Patents Represented by Attorney, Agent or Law Firm Jeffrey S. Boone
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Patent number: 6559319Abstract: A multi-step method of synthesizing ketorolac, an analgesic compound, is shown. Several of the reactions and intermediate compounds are novel. The reaction sequence begins with the known compound N-2-bromoethylpyrrole.Type: GrantFiled: September 3, 2002Date of Patent: May 6, 2003Assignee: Mallinckrodt Inc.Inventors: Douglas C. Caskey, John R. Duchek, Henry J. Buehler
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Patent number: 6489491Abstract: A multi-step method of synthesizing ketorolac, an analgesic compound, is shown. Several of the reactions and intermediate compounds are novel. The reaction sequence begins with the known compound N-2-bromoethylpyrrole.Type: GrantFiled: February 5, 2002Date of Patent: December 3, 2002Assignee: Mallinckrodt Inc.Inventors: Douglas C. Caskey, John R. Duchek, Henry J. Buehler
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Patent number: 6450936Abstract: A manifold system allows for the movement of a radioactive fluid from a container to a treatment balloon or other device, and the withdrawal of the radioactive fluid from the treatment device. The system allows for the convenient movement of the fluid, with minimal radiation exposure for those using the system. The manifold system is particularly useful in the use of radiation to prevent restenosis of arteries.Type: GrantFiled: April 27, 2000Date of Patent: September 17, 2002Assignee: Mallinckrodt Inc.Inventors: Edward F. Smith, III, David W. Pipes, James G. Schnieder
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Patent number: 6376681Abstract: This invention relates to the drug, ketorolac and the synthesis of compounds useful in the manufacture of ketorolac. Ketorolac tromethamine is a pharmaceutical compound useful as an analgesic.Type: GrantFiled: December 6, 2000Date of Patent: April 23, 2002Assignee: Mallinckodt Inc.Inventors: John R. Duchek, Henry J. Buehler, Douglas C. Caskey
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Patent number: 6308826Abstract: A packaging system and method is provided which will substantially retard or reduce the caking of powdered, crystalline, or granular organic and inorganic cakable chemical compounds and mixtures thereof. Such retardation and reduction in caking enhances the free flowability and scoopability of the compound. The packaging system and method comprises a moisture impermeable container which may include a moisture impermeable cover which closes the container, providing a moisture tight seal to close the container, and desiccant. The compound can be placed directly into the container or into a moisture permeable bag which is sealed after the compound has been placed therein. The bag is filled or sized so that there will be a void space in the container once the container is closed. The desiccant is placed in the void space. The drum may be a fiber board drum having a moisture impermeable liner, such as an aluminum liner. The cover is preferably a plastic cover.Type: GrantFiled: June 2, 1999Date of Patent: October 30, 2001Assignee: Mallinckrodt Inc.Inventor: Phillip H. Merrell
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Patent number: 6102198Abstract: A packaging system and method is provided which will substantially retard or reduce the caking of powdered, crystalline, or granular organic and inorganic cakable chemical compounds and mixtures thereof. Such retardation and reduction in caking enhances the free flowability and scoopability of the compound. The packaging system and method comprises a moisture impermeable container, a moisture impermeable cover which closes the container, providing a moisture tight seal between the container and cover such as with a gasket, and desiccant. The compound can be placed directly into the container or into a moisture permeable bag which is sealed after the compound has been placed therein. The bag is filled or sized so that there will be a void space in the container once the container is closed. The desiccant is placed in the void space. The drum may be a fiber board drum having a moisture impermeable liner, such as an aluminum liner. The cover is preferably a plastic cover.Type: GrantFiled: May 22, 1997Date of Patent: August 15, 2000Assignee: Mallinckrodt Inc.Inventor: Philip H. Merrell
