Abstract: Nucleic acids encoding various lymphocyte cell proteins from mammalian, including primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
Type:
Grant
Filed:
July 8, 1998
Date of Patent:
August 21, 2001
Assignee:
Schering Corporation
Inventors:
Jenny Valladeau, Odile Ravel, Elizabeth Esther Mary Bates, John Ford, Sem Saeland, Serge J. E. Lebecque
Abstract: The present invention provides human ras converting endoprotease (RCE), the encoding nucleic acids, recombinant vectors, transformed host cells and methods of making human RCE. More particularly, the invention provides methods of using human RCE in screening systems to identify inhibitors of human RCE useful for the treatment of various medical conditions. This invention further relates to inhibitors of human RCE.
Type:
Grant
Filed:
March 4, 1999
Date of Patent:
July 17, 2001
Assignee:
Schering Corporation
Inventors:
David Whyte, Marnie McGuirk, Irma Nuñez-Oliva, Tish Hockenberry, James Pai
Abstract: A method for enhancing the immune response of a mammal to a vaccine comprising administering to such a mammal an effective amount of IL-10 in conjunction with the vaccine. A pharmaceutical composition comprised of an effective amount of IL-10, a natural, synthetic or recombinant antigen and a pharmaceutcally acceptable carrier.