Patents Represented by Attorney Jerome Rosenstock
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Patent number: 6401724Abstract: A method of applying a cosmetic nail lacquer or polish to a nail of an animal is disclosed. The method comprises applying a polyurea composition to the nail. Such nail composition is selected from a reaction solution, a stabilized reaction solution, a blocked reaction solution or a mixture of any of the foregoing solution.Type: GrantFiled: October 10, 2000Date of Patent: June 11, 2002Assignee: Par Pharmaceuticals IncorporatedInventor: Kenneth I. Sawyer
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Patent number: 5770388Abstract: Methods are disclosed for separating a component of interest from a mixture containing the component of interest and other components. The method comprises contacting a first liquid medium containing the component of interest and other components with a second liquid medium that is of different density than and/or of different viscosity than the first liquid medium. The contact is carried out in such a way that mixing of the media is minimized or avoided. The component of interest is bound to magnetic particles. The contacted first liquid medium and second liquid medium are subjected to a magnetic field gradient to allow the magnetic particles to migrate into the second liquid medium and separation of the component of interest from other components is realized. Also disclosed are assays employing the present method. Kits for carrying out the present method and assays are also disclosed.Type: GrantFiled: December 13, 1993Date of Patent: June 23, 1998Assignee: Dade Behring Marburg GmbHInventor: John Vorpahl
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Patent number: 5766874Abstract: A D-arabinitol dehydrogenase enzyme is prepared that is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol and is substantially free of other enzymes capable of oxidizing D-mannitol. The enzyme is preferably obtained from Candida tropicalis ATCC 750 or Candida shehatae. The enzyme may also be obtained by recombinant DNA technology. Monoclonal antibodies are produced against the enzyme and can be used to identify the enzyme. The enzyme is used for detecting the presence of Candida in a host such as detecting Candida infection in a patient by determining the presence of D-arabinitol in a sample. The oxidation of D-arabinitol by nicotinamide adenine dinucleotide (NAD.sup.+) is catalyzed by the enzyme and the amount of NADH produced in a given time is determined. Also prepared is a composition containing the enzyme and NAD.sup.+ and a kit containing a packaged combination of the enzyme and NAD.sup.+.Type: GrantFiled: June 7, 1995Date of Patent: June 16, 1998Assignee: Syntex (USA) Inc.Inventors: Charles Garrett Miyada, Arthur C. Switchenko, Melanie W. Quong, Man-Ying Laurie Wong
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Patent number: 5696274Abstract: The present invention provides processes which are flexible, cost effective, and commercially viable methods of manufacturing or producing products from 2-hydroxyacetophenone (2-HAP).Of particular interest of the available products are 4-hydroxycoumarin, warfarin-alkali salt, preferably warfarin sodium and warfarin-alkali salt-isopropyl alcohol (2-propanol) complex, more preferably warfarin-sodium-isopropyl alcohol complex.As is known, these compounds are useful as vitamin K dependent anticoagulants in the treatment of humans and animals. In different doses, they are also useful as rodenticide.The inventive process involves contacting 2-HAP, carbonate ester and effective base followed by treatment with an unsaturated ketone and phase transfer catalyst to ultimately yield product.Type: GrantFiled: May 22, 1996Date of Patent: December 9, 1997Assignee: Hoechst Celanese CorporationInventors: Ibrahim M. Uwaydah, Mohammad Aslam, Charles H. Brown, II, Sharon R. Fitzhenry, Joseph A. McDonough
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Patent number: 5330986Abstract: This invention relates to indole-7-carboxamide derivatives of the formula ##STR1## where R.sub.1 through R.sub.6 are independently H, loweralkyl, aryl, and aralkyl; and in addition R.sub.3 and R.sub.5 can be joined together to form a piperazine ring of the formula ##STR2## where R.sub.7 is H, loweralkyl, aryl, arylloweralkyl, pyrimidyl; and R.sub.4 and R.sub.5 can be joined together to form a pyrrolidine ring of the formula ##STR3## where R.sub.8 is H, loweralkyl, aryl, arylloweralkyl; X is H, loweralkyl, halogen, NO.sub.2, CF.sub.3, NH.sub.2, and OR.sub.9 ; where R.sub.9 is loweralkyl, arylloweralkyl and n is an integer of 1 to 3; and the pharmaceutically acceptable acid addition salts thereof and the optical isomers thereof where such isomers exist.Type: GrantFiled: November 24, 1992Date of Patent: July 19, 1994Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventor: Gregory M. Shutske