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Patent number: 5830431Abstract: This invention relates to radiolabeled peptide compositions for radiopharmaceutical use and, more specifically, to radiolabeled peptides for diagnostic or therapeutic use having an unmodified carboxy terminal amino acid. The radiopharmaceutical composition may be used for targeting a selected biological site. The radiolabeled peptide is characterized by having its carboxy terminal amino acid in its carboxylic acid form and the peptide is coupled to a diagnostic or therapeutic radionuclide by a chelating agent. The radiopharmaceutical composition preferably comprises a radiolabeled peptide selected from the group consisting of somatostatin, an analog of somatostatin, a derivative of somatostatin and peptides capable of binding to the somatostatin receptor, where the peptide is coupled to a diagnostic or therapeutic radionuclide by a chelating agent has its carboxy terminal amino acid in its carboxylic acid form.Type: GrantFiled: June 7, 1995Date of Patent: November 3, 1998Assignee: Mallinckrodt Medical, Inc.Inventors: Ananthachari Srinivasan, Mary Marmion Dyszlewski, Joseph E. Bugaj, Jack L. Erion
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Patent number: 5756745Abstract: A process is described for the synthesis of nalbuphine. The process results in a product having very low levels of the undesirable .beta.-epimer. The process is a five-step synthesis that begins with a compound such as an N,O.sup.3 -bis (alkoxycarbonyl) -14-hydroxynormorphinone.Type: GrantFiled: November 26, 1996Date of Patent: May 26, 1998Assignee: Mallinckrodt Medical, Inc.Inventor: Frank Kavka
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Patent number: 5752603Abstract: The invention relates to a reservoir for at least one capsule for oral administration which comprises a substance which is dangerous for the environment, in particular a radioactive composition, which reservoir can be enclosed within an at least substantially cylindrical shielding sleeve, has a closed bottom and can be closed at its open upper end by means of a cap, the reservoir internally comprising a plurality of longitudinal ribs. The reservoir is prefereably constructed so that it is locked against rotation within the shielding sleeve. The invention further relates to a shielded holder comprising the last-mentioned locked reservoir and a shielding sleeve having a bottom portion with an internal cross-section which is triangular to dodecagonal or forms a segment of a circle.Type: GrantFiled: November 22, 1996Date of Patent: May 19, 1998Assignee: Mallinckrodt Medical, Inc.Inventor: Mathijs Faber
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Patent number: 5741476Abstract: The invention relates to polyhydric phenol compounds of the general formula ##STR1## wherein R is a hydrogen atom or a saccharide moiety;A and B are hydrogen atoms or form together a C--C bond;R.sub.1 is a hydroxy group and R.sub.2 is a hydrogen atom, orR.sub.1 and R.sub.2 form together an oxygen atom;Z is a hydroxy group, an amino group, a carboxy group or a N-(carboxymethyl)carbamoyl group;X* is a radioactive halogen isotope; andm and n are 0 or 1, with the proviso, that m is 1 if n is 0, and that m is 0 if n is 1.The radiolabelled phenol compounds can be used for diagnosis and therapy.Type: GrantFiled: June 20, 1995Date of Patent: April 21, 1998Assignee: Mallinckrodt Medical, Inc.Inventor: John Janine Rene Mertens
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Patent number: 5396011Abstract: An aromatic compound (such as benzene) is alkylated with a alkene (such as propylene) by contacting the two compounds together in the presence of a tungsten on zirconia catalyst. The reaction preferably takes place at elevated temperature and elevated pressure. The process of the invention has very high selectivity and conversion, and produces no or only very low amounts of undesirable oligomers (as measured by bromine number).Type: GrantFiled: December 28, 1992Date of Patent: March 7, 1995Assignee: Mallinckrodt Chemical, Inc.Inventor: Deborah K. Kuhn
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Patent number: 5284576Abstract: Hydrocarbons, gas mixtures of hydrocarbons, and the like containing hydrogen sulfide are brought into intimate contact with a hydrogen sulfide scavenger prepared by reacting an alkylenepolyamine with formaldehyde, whereby the amount of hydrogen sulfide in the hydrocarbon is significantly reduced.Type: GrantFiled: March 12, 1993Date of Patent: February 8, 1994Assignee: Petrolite CorporationInventors: Jerry J. Weers, Timothy J. O'Brien
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Patent number: 5266185Abstract: Hydrogen sulfide evolution in a heavy hydrocarbon (such as a residual fuel oil) derived from a heavy crude oil (such as a API 8 gravity crude) is suppressed by contacting the hydrocarbon with a compound corresponding to the reaction product of a heterocyclic aldehyde (such as furfural) and an organic primary amine.Type: GrantFiled: September 10, 1990Date of Patent: November 30, 1993Assignee: Petrolite CorporationInventors: Jerry J. Weers, Timothy J. O'Brien, Catherine E. Thomasson
