • Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate
    Patent number: 7041826
    Abstract: The present invention describes an industrially advantageous process to prepare highly pure 1-Methyl-3-phenylpiperazine of Formula I that makes use of a novel piperazine derivative, 4-Benzyl-1-methyl-2-oxo-3-phenylpiperazine, represented by Formula II 1-Methyl-3-phenylpiperazine is a useful intermediate in the preparation of antidepressant Mirtazapine.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: May 9, 2006
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Vijay Kumar Handa, Divvela Venkata Naga Srinivasa Rao, Meenakshisunderam Sivakumaran
  • Process for the preparation of a highly pure pharmaceutical intermediate, 4-(cyclopropylcarbonyl)-?, ?-dimethylphenylacetic acid
    Patent number: 6903232
    Abstract: This invention relates to a novel process to obtain highly pure 4-(cyclopropylcarbonyl)-?,?-dimethylphenylacetic acid of Formula I through crystallization from a mixture of para and meta regioisomers of Formula I and II in cyclohexane, whereby the amount of undesired meta isomer, 3-(cyclopropylcarbonyl)-?,?-dimethylphenylacetic acid of Formula II is decreased to below 0.5%. The compound of Formula I is a key intermediate for the preparation of high purity terfenadine carboxylate, which is a known antihistaminic.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: June 7, 2005
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Ramesh Dandala, Umashankar Das, Divvela Venkata Naga Srinivasa Rao, Meenakshisunderam Sivakumaran
  • Process for lactonization to produce highly pure simvastatin
    Patent number: 6825362
    Abstract: There is disclosed, a process for lactonization to produce highly pure simvastatin of Formula I which comprises lactonization of a compound of Formula II where Z is H or NH4 in a mixture of acetonitrile and glacial acetic acid under anhydrous conditions at a temperature of 65-70° C.
    Type: Grant
    Filed: June 23, 2003
    Date of Patent: November 30, 2004
    Assignee: Aurobindo Pharma Limited
    Inventors: Ramesh Dandala, Sonny Sebastian, Dandala Subramanyam, Meenakshisunderam Sivakumaran
  • Process for lactonization to produce simvastatin
    Patent number: 6797831
    Abstract: There is disclosed a process for the manufacture of simvastatin of Formula I which comprises heating a compound, namely acid or ammonium salt of compound of Formula II, where Z is H or NH4 in an organic solvent at a temperature of 130-140° C.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: September 28, 2004
    Assignee: Aurobindo Pharma Limited
    Inventors: Ramesh Dandala, Sonny Sebastian, Sanapureddy Jagan Mohan Reddy, Meenakshisunderam Sivakumaran