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Patent number: 5241098Abstract: The present invention pertains to a method of forming a salt of 4-hydroxystyrene by reacting 4-acetoxystyrene with a suitable base in a suitable solvent system. Subsequently, or simultaneously, the salt of 4-hydroxystyrene can be reacted, preferably in situ, with di-tertiary-butyl-dicarbonate to form 4-tertiary-butoxycarbonyloxystyrene.Type: GrantFiled: November 16, 1990Date of Patent: August 31, 1993Assignee: Hoechst Celanese CorporationInventors: George Kvakovszky, James H. Rea, Michael T. Sheehan, Brad L. Smith
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Patent number: 5215984Abstract: This invention relates to spiro-](piperidine-, pyrrolidine-, or -hexahydroazepinyl substituted) pyrrolo[2,1-c][1,4]-benzoxazepines] having the following formula ##STR1## wherein R is hydrogen, lower alkyl, arylloweralkyl, acyl, lower alkenyl, lower alkynyl, and loweralkylbenzisoxazole; X is hydrogen, halogen, loweralkoxy, and trifluoromethyl; Y is hydrogen; 2' or 3' acyl, formyl, carbinol of the formula ##STR2## where R.sub.1 and R.sub.2 are the same or different and are independently hydrogen, loweralkyl, arylloweralkyl, aryl, loweralkenyl, lower alkynyl and lower alkylbenzisoxazole; loweralkyl, loweralkenyl and halogen; and n is an integer of 1 to 3. The compounds of this invention display utility as analgesic and antihypertensive agents.Type: GrantFiled: November 24, 1989Date of Patent: June 1, 1993Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Richard C. Effland, Larry Davis, Kevin J. Kapples
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Patent number: 5087772Abstract: A method for preparing 4-hydroxystyrene is disclosed. The method comprises reacting 4-acetoxystyrene with a suitable alcohol in the presence of a catalytic amount of a suitable base.Type: GrantFiled: November 16, 1990Date of Patent: February 11, 1992Assignee: Hoechst Celanese CorporationInventors: Michael T. Sheehan, Lan Shen
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Patent number: 5041614Abstract: A method for the preparation of 4-acetoxystyrene is disclosed. The method comprises heating 4'-acetoxyphenylmethylcarbinol in the presence of a suitable acid anhydride and a suitable dehydration catalyst in a continuous feed reaction mode to make the 4-acetoxystyrene.Type: GrantFiled: July 3, 1990Date of Patent: August 20, 1991Assignee: Hoechst Celanese CorporationInventors: Mohammad Aslam, Charles B. Hilton
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Aminoglycoside composition having substantially reduced nephrotoxicity induced by the aminoglycoside
Patent number: 5039666Abstract: This invention relates to an aminoglycoside composition having reduced nephrotoxicity induced by the aminoglycoside which comprises a selected aminoglycoside and a compound present in an effective amount selected from the group consisting of (a) at least one 7-(oxoalkyl)1,3-dialkyl xanthine of the formula ##STR1## in which R.sub.1 and R.sub.2 are the same or different and are independently selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, straight-chain or branched chain alkoxyalkyl and hydroxyalkyl radicals; and A is a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group; (b) a compound of the formula ##STR2## wherein at least one of R.sub.3 and R.sub.4 is a branched hydroxyalkyl group of the formula ##STR3## with a tertiary alcohol function, which R.sub.6 stands for an alkyl group with 1 to 3 carbon atoms and n stands for a whole number from 2 to 5, the other R.sub.3 or R.sub.Type: GrantFiled: October 30, 1990Date of Patent: August 13, 1991Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventor: William J. Novick, Jr. -
Patent number: 5017578Abstract: This invention relates to a N-heteroaryl-purin-6-amine of the formula ##STR1## where R.sub.1 is hydrogen, lower alkyl, and arylloweralkyl; R.sub.2 and R.sub.3 are independently hydrogen, lower alkyl or R.sub.2 and R.sub.3 taken together are aryl; R.sub.4 and R.sub.5 are independently hydrogen, lower alkyl, or R.sub.4 and R.sub.5 taken together are aryl; R.sub.6 is hydrogen, lower alkyl, aryl, arylloweralkyl, ##STR2## where R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined above, and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic and anticonvulsant agents.Type: GrantFiled: June 9, 1989Date of Patent: May 21, 1991Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Richard C. Effland, Joseph T. Klein, Larry Davis, Gordon E. Olson
