Patents Represented by Attorney, Agent or Law Firm Jeffrey I. Auerbach
-
Patent number: 7063918Abstract: The present invention relates to a unique polymeric battery system of electrochemical cells that are connected in series, and can be of nanometer size. The polymers possess conjugated bonds along their backbones and high levels of metals. The invention also concerns methods for the fabrication of the polymers and battery system as well as methods for the use of the polymers as a nanoscale solid-state battery.Type: GrantFiled: October 22, 2001Date of Patent: June 20, 2006Assignee: The University of Maryland, College ParkInventors: Peter Kofinas, Steven Bullock
-
Patent number: 7049560Abstract: A tape heater includes an electric heating wire disposed on a surface of a heat-resistant, flexible substrate strip. The electric heating wire and the substrate strip are wrapped with a heat-resistant resin wrap.Type: GrantFiled: March 31, 2004Date of Patent: May 23, 2006Assignee: Nichias CorporationInventors: Keiichi Fukuda, Yoshiyuki Motoyoshi
-
Patent number: 7010751Abstract: The present invention provides software for electronically annotating electronic images, such as drawings, photographs, video, etc., through the drag-and-drop of annotations from a pre-defined, but extendable, list. The annotations are placed at a user-selected X, Y location on the image, and stored in a searchable database. Thus, they can be searched in order to retrieve, organize, group, or display desired electronic images or collections of such images. The annotations may be text, images, sounds, etc. The invention provides a flexible, easy to learn, rapid, low error rate and satisfying interface for accomplishing such tasks.Type: GrantFiled: October 15, 2001Date of Patent: March 7, 2006Assignee: University of Maryland, College ParkInventor: Ben A. Shneiderman
-
Patent number: 6815394Abstract: A phenyl ester is produced by allowing benzene, a carboxylic acid and molecular oxygen to react with each other in the presence of a catalyst comprising (A) palladium, (B) at least one element selected from elements of groups 13, 14, 15, and 16 and the fourth to sixth periods of the periodic table, and (C) at least one element selected from elements of groups 3, 4 and lanthanoid elements of the periodic table. Preferably, element (B) is selected from elements of group 16 and the fourth to sixth periods of the periodic table, and element (C) is contained in a metal oxide form in the catalyst.Type: GrantFiled: November 13, 2002Date of Patent: November 9, 2004Assignee: Tosoh CorporationInventors: Yoshihiko Mori, Takao Doi, Tetsuo Asakawa, Takanori Miyake
-
Patent number: 6780413Abstract: Compositions and methods for treatment of focal muscle spasms. Immunotoxin conjugates comprise a toxin conjugated to an antibody reactive to a muscle specific antigen.Type: GrantFiled: November 7, 2001Date of Patent: August 24, 2004Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Jonathan S. Hott, Richard J. Youle, Mark Hallett, Marinos C. Dalakas
-
Patent number: 6706528Abstract: The present invention generally relates to analytical elements and methods for the selective determination of magnesium. In particular, the present invention is further directed to carboxy-quinolizine suitable for use as magnesium indicators, and more particularly, to 4-oxo-4H-quinolizine-3-carboxylic acid derivatives for use as novel fluorescent magnesium indicators.Type: GrantFiled: March 23, 2001Date of Patent: March 16, 2004Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Robert E. London, Pieter Otten, Louis A. Levy
-
Patent number: 6673347Abstract: Protein and polypeptide derivatives and their salts are claimed characterized in that a protein or polypeptide is conjugated via an intermediate grouping containing at least one radical of the formula —C(R)═N— (or —N═C(R)—) or —CH(R)—NH— (or —NH—CH(R)—), wherein R is hydrogen or a hydrocarbon residue which may be substituted, with the same or a different protein or polypeptide, with a reporter group or a cytotoxic agent as well as a process for their preparation and the novel intermediates therefor.Type: GrantFiled: May 12, 1994Date of Patent: January 6, 2004Assignee: Gryphon TherapeuticsInventors: Robin Ewart Offord, Keith Rose
-
Patent number: 6663869Abstract: A homogeneous polyoxime composition is provided, in which the polyoxime molecules present comprise a first organic baseplate molecule, which is a polypeptide, wherein the baseplate molecule is linked to at least two second organic molecules, which may be the same or different from one another. In the compositions, the linkages between the baseplate and said organic molecules are oxime linkages formed by reaction of an orthogonal reactive group on each the organic molecules with a complementary orthogonal reactive group on the baseplate.Type: GrantFiled: August 4, 2000Date of Patent: December 16, 2003Assignee: Gryphon Therapeutics, Inc.Inventors: Keith Rose, Robin E. Offord
-
Patent number: 6599644Abstract: A method of producing an ohmic contact to p-type silicon carbide comprising two layers, the first one comprising nickel silicide and the second one comprising titanium carbide is disclosed. The deposited layers are annealed to convert at least a part of deposited metals to nickel silicide and titanium carbide. The contact is formed by reaction between the metals and the semiconductor, and thus the in-situ simultaneous formation of metal silicide and carbide suppress the release of excess carbon at the contact interface. Noble metals may be deposited preferably in between titanium and nickel to improve the contact morphology.Type: GrantFiled: October 4, 2001Date of Patent: July 29, 2003Assignee: Foundation for Research & Technology-HellasInventors: Konstantinos Zekentes, Konstantin V. Vassilievski
-
