Patents Represented by Attorney Jenny J. Yeh
  • Patent number: 8350013
    Abstract: The invention relates to methods for isolating a product and/or reducing turbidity and/or impurities from a load fluid comprising the product and one or more impurities by passing the load fluid through a medium, followed by at least one wash solution comprising arginine, and collecting the product using an elution solution. The invention further relates to a product prepared using a method as described herein.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: January 8, 2013
    Assignee: Wyeth LLC
    Inventor: Shujun Sun
  • Patent number: 8338576
    Abstract: The present invention provides antibodies and fragments thereof that bind to Dkk-1 and, in particular, to humanized antibodies and fragments thereof that bind to Dkk-1 and, even more particularly to fully humanized antibodies and immunologically functional fragments that bind to Dkk-1. Also provided are antibodies and fragments thereof which compete with the binding of an anti-mouse Dkk-1 monoclonal antibody for binding to Dkk-1+ cells. Also provided are nucleic acids encoding anti-Dkk-1 antibodies or fragments thereof, as well as expression vectors and host cells incorporating these nucleic acids for the recombinant expression of anti-Dkk-1 antibodies and fragments thereof. Also provided are methods of preparing the antibodies and fragments thereof of the invention. Also provided are bone anabolic agents. Pharmaceutical compositions comprising the antibodies or fragments thereof of the invention are also provided.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: December 25, 2012
    Assignees: Rinat Neuroscience Corp., Pfizer Inc.
    Inventors: Vishwas Madhav Paralkar, Donna Marie Stone, Mei Li, Jaume Pons