Patents Represented by Attorney Jeffrey M. Libby
  • Patent number: 8283519
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, variants of naturally-occurring sequences, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties, including improved cold and other osmotic stress tolerance, as compared to wild-type or reference plants. The invention also pertains to expression systems that may be used to regulate these transcription factor polynucleotides, providing constitutive, transient, inducible and tissue-specific regulation.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: October 9, 2012
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Robert A. Creelman, Oliver Ratcliffe, Roderick W. Kumimoto, Neal I. Gutterson, T. Lynne Reuber, Jeffrey M. Libby, Jacqueline E. Heard, Jose Luis Riechmann, Omaira Pineda
  • Patent number: 8110725
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: February 7, 2012
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Jose Luis Riechmann, Jacqueline E. Heard, Oliver Ratcliffe, T. Lynne Reuber
  • Patent number: 8030546
    Abstract: Transcription factor polynucleotides and polypeptides incorporated into nucleic acid constructs, including expression vectors, have been introduced into plants and were ectopically expressed. Transgenic plants transformed with many of these constructs have been shown to be more resistant to disease (in some cases, to more than one pathogen), or more tolerant to an abiotic stress (in some cases, to more than one abiotic stress). The abiotic stress may include, for example, salt, hyperosmotic stress, water deficit, heat, cold, drought, or low nutrient conditions.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: October 4, 2011
    Assignee: Mendel Biotechnology, Inc.
    Inventors: T. Lynne Reuber, Oliver Ratcliffe, Karen S. Century, Neal I. Gutterson, Roger Canales, Emily L. Queen
  • Patent number: 7994394
    Abstract: Disease-inducible promoter sequences have been identified that may be used to produce transgenic plants that are both more resistant to disease than control plants, and are wild-type or nearly wild type in appearance. Any of these disease-inducible promoters may be incorporated into expression vectors that each comprise a defense response protein operably linked to the promoter. The expression vectors can be introduced into plants and the defense response protein then ectopically expressed. Transgenic plants transformed with many of these expression vectors have been shown to be more resistant to disease, in some cases, to more than one type of pathogen, and yet are similar to wild type plants in their morphology and development.
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: August 9, 2011
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Luc Adam, T. Lynne Reuber, Karen S. Century
  • Patent number: 7897843
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties, including increased biomass or improved cold or other osmotic stress tolerance, as compared to wild-type or reference plants. The invention also pertains to expression systems that may be used to regulate these transcription factor polynucleotides, providing constitutive, transient, inducible and tissue-specific regulation.
    Type: Grant
    Filed: June 16, 2004
    Date of Patent: March 1, 2011
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Cai-Zhong Jiang, Jacqueline E. Heard, Oliver Ratcliffe, Neal I. Gutterson, Frederick D. Hempel, Roderick W. Kumimoto, James S. Keddie, Bradley K. Sherman, Jeffrey M. Libby, Jindong Sun, Kimberly Faye Zobrist-Duff, Jingrui Wu, Changlin Fu, Stanton B. Dotson, Linda L. Lutfiyya
  • Patent number: 7888558
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties, tolerance low nitrogen, cold and water deficit conditions, and resistance to disease, as compared to wild-type or other control plants.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: February 15, 2011
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Neal I. Gutterson, Oliver Ratcliffe, Emily L. Queen, T. Lynne Reuber, Karen S. Century, Roger Canales
  • Patent number: 7868229
    Abstract: The present invention provides polynucleotides encoding CCAAT-binding transcription factor polypeptides that modulate the onset of reproductive development in plants. Polynucleotides encoding functional CCAAT-binding transcription factors were incorporated into expression vectors, introduced into plants, and ectopically expressed. The encoded polypeptides of the invention significantly shortened the time to flower development in the transgenic plants, as compared to the flowering time of control plants.
    Type: Grant
    Filed: February 12, 2007
    Date of Patent: January 11, 2011
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Oliver Ratcliffe, Roderick W. Kumimoto, Peter P. Repetti, T. Lynne Reuber, Robert Creelman, Frederick D. Hempel
  • Patent number: 7692067
    Abstract: Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the invention have been shown to confer at least one regulatory activity and confer increased yield, greater height, greater early season growth, greater canopy coverage, greater stem diameter, greater late season vigor, increased secondary rooting, more rapid germination, greater cold tolerance, greater tolerance to water deprivation, reduced stomatal conductance, altered C/N sensing, increased low nitrogen tolerance, increased low phosphorus tolerance, or increased tolerance to hyperosmotic stress as compared to the control plant as compared to a control plant.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: April 6, 2010
    Assignees: Mendel Biotechnology, Inc., Monsanto Company
    Inventors: Robert Creelman, Neal I. Gutterson, Oliver Ratcliffe, T. Lynne Reuber, R. Eric Cerny, Kimberly Faye Zobrist Duff, Susanne Kjemtrup-Lovelace, Robert Meister, Marie Petracek, Thomas Ruff, Qingzhang Xu
  • Patent number: 7663025
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having improved tolerance to drought, shade, and low nitrogen conditions, as compared to wild-type or reference plants.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: February 16, 2010
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Jacqueline E. Heard, Jose Luis Riechmann, Robert A. Creelman, Oliver Ratcliffe, Roger D. Canales, Neal I. Gutterson, T. Lynne Reuber, Omaira Pineda, Tracy A. Morrison, Cai-Zhong Jiang, Karen S. Century
  • Patent number: 7659446
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods is also disclosed.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: February 9, 2010
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Bradley K. Sherman, Jose Luis Riechmann, Oliver Ratcliffe, Cai-Zhong Jiang, Jacqueline Heard, Volker Haake, Robert A. Creelman, Luc J. Adam, Lynne Reuber, James S. Keddie, Arnold Dubell, Omaira Pineda, Peter P. Repetti, Karen S. Century, Neal Gutterson, Guo-Liang Yu, Pierre Broun, Roderick Kumimoto, Marsha L. Pilgrim
  • Patent number: 7601893
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: October 13, 2009
    Assignee: Mendel Biotechnology, Inc.