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Patent number: 5254776Abstract: Bromobiphenyls (such as 2-fluoro-4-bromobiphenyl) are synthesized by reacting together a phenylboronic acid (such as phenylboronic acid) and a bromoiodobenzene (such as 2-fluoro-4-bromoiodobenzene). The reaction generally takes place with the aid of a catalyst (such as palladium in a zero valance state) and an inert solvent (such as fluorobenzene). Control of temperature is very important to obtain both an acceptable reaction rate and an acceptable level of terphenyl byproduct.Type: GrantFiled: July 17, 1992Date of Patent: October 19, 1993Assignee: Mallinckrodt Specialty Chemicals CompanyInventors: John F. Lang, Narayanasamy Gurusamy
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Patent number: 5252289Abstract: Water-soluble 1,2-dithiole-3-thione derivatives are prepared by reacting a polyoxyalkylated starting material with sulfur. These derivatives are useful as corrosion inhibitors, particularly in aqueous environments.Type: GrantFiled: January 11, 1993Date of Patent: October 12, 1993Assignee: Petrolite CorporationInventor: Bernardus A. Oude Alink
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Patent number: 5160642Abstract: A clayish formation, such as encountered in rock surrounding an oil well bore, is stabilized with a quaternary ammonium salt of an imide of polymaleic anhydride. The invention is particularly relevant to hydraulic fracturing fluids used for enhanced oil recovery.Type: GrantFiled: May 25, 1990Date of Patent: November 3, 1992Assignee: Petrolite CorporationInventors: John A. Schield, Michael I. Naiman, Gary A. Scherubel
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Patent number: 5110874Abstract: A method for reducing friction loss in flowing hydrocarbon fluids is disclosed. The method comprises adding to the fluid an effective amount of an oil-soluble polyamine and a terpolymer of styrene, alkyl acrylate and a carboxylic acid selected from the group consisting of acrylic acid and methacrylic acid. Related compositions are also disclosed.Type: GrantFiled: April 19, 1990Date of Patent: May 5, 1992Assignee: Petrolite CorporationInventors: Michael I. Naiman, James C. Chang
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Patent number: 5089611Abstract: An alkyl 2-thiosubstituted-3-substituted-2-butenoate ##STR1## is prepared by reacting an alkyl 2-chloro-3-substituted-3-butenoate with a thio compound under phase transfer conditions.Type: GrantFiled: March 12, 1990Date of Patent: February 18, 1992Assignee: Petrolite CorporationInventor: Jacob Mathew
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Patent number: 5074991Abstract: Hydrogen sulfide gas evolution from water or hydrocarbons, especially during storage or transport of petroleum residua is suppressed by the incorporation of an effective amount of a diamine of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are independently an alky radical containing 1 to 14 carbon atoms, (CH.sub.2).sub.n --OR.sub.6 or cycloalkyl containing 5 or 6 carbon atoms and R.sub.5 is hydrogen or methyl. R.sub.1 and R.sub.2 and R.sub.3 and R.sub.4 can be alkylene groups joined together with their respective adjacent N to form a heterocyclic ring. R.sub.6 is hydrogen or an alkyl radical having 1 to 5 carbon atoms and n is an integer of 1 to 5.Type: GrantFiled: May 18, 1990Date of Patent: December 24, 1991Assignee: Petrolite CorporationInventor: Jerry J. Weers
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Patent number: 5047069Abstract: An antioxidant for liquid hydrocarbons such as fuels has the structure ##STR1## wherein X is N or S; R is H or a C.sub.1 to C.sub.5 alkyl moiety; R.sup.1 and R.sup.2 are each independently C.sub.5 to C.sub.18 alkyl or cycloalkyl moieties (which may optionally contain a hetero atom such as oxygen), only one of R.sup.1 and R.sup.2 being present if X is S, or may be combined to form a 5 or preferably 6 membered ring; each R.sup.6 is independently the residue of a C.sub.1 to C.sub.5 aldehyde; and R.sup.7 is the residue of a polyamine of the formula ##STR2## wherein R.sup.3 is a C.sub.8 to C.sub.50 alkyl moiety (which may optionally contain one or more ether linkages); R.sup.4 and R.sup.5 are each independently C.sub.2 to C.sub.6 alkylene moieties; a is 0 or 1; and m is at least 3.Type: GrantFiled: October 22, 1990Date of Patent: September 10, 1991Assignee: Petrolite CorporationInventors: Jerry J. Weers, Thomas V. Bagwell