Abstract: An injectable slow-release naltrexone formulation is provided comprising naltrexone in a poly(D,L-lactide) matrix with a small amount of residual ethyl acetate. Upon intramuscular injection of the composition, naltrexone is released in a controlled manner over an extended period of time. The composition finds use in the treatment of heroin addicts and alcoholics to reduce consumption of the abused substances.
Type:
Grant
Filed:
April 7, 2000
Date of Patent:
October 23, 2001
Assignee:
Southern Research Institute
Inventors:
Thomas R. Tice, Jay K. Staas, Teresa M. Ferrell