    Inventors: T. Lynne Reuber, Jose Luis Riechmann, Jacqueline E. Heard, Cai-Zhong Jiang, Luc Adam, Arnold N. Dubell, Oliver Ratcliffe, Omaira Pineda, Guo-Liang Yu, Pierre Broun
  • Patent number: 7598429
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference or control plant, including increased plant size, seed size, increased leaf size, lignification, water deprivation tolerance, cold tolerance, or altered flowering time. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: October 6, 2009
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Jacqueline E. Heard, Jose Luis Riechmann, Oliver Ratcliffe, Omaira Pineda
  • Patent number: 7345217
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: March 18, 2008
    Assignee: Mendel Biotechnology, Inc.
    Inventors: James Zhang, Michael E. Fromm, Jacqueline E. Heard, Jose Luis Riechmann, Luc Adam, Pierre E. Broun, Omaira Pineda, T. Lynne Reuber, James Keddie, Guo-Liang Yu, Cai-Zhong Jiang, Raymond Samaha, Marsha L. Pilgrim, Robert A. Creelman, Arnold N. DuBell, Oliver Ratcliffe, Roderick Kumimoto, Bradley K. Sherman
  • Patent number: 7135616
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: November 14, 2006
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Jacqueline E. Heard, Jose Luis Riechmann, Robert A. Creelman, James Keddie, Marsha L. Pilgrim, Arnold N. DuBell, Cai-Zhong Jiang, Oliver Ratcliffe, Omaira Pineda, Guo-Liang Yu, Pierre E. Broun
  • Patent number: 6946586
    Abstract: A method for screening for a trait associated with the altered expression of a gene of interest in plants is provided. The method is a combinatorial approach which uses traditional plant breeding techniques for modifying the patterns of expression of a gene of interest. Kits for use in the method and transgenic plants generated by the method are also provided.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: September 20, 2005
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Michael Fromm, James Zhang
  • Patent number: 6835540
    Abstract: The present invention provides a high-throughput method for identifying a polynucleotide which encodes a transcription factor for controlling the expression of one or more genes in a pathway. In particular, the method is useful for identifying a transcription factor for controlling a gene in a biosynthetic pathway. The invention further provides polynucleotides encoding such transcription factors for controlling the expression of a gene in a biosynthetic pathway, transgenic cells expressing at least one such polynucleotide, and methods for isolating metabolites from such cells or plants.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: December 28, 2004
    Assignee: Mendel Biotechnology, Inc.
    Inventor: Pierre Broun
  • Patent number: 6717034
    Abstract: Recombinant polynucleotides and methods for modifying the phenotype of a plant are provided. In particular, the phenotype that is being modified is a plant's biomass. The method comprises altering the levels of a transcription factor that is introduced into the plant or that is endogenous to the plant to obtain a plant with a larger biomass.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: April 6, 2004
    Assignee: Mendel Biotechnology, Inc.
    Inventor: Cai-Zhong Jiang
  • Patent number: 6706866
    Abstract: The present invention provides for a non-naturally occurring binding protein comprising an amino acid sequence capable of binding to a CCG regulatory sequence and an amino acid sequence which forms a transcription activation region. In particular the invention comprises a sequence selected from the group consisting of an AP2 domain of SEQ. I.D. Nos. 13, 15, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, and 95. When these proteins are overexpressed in a plant the plant exhibits increased tolerance to environmental stresses such as cold, freezing, drought or high salinity.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: March 16, 2004
    Assignee: Michigan State University
    Inventors: Michael Thomashow, Sarah Jane Gilmour, Cai-Zhong Jiang, Michael Fromm, Daniel Zarka, Kirsten Jaglo-Ottosen, Eric J. Stockinger, James Zhang, Volker Haake
  • Patent number: 6664446
    Abstract: Plants transformed with a plant APZ transcription factor encoding polynucleotide, isolated from Arabidopsis, that enhances tolerance to fungal diseases, especially fungal diseases caused by Fusarium, Erysiphe, Sclerotinia and Botrytis.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: December 16, 2003
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Jacqueline Heard, Pierre Broun, Jose Luis Riechmann, James Keddie, Omaira Pineda, Luc Adam, Raymond Samaha, James Zhang, Guo-Liang Yu, Oliver Ratcliffe, Marsha Pilgrim, Cai-Zhong Jiang, Lynne Reuber
  • Patent number: 6472415
    Abstract: Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. The compounds bind specifically to the androgen receptor and find use in indications associated with the androgen receptor, such as cell hyperplasia dependent on androgens, hirsutism, acne and androgenetic alopecia.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: October 29, 2002
    Assignee: Biophysica, Inc.
    Inventors: Milos Sovak, Allen L. Seligson, James Gordon Douglas, III, Brian Campion, Jason W. Brown