Abstract: Methods for detecting influenza virus A and influenza virus B nucleic acids in biological samples by using in vitro amplification and detection are disclosed. Compositions that are target-specific nucleic acid sequences and kits comprising target-specific nucleic acid oligomers for amplifying in vitro influenza virus A or influenza virus B nucleic acid and detecting amplified nucleic acid sequences are disclosed.
Type:
Grant
Filed:
May 28, 2010
Date of Patent:
December 25, 2012
Assignee:
Gen-Probe Incorporated
Inventors:
Elizabeth M. Marlowe, Paul M. Darby, Damon K. Getman, Sylvia A. Norman, Reinhold B. Pollner
Abstract: Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products are disclosed.
Type:
Grant
Filed:
August 23, 2011
Date of Patent:
December 18, 2012
Assignee:
Gen-Probe Incorporated
Inventors:
Sylvia A. Norman, Jennifer J. Bungo, William L. Hanna, Neeraj P. Rao
Abstract: Methods for efficiently capturing a target nucleic acid from a sample by using a mixture that contains a capture probe specific for the target nucleic acid, the target nucleic acid, and a denaturant chemical, which mixture is incubated at elevated temperature for a short time, are disclosed. Compositions that include a capture probe that specifically binds to a target nucleic acid and a denaturant chemical, which when mixed with the target nucleic acid and incubated at elevated temperature for a short time, promote efficient hybridization of the capture probe and target nucleic acid are disclosed.
Type:
Grant
Filed:
May 5, 2006
Date of Patent:
August 9, 2011
Assignee:
Gen-Probe Incorporated
Inventors:
Reinhold B. Pollner, Michael M. Becker, Mehrdad R. Majlessi
Abstract: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zyctor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zyctor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
Type:
Grant
Filed:
October 20, 2006
Date of Patent:
May 24, 2011
Assignee:
ZymoGenetics, Inc.
Inventors:
Cindy A. Sprecher, Scott R. Presnell, Zeren Gao, Theodore E. Whitmore, Joseph L. Kuijper, Mark F. Maurer