Patents Represented by Attorney, Agent or Law Firm Jay Z. Zhang
  • Membrane-associated protein 17KD (MAP17)-interacting protein and use thereof
    Patent number: 6831154
    Abstract: Protein complexes are provided comprising MAP17 and SCAMP2. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes and in treating and/or preventing diseases and disorders associated with MAP17 and SCAMP2. In addition, methods for detecting the protein complexes and modulating the functions and activities of the protein complexes or interacting members thereof are also provided.
    Type: Grant
    Filed: May 14, 2002
    Date of Patent: December 14, 2004
    Assignee: Myriad Genetics, Inc.
    Inventor: Paul Bartel
  • Method of detecting protein-protein interactions
    Patent number: 6828112
    Abstract: A method for detecting protein-protein interactions is provided, in which two fusion proteins are prepared and allowed to interact with each other. The interaction between the two fusion proteins leads to protein trans-splicing, generating an active and detectable reporter.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: December 7, 2004
    Assignee: Myriad Genetics, Inc.
    Inventors: John Manfredi, Jay Zhang
  • VAMP-associated protein A-interacting proteins and use thereof
    Patent number: 6828421
    Abstract: Protein complexes are provided comprising VAP-A and one or more VAP-A-interacting proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes and in treating and/or preventing diseases and disorders associated with VAP-A and its interacting partners. In addition, methods of detecting the protein complexes and modulating the functions and activities of the protein complexes or interacting members thereof are also provided.
    Type: Grant
    Filed: May 14, 2002
    Date of Patent: December 7, 2004
    Assignee: Myriad Genetics, Inc.
    Inventor: Janice Sugiyama
  • Yeast two-hybrid system and use thereof
    Patent number: 6562576
    Abstract: A method for detecting protein-protein interactions is provided, in which two fusion proteins are prepared and allowed to interact with each other in yeast cells. The interaction between the two fusion proteins leads to protein trans-splicing, generating an active and detectable reporter.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: May 13, 2003
    Assignee: Myriad Genetics, Inc.
    Inventor: John Manfredi
  • Screen assay for selecting protein-protein interaction modulators
    Patent number: 6551786
    Abstract: A method for selecting compounds capable of modulating protein-protein interactions is provided, in which two fusion proteins are prepared and allowed to interact with each other in the presence of test compounds. The interaction between the two fusion proteins leads to protein trans-splicing, producing an active reporter. Compounds that disrupt or enhance protein-protein interactions can be selected based on the presence or absence of the active reporter.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: April 22, 2003
    Assignee: Myriad Genetics, Inc.
    Inventor: John Manfredi