Patents Represented by Attorney, Agent or Law Firm Jeffrey I. Auerbach
  • Patent number: 7063918
    Abstract: The present invention relates to a unique polymeric battery system of electrochemical cells that are connected in series, and can be of nanometer size. The polymers possess conjugated bonds along their backbones and high levels of metals. The invention also concerns methods for the fabrication of the polymers and battery system as well as methods for the use of the polymers as a nanoscale solid-state battery.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: June 20, 2006
    Assignee: The University of Maryland, College Park
    Inventors: Peter Kofinas, Steven Bullock
  • Patent number: 7049560
    Abstract: A tape heater includes an electric heating wire disposed on a surface of a heat-resistant, flexible substrate strip. The electric heating wire and the substrate strip are wrapped with a heat-resistant resin wrap.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: May 23, 2006
    Assignee: Nichias Corporation
    Inventors: Keiichi Fukuda, Yoshiyuki Motoyoshi
  • Patent number: 7010751
    Abstract: The present invention provides software for electronically annotating electronic images, such as drawings, photographs, video, etc., through the drag-and-drop of annotations from a pre-defined, but extendable, list. The annotations are placed at a user-selected X, Y location on the image, and stored in a searchable database. Thus, they can be searched in order to retrieve, organize, group, or display desired electronic images or collections of such images. The annotations may be text, images, sounds, etc. The invention provides a flexible, easy to learn, rapid, low error rate and satisfying interface for accomplishing such tasks.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: March 7, 2006
    Assignee: University of Maryland, College Park
    Inventor: Ben A. Shneiderman
  • Patent number: 6815394
    Abstract: A phenyl ester is produced by allowing benzene, a carboxylic acid and molecular oxygen to react with each other in the presence of a catalyst comprising (A) palladium, (B) at least one element selected from elements of groups 13, 14, 15, and 16 and the fourth to sixth periods of the periodic table, and (C) at least one element selected from elements of groups 3, 4 and lanthanoid elements of the periodic table. Preferably, element (B) is selected from elements of group 16 and the fourth to sixth periods of the periodic table, and element (C) is contained in a metal oxide form in the catalyst.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: November 9, 2004
    Assignee: Tosoh Corporation
    Inventors: Yoshihiko Mori, Takao Doi, Tetsuo Asakawa, Takanori Miyake
  • Patent number: 6780413
    Abstract: Compositions and methods for treatment of focal muscle spasms. Immunotoxin conjugates comprise a toxin conjugated to an antibody reactive to a muscle specific antigen.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: August 24, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jonathan S. Hott, Richard J. Youle, Mark Hallett, Marinos C. Dalakas
  • Patent number: 6706528
    Abstract: The present invention generally relates to analytical elements and methods for the selective determination of magnesium. In particular, the present invention is further directed to carboxy-quinolizine suitable for use as magnesium indicators, and more particularly, to 4-oxo-4H-quinolizine-3-carboxylic acid derivatives for use as novel fluorescent magnesium indicators.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: March 16, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert E. London, Pieter Otten, Louis A. Levy
  • Patent number: 6673347
    Abstract: Protein and polypeptide derivatives and their salts are claimed characterized in that a protein or polypeptide is conjugated via an intermediate grouping containing at least one radical of the formula —C(R)═N— (or —N═C(R)—) or —CH(R)—NH— (or —NH—CH(R)—), wherein R is hydrogen or a hydrocarbon residue which may be substituted, with the same or a different protein or polypeptide, with a reporter group or a cytotoxic agent as well as a process for their preparation and the novel intermediates therefor.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: January 6, 2004
    Assignee: Gryphon Therapeutics
    Inventors: Robin Ewart Offord, Keith Rose
  • Patent number: 6663869
    Abstract: A homogeneous polyoxime composition is provided, in which the polyoxime molecules present comprise a first organic baseplate molecule, which is a polypeptide, wherein the baseplate molecule is linked to at least two second organic molecules, which may be the same or different from one another. In the compositions, the linkages between the baseplate and said organic molecules are oxime linkages formed by reaction of an orthogonal reactive group on each the organic molecules with a complementary orthogonal reactive group on the baseplate.
    Type: Grant
    Filed: August 4, 2000
    Date of Patent: December 16, 2003
    Assignee: Gryphon Therapeutics, Inc.
    Inventors: Keith Rose, Robin E. Offord
  • Patent number: 6599644
    Abstract: A method of producing an ohmic contact to p-type silicon carbide comprising two layers, the first one comprising nickel silicide and the second one comprising titanium carbide is disclosed. The deposited layers are annealed to convert at least a part of deposited metals to nickel silicide and titanium carbide. The contact is formed by reaction between the metals and the semiconductor, and thus the in-situ simultaneous formation of metal silicide and carbide suppress the release of excess carbon at the contact interface. Noble metals may be deposited preferably in between titanium and nickel to improve the contact morphology.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: July 29, 2003
    Assignee: Foundation for Research & Technology-Hellas
    Inventors: Konstantinos Zekentes, Konstantin V. Vassilievski
  • Patent number: 6562955
    Abstract: An oligonucleotide for detection or amplification of a gene selected from the group consisting of Vibrio parahaemolyticus thermostable direct hemolysin-related hemolysin genes (trh1 and trh2) and Vibrio parahaemolyticus thermostable direct hemolysin gene (tdh2) or RNA derived therefrom is provided. Further, method for detecting trh1, trh2 or tdh2 using said oligonucleotide is provided.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: May 13, 2003
    Assignee: Tosoh Corporation
    Inventors: Tetsuya Ishizuka, Takahiko Ishiguro, Juichi Saitoh
  • Patent number: 6552167
    Abstract: Provided are chains of precise length and methods for their preparation. These chains are formed by the reaction of a derivative of a diacid and a diamine in a stepwise manner on a support. One of the reactants contains a water soluble oligomer, preferably polyethylene glycol. These chains are then used to chemically modify target macromolecules such as biologically important polypeptides.