Patent number: 6562955Abstract: An oligonucleotide for detection or amplification of a gene selected from the group consisting of Vibrio parahaemolyticus thermostable direct hemolysin-related hemolysin genes (trh1 and trh2) and Vibrio parahaemolyticus thermostable direct hemolysin gene (tdh2) or RNA derived therefrom is provided. Further, method for detecting trh1, trh2 or tdh2 using said oligonucleotide is provided.Type: GrantFiled: March 15, 2001Date of Patent: May 13, 2003Assignee: Tosoh CorporationInventors: Tetsuya Ishizuka, Takahiko Ishiguro, Juichi Saitoh
-
Patent number: 6552167Abstract: Provided are chains of precise length and methods for their preparation. These chains are formed by the reaction of a derivative of a diacid and a diamine in a stepwise manner on a support. One of the reactants contains a water soluble oligomer, preferably polyethylene glycol. These chains are then used to chemically modify target macromolecules such as biologically important polypeptides.Type: GrantFiled: August 23, 1999Date of Patent: April 22, 2003Assignee: Gryphon Therapeutics, Inc.Inventor: Keith Rose
-
Patent number: 6541205Abstract: A method for assaying a target nucleic acid, comprising: providing an RNA amplification system comprising producing a double-stranded DNA using, as a template, a target RNA containing a specific nucleotide sequence in a sample, said double-stranded DNA having a promoter sequence and being capable of transcribing an RNA comprising the specific nucleotide sequence or a sequence complementary to the specific nucleotide sequence, producing an RNA transcription product comprising the specific nucleotide sequence or a sequence complementary to the specific nucleotide sequence in the presence of an RNA polymerase, and producing the double-stranded DNA using the RNA transcription product as a template, in the presence of a probe labeled with an intercalating fluorochrome having a sequence complementary to the RNA transcription product; measuring the fluorescence intensity in the RNA amplification system with time; calculating a time when the fluorescence intensity satisfies a prescribed criterion based on the measureType: GrantFiled: May 23, 2000Date of Patent: April 1, 2003Assignee: Tosoh CorporationInventors: Akihiro Yokoyama, Takahiko Ishiguro, Juichi Saitoh
-
Patent number: 6528679Abstract: A phenyl ester is produced by allowing benzene, a carboxylic acid and molecular oxygen to react with each other in the presence of a catalyst comprising (A) palladium, (B) at least one element selected from elements of groups 13, 14, 15, and 16 and the fourth to sixth periods of the periodic table, and (C) at least one element selected from elements of groups 3, 4 and lanthanoid elements of the periodic table. Preferably, element (B) is selected from elements of group 16 and the fourth to sixth periods of the periodic table, and element (C) is contained in a metal oxide form in the catalyst. The phenyl ester can be converted to phenol by hydrolysis or ester exchange.Type: GrantFiled: September 27, 2000Date of Patent: March 4, 2003Assignee: Tosoh CorporationInventors: Yoshihiko Mori, Takao Doi, Tetsuo Asakawa, Takanori Miyake
-
Patent number: 6468541Abstract: The invention concerns an immune system stimulator comprising Hericium, Radix Astragali, Cordyceps Sinensus, Radix Glycyrrhizae and Dioscoreae Oppositae. The composition is capable of mediating enhanced production of Interleukin-1 beta without causing an increase in the production of Interleukin-4.Type: GrantFiled: June 21, 2001Date of Patent: October 22, 2002Assignee: Chinese Herbal USA, Inc.Inventor: Paul Y. S. Lam
-
Patent number: 6464982Abstract: The invention concerns an immune system stimulator comprising Ganoderma Lucidum, Dioscoreae Oppositae, Chrysanthemum Morifolium, Radix Astragali, and Folium Isatidis. The composition is capable of mediating enhanced production of Interleukin-1 beta without causing an increase in the production of Interleukin-4.Type: GrantFiled: November 2, 2001Date of Patent: October 15, 2002Assignee: Chinese Herbal USA, Inc.Inventor: Paul Y. S. Lam
-
Patent number: 6451543Abstract: The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis.Type: GrantFiled: August 26, 1999Date of Patent: September 17, 2002Assignee: Gryphon SciencesInventors: Gerd. G. Kochendoerfer, Christie L. Hunter, Stephen B. H. Kent, Paolo Botti
-
Patent number: 6448017Abstract: Methods and compositions suitable for accomplishing the in vitro amplification of nucleic acid molecules via enzymatic means are provided. The preferred means employ circular rather than linear replicons. Means for producing such circular replicons from linear reactants are also provided.Type: GrantFiled: July 9, 2001Date of Patent: September 10, 2002Assignee: Replicon, Inc.Inventor: Jeffrey I. Auerbach
-
Patent number: 6261808Abstract: Methods and compositions suitable for accomplishing the in vitro amplification of nucleic acid molecules via enzymatic means are provided. The preferred means employ circular rather than linear replicons. Means for producing such circular replicons from linear reactants are also provided.Type: GrantFiled: September 8, 2000Date of Patent: July 17, 2001Assignee: Replicon, Inc.Inventor: Jeffrey I. Auerbach
-
Patent number: 6218152Abstract: Methods and compositions suitable for accomplishing the in vitro amplification of nucleic acid molecules via enzymatic means are provided. The preferred means employ circular rather than linear replicons. Means for producing such circular replicons from linear reactants are also provided.Type: GrantFiled: November 9, 1998Date of Patent: April 17, 2001Assignee: Replicon, Inc.Inventor: Jeffrey I. Auerbach
-
Patent number: 6180338Abstract: Methods and reagents for the detection and exponential amplification of target nucleic acid molecules are disclosed. The method generally employs a Primer Oligonucleotide which hybridizes in concert with a Blocker Oligonucleotide on a strand of the target molecule, and an End-Run Oligonucleotide which can hybridize to the Blocker Oligonucleotide.Type: GrantFiled: May 27, 1993Date of Patent: January 30, 2001Assignee: Beckman Coulter, Inc.Inventor: Craig W. Adams