Patents Represented by Attorney Jennifer Kispert
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Patent number: 7838686Abstract: Materials and Methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.Type: GrantFiled: October 20, 2008Date of Patent: November 23, 2010Assignee: Pfizer Inc.Inventors: Shanghui Hu, Carlos Alberto Martinez, Junhua Tao, William Eugene Tully, Patrick Kelleher, Yves Dumond
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Patent number: 7834279Abstract: A weighing apparatus comprising a weighing pan (20) for supporting on an upper surface thereof an object (21) to be weighed, a support for the weighing pan (20), the support contacting a lower surface of the weighing pan and comprising an elongate member (23) extending downwardly from the weighing pan (20), the elongate member (23) extending through a hole (24) provided in a floor (36), located beneath the weighing pan (20), of a weighing pan region of the apparatus, a weighing mechanism (44) located beneath the floor (36) of the weighing pan region in a weighing mechanism region of the apparatus, the elongate member (23) connecting with the weighing mechanism, and a drive means (28) for selectively moving the weighing pan (20) between an upper position, at which the weighing pan (20) is spaced from the floor (36), and a lower position, at which the weighing pan (20) contacts the floor (36) in a sealing relationship for preventing material in the weighing pan region from passing through the hole (24) into theType: GrantFiled: August 9, 2005Date of Patent: November 16, 2010Assignee: Pfizer IncInventor: Donald Bruce Atherton Macmichael
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Patent number: 7829572Abstract: The present invention is directed to novel pyrido[4,3-d]pyrimidin-4(3H)-one derivatives and pharmaceutically acceptable salts thereof of structural formula I wherein the variables R1, R2, R3, R4 and R5 are as described herein. Also provided are pharmaceutical compositions comprising the compounds of formula I as well as methods of treatment employing compounds of formula I to treat a disease or disorder characterized by abnormal bone or mineral homeostasis such as hypoparathyroidism, osteoporosis, osteopenia, periodontal disease, Paget's disease, bone fracture, osteoarthritis, rheumatoid arthritis, and humoral hypercalcemia of malignancy.Type: GrantFiled: October 4, 2007Date of Patent: November 9, 2010Assignee: Pfizer IncInventors: Mary T. Didiuk, Kevin K. Liu, David A. Griffith, Angel Guzman-Perez, Feng C. Bi, Daniel P. Walker
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Patent number: 7825254Abstract: The invention pertains to heteroaromatic compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE10. The invention also relates to intermediates for preparation of said compounds; pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.Type: GrantFiled: February 27, 2008Date of Patent: November 2, 2010Assignee: Pfizer Inc.Inventors: Patrick R. Verhoest, Christopher J. Helal, Dennis J. Hoover, John M. Humphrey
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Patent number: 7816362Abstract: Novel piperazine derivatives are provided having the formula wherein R1 is cyano, nitro, trifluoromethyl or halogen, or pharmaceutically acceptable acid addition salts thereof, which are useful as 5-HT1A receptor antagonists.Type: GrantFiled: May 5, 2009Date of Patent: October 19, 2010Assignee: Wyeth LLCInventors: Wayne Everett Childers, Michael Kelly, Sharon Joy Rosenzweig-Lipson
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Patent number: 7812040Abstract: This invention is directed to a compound of the formula Ia or Ib, as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro-iType: GrantFiled: June 12, 2006Date of Patent: October 12, 2010Assignee: Pfizer Inc.Inventor: Travis T Wager
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Patent number: 7812014Abstract: The present invention provides a compound of formula I wherein one of A and B is hydrogen and the other an optionally substituted fused bicyclic heteroaryl group as defined herein; X is O; R5 is H, C1-C6 alkyl, C5-C6 cycloalkyl, or CHR3OCOC1-C6 alkyl; and R3 is hydrogen, C1-C6 alkyl, C5-C6 cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.Type: GrantFiled: August 21, 2008Date of Patent: October 12, 2010Assignee: Wyeth LLCInventors: Aranapakam Mudumbai Venkatesan, Tarek Suhayl Mansour, Takao Abe, Itsuki Yamamura, Tsuyoshi Takasaki, Atul Agarwal, Osvaldo Dos Santos, Fuk-Wah Sum, Yang-I Lin
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Patent number: 7807838Abstract: The present invention relates to methods and compounds useful in the preparation of compounds of the formula (I).Type: GrantFiled: August 16, 2006Date of Patent: October 5, 2010Assignee: Pfizer Inc.Inventors: Christopher Frederick Matthews, Robert William Scott, John Lloyd Tucker
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Patent number: 7803827Abstract: The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1.5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia.Type: GrantFiled: November 6, 2008Date of Patent: September 28, 2010Assignee: Wyeth LLCInventors: John Michael Janusz, Stephen Joseph Hodson, Gregory Kent Bosch, Ronald Eugene White, Benjamin E. Blass, Christopher M. Jackson, Neil T. Fairweather
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Patent number: 7803808Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present invention provides for the use of 17-desmethylrapamycin and analogues thereof in the induction or maintenance of immunosuppression, the stimulation of neuronal regeneration or the treatment of cancer, B-cell malignancies, fungal infections, transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation vascular disease and fibrotic diseases, and in the regulation of wound healing.Type: GrantFiled: August 11, 2005Date of Patent: September 28, 2010Assignee: Wyeth LLCInventors: Matthew Alan Gregory, Christine Janet Martin
