Patents Represented by Attorney, Agent or Law Firm Jeanne M. DiGiorgio
  • Hybrid compositions for intracellular targeting
    Patent number: 6482586
    Abstract: Hybrid compounds comprising a first domain and a second domain are provided. The first domain and the second domain are preferably covalently linked, and the first domain comprises a domain which is capable of specific binding to Gb3; and the second domain comprising a moiety selected from the group consisting of drug moiety, a nucleic acid, a probe, a polypeptide, and a hook, with the proviso that the second domain is not a verotoxin or a fragment thereof. Mehtods of preapring and using the hybrid compounds are also provided.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: November 19, 2002
    Assignee: Hospital for Sick Children Research and Development Limited Partnership
    Inventors: Sara Arab, Clifford A. Lingwood, Aye-Aye Khine
  • Verotoxin pharmaceutical compositions and medical treatments therewith
    Patent number: 6228370
    Abstract: Pharmaceutical compositions comprising known verotoxins, particularly, verotoxin 1, have been found to be useful in the treatment of mammalian neoplasia, particularly, ovarian cancer and skin cancer. Surprisingly, although verotoxin 1 has previously been shown to have anti-neoplastic activity in vitro, non-lethal doses of verotoxin 1 have been shown to be therapeutically anti-neoplastic in vivo.
    Type: Grant
    Filed: July 29, 1997
    Date of Patent: May 8, 2001
    Inventors: Clifford A. Lingwood, Hannah Farkas-Himsley, Richard Hill