    Type: Grant
    Filed: August 23, 1999
    Date of Patent: April 22, 2003
    Assignee: Gryphon Therapeutics, Inc.
    Inventor: Keith Rose
  • Patent number: 6541205
    Abstract: A method for assaying a target nucleic acid, comprising: providing an RNA amplification system comprising producing a double-stranded DNA using, as a template, a target RNA containing a specific nucleotide sequence in a sample, said double-stranded DNA having a promoter sequence and being capable of transcribing an RNA comprising the specific nucleotide sequence or a sequence complementary to the specific nucleotide sequence, producing an RNA transcription product comprising the specific nucleotide sequence or a sequence complementary to the specific nucleotide sequence in the presence of an RNA polymerase, and producing the double-stranded DNA using the RNA transcription product as a template, in the presence of a probe labeled with an intercalating fluorochrome having a sequence complementary to the RNA transcription product; measuring the fluorescence intensity in the RNA amplification system with time; calculating a time when the fluorescence intensity satisfies a prescribed criterion based on the measure
    Type: Grant
    Filed: May 23, 2000
    Date of Patent: April 1, 2003
    Assignee: Tosoh Corporation
    Inventors: Akihiro Yokoyama, Takahiko Ishiguro, Juichi Saitoh
  • Patent number: 6528679
    Abstract: A phenyl ester is produced by allowing benzene, a carboxylic acid and molecular oxygen to react with each other in the presence of a catalyst comprising (A) palladium, (B) at least one element selected from elements of groups 13, 14, 15, and 16 and the fourth to sixth periods of the periodic table, and (C) at least one element selected from elements of groups 3, 4 and lanthanoid elements of the periodic table. Preferably, element (B) is selected from elements of group 16 and the fourth to sixth periods of the periodic table, and element (C) is contained in a metal oxide form in the catalyst. The phenyl ester can be converted to phenol by hydrolysis or ester exchange.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: March 4, 2003
    Assignee: Tosoh Corporation
    Inventors: Yoshihiko Mori, Takao Doi, Tetsuo Asakawa, Takanori Miyake
  • Patent number: 6468541
    Abstract: The invention concerns an immune system stimulator comprising Hericium, Radix Astragali, Cordyceps Sinensus, Radix Glycyrrhizae and Dioscoreae Oppositae. The composition is capable of mediating enhanced production of Interleukin-1 beta without causing an increase in the production of Interleukin-4.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: October 22, 2002
    Assignee: Chinese Herbal USA, Inc.
    Inventor: Paul Y. S. Lam
  • Patent number: 6464982
    Abstract: The invention concerns an immune system stimulator comprising Ganoderma Lucidum, Dioscoreae Oppositae, Chrysanthemum Morifolium, Radix Astragali, and Folium Isatidis. The composition is capable of mediating enhanced production of Interleukin-1 beta without causing an increase in the production of Interleukin-4.
    Type: Grant
    Filed: November 2, 2001
    Date of Patent: October 15, 2002
    Assignee: Chinese Herbal USA, Inc.
    Inventor: Paul Y. S. Lam
  • Patent number: 6451543
    Abstract: The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis.
    Type: Grant
    Filed: August 26, 1999
    Date of Patent: September 17, 2002
    Assignee: Gryphon Sciences
    Inventors: Gerd. G. Kochendoerfer, Christie L. Hunter, Stephen B. H. Kent, Paolo Botti
  • Patent number: 6448017
    Abstract: Methods and compositions suitable for accomplishing the in vitro amplification of nucleic acid molecules via enzymatic means are provided. The preferred means employ circular rather than linear replicons. Means for producing such circular replicons from linear reactants are also provided.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: September 10, 2002
    Assignee: Replicon, Inc.
    Inventor: Jeffrey I. Auerbach
  • Patent number: 6261808
    Abstract: Methods and compositions suitable for accomplishing the in vitro amplification of nucleic acid molecules via enzymatic means are provided. The preferred means employ circular rather than linear replicons. Means for producing such circular replicons from linear reactants are also provided.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: July 17, 2001
    Assignee: Replicon, Inc.
    Inventor: Jeffrey I. Auerbach
  • Patent number: 6218152
    Abstract: Methods and compositions suitable for accomplishing the in vitro amplification of nucleic acid molecules via enzymatic means are provided. The preferred means employ circular rather than linear replicons. Means for producing such circular replicons from linear reactants are also provided.
    Type: Grant
    Filed: November 9, 1998
    Date of Patent: April 17, 2001
    Assignee: Replicon, Inc.
    Inventor: Jeffrey I. Auerbach
  • Patent number: 6180338
    Abstract: Methods and reagents for the detection and exponential amplification of target nucleic acid molecules are disclosed. The method generally employs a Primer Oligonucleotide which hybridizes in concert with a Blocker Oligonucleotide on a strand of the target molecule, and an End-Run Oligonucleotide which can hybridize to the Blocker Oligonucleotide.
    Type: Grant
    Filed: May 27, 1993
    Date of Patent: January 30, 2001
    Assignee: Beckman Coulter, Inc.
    Inventor: Craig W. Adams