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Patent number: 7795243Abstract: Orally bioavailable prodrugs of sulopenem, e.g., and solvates and hydrates thereof, preparation thereof, formulation thereof, and use to treat and prevent infection in mammals such as humans. This abstract is not limiting to the invention.Type: GrantFiled: June 28, 2007Date of Patent: September 14, 2010Assignee: Pfizer, Inc.Inventors: Katherine E. Brighty, Anthony Marfat, Dale G. McLeod, John P. O'Donnell
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Patent number: 7795252Abstract: The present invention provides for methods of treating neurological disorders or complications due to stroke or head injury; benign or malignant neoplastic disease, carcinomas and adenocarcinomas; proliferative disorders; and inflammatory disorders using compounds of the following structure: The compounds are therefore useful as neuroprotective and neuroregenerative, anti-proliferative, and anti-inflammatory agents.Type: GrantFiled: June 9, 2009Date of Patent: September 14, 2010Assignee: Pfizer Inc.Inventors: Edmund Idris Graziani, Kevin Pong, Jerauld S. Skotnicki
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Patent number: 7795244Abstract: Orally bioavailable prodrugs of sulopenem, e.g., and solvates and hydrates thereof, preparation thereof, formulation thereof, and use to treat and prevent infection in mammals such as humans. This abstract is not limiting to the invention.Type: GrantFiled: June 30, 2008Date of Patent: September 14, 2010Assignee: Pfizer Inc.Inventors: Katherine Elizabeth Brighty, Anthony Marfat, Dale M. McLeod, John P. O'Donnell
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Patent number: 7795271Abstract: Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.Type: GrantFiled: May 4, 2009Date of Patent: September 14, 2010Assignee: Pharmacia CorporationInventor: Richard C. Durley
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Patent number: 7790197Abstract: A wet granulated pharmaceutical composition comprising atorvastatin or a pharmaceutically acceptable salt thereof with less than about 5 weight % of an alkaline earth metal salt additive with a disintegrant which provides the atorvastatin with not more than about 3% atorvastatin lactone based on the ratio of lactone peak area compared to the total drug-related peak integrated areas, as well as said wet granulated pharmaceutical composition comprising atorvastatin or a pharmaceutically acceptable salt thereof in combination with at least one other active drug, methods for preparing said compositions, kits for containing such compositions, and a method of treating hypercholesterolemia and/or hyperlipidemia, osteoporosis, benign prostatic hyperplasia (BPH), and Alzheimer's disease using a therapeutically effective amount of the pharmaceutical compositions.Type: GrantFiled: April 20, 2004Date of Patent: September 7, 2010Assignee: Warner-Lambert Company LLCInventors: Michael B. Fergione, Barbara A. Johnson, Kenneth Craig Waterman
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Patent number: 7790751Abstract: The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.Type: GrantFiled: August 14, 2006Date of Patent: September 7, 2010Assignee: Wyeth LLCInventors: Hassan Mahmoud Elokdah, Alexander Alexei Greenfield, Kevin Liu, Geraldine Ruth McFarlane, Cristina Grosanu, Jennifer Rebecca Lo, Albert Jean Robichaud
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Patent number: 7790740Abstract: The present invention provides compounds of formula (I) wherein R1 and R2 are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases and conditions, and in the treatment of infection by HIV and genetically related retroviruses.Type: GrantFiled: August 27, 2007Date of Patent: September 7, 2010Assignee: Pfizer IncInventor: Paul Anthony Stupple
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Patent number: 7790744Abstract: Provided are compounds of the formula (1): wherein R? is hydrogen, methyl or NH2C(O)CH2—; R? and R?? are independently methyl or hydrogen; R adn Ry are independently hydroxy or hydrogen; R1 is hydroxy, hydrogen, or hydroxysulfonyloxy; R7 is hydroxy, hydrogen, hydroxysulfonyloxy or phosphonooxy; R2 is a novel acyl side chain. Also provided are novel formulations, methods of inhibiting fungal and parasitic activity, and a process for preparing dideoxy (R?H) forms of the compounds.Type: GrantFiled: March 10, 2005Date of Patent: September 7, 2010Assignee: Eli Lilly and CompanyInventors: Frederick J. Burkhardt, Manuel Debono, Jeffrey S. Nissen, William Wilson Turner, Jr.
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Patent number: 7781428Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R1, R2, R3A, R3B, R4, R5, R6, R7, R8, and X are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, and intermediates are also disclosed.Type: GrantFiled: October 24, 2007Date of Patent: August 24, 2010Assignee: Pfizer Inc.Inventors: Marvin J. Meyers, Graciela B. Arhancet, Xiangyang Chen, Susan Hockerman, David B. Reitz, Joseph G. Rico
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Patent number: 7776885Abstract: This invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds for the manufacture of medicament for gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes and apnea syndrome. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.Type: GrantFiled: September 2, 2004Date of Patent: August 17, 2010Assignee: Pfizer, Inc.Inventors: Yasuhiro Katsu, Satoru Iguchi, Hiroki Sone, Chikara Uchida, Takashi Kojima