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Patent number: 4999356Abstract: Novel 1-phenyl-3-(1-piperazinyl)-1H-indazoles, intermediates and processes for the preparation thereof, and methods for alleviating pain, treating convulsions, and treating depression utilizing compounds or compositions thereof are disclosed.Type: GrantFiled: December 23, 1988Date of Patent: March 12, 1991Assignee: Hoechst-Roussel Pharmaceuticals, Inc.Inventor: Joseph T. Strupczewski
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Patent number: 4988690Abstract: The invention relates to 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines of the formula ##STR1## wherein Y is the same or different and is hydrogen and lower alkoxy; X is hydrogen, halogen, lower alkyl, lower alkoxy, CF.sub.3, NO.sub.2, CN and NH.sub.2 ; R is hydrogen, lower alkyl, cycloalkyllower alkyl, ##STR2## Ar lower alkyl of the formula -alkylene ##STR3## where Z is hydrogen, lower alkyl, lower alkoxy, halogen, CF.sub.3, NO.sub.2 and NH.sub.2 ; and an alkylene amine of the formula ##STR4## where R.sub.1 and R.sub.2 are the same of different and are hydrogen and lower alkyl, and the pharmaceutically acceptable acid addition salts thereof.Type: GrantFiled: June 14, 1982Date of Patent: January 29, 1991Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Richard C. Effland, Joseph T. Klein, Larry Davis
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Patent number: 4971992Abstract: This invention relates to 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol carbonate esters of the ##STR1## the pharmaceutically acceptable acid addition salts thereof and where applicable to the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic agents.Type: GrantFiled: March 27, 1989Date of Patent: November 20, 1990Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Edward J. Glamkowski, Yulin Chiang, Barbara E. Kurys
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Patent number: 4960767Abstract: This invention relates to isoxazolobenzoxazepines having the following formula ##STR1## wherein X.sub.1 is H; X.sub.2 is H or OH; or X.sub.1 and X.sub.2 taken together are carbonyl oxygen or ##STR2## R is (1) H, (2) loweralkyl, (3) arylloweralkyl, (4) loweralkynyl, (5) loweralkenyl, (6) ##STR3## where R.sub.1 and R.sub.2 are independently (a) H, (b) lower alkyl, (c) arylloweralkyl, (d) ##STR4## where Z is H, halogen, loweralkyl, loweralkoxy, CF.sub.3, nitro or amino and n' is an integer of 1 to 3; (e) ##STR5## where n" is an integer of 1 to 3; or (f) R.sub.1 and R.sub.2 taken together with the nitrogen atom are substituted or unsubstituted piperidino or pyrrolidino of the formula ##STR6## where R.sub.3 is H, loweralkyl or aryl, and m is an integer of 1 or 2; (7) ##STR7## where R.sub.4 is H or loweralkyl and m' is an integer of 3 or 4; (8) ##STR8## where Z and n' are as previously defined; (9) ##STR9## where m'" is an integer of 1, 2, or 3 (10) ##STR10## where R.sub.5 and R.sub.Type: GrantFiled: January 30, 1989Date of Patent: October 2, 1990Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Gregory M. Shutske, Kevin J. Kapples
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Patent number: 4954503Abstract: This invention relates to 3-(1-substituted-4-piperazinyl)-1H-indazoles having the following formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, arylloweralkyl, acyl, cycloalkylloweralkylene, and phenylsulfonyl: and R.sub.2 is hydrogen, lower alkyl, hydroxyloweralkyl of the formula ##STR2## where Z is selected from hydrogen, halogen, loweralkoxy, CF.sub.3, NO.sub.2, and NH.sub.2 ; ##STR3## where Z is as defined above; ##STR4## where Z is as defined above; ##STR5## where R.sub.3 and R.sub.4 are each independently hydrogen and loweralkyl; ##STR6## where Z is as defined above; ##STR7## where R' and R" are each independently hydrogen and loweralkyl; X is hydrogen, loweralkyl, hydroxyl, halogen, loweralkoxy, CF.sub.3, NO.sub.2 and amino; n is an integer of 1 to 4, with the further proviso that R.sub.2 is not loweralkyl when R.sub.Type: GrantFiled: September 11, 1989Date of Patent: September 4, 1990Assignee: Hoechst-Roussel Pharmaceuticals, Inc.Inventors: Joseph T. Strupczewski, Kenneth J. Bordeau
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Patent number: 4908360Abstract: This invention relates to 1-aminoalkyl-3-oxysubstituted-4-aryl-1,3,4,5-tetrahydro-2H-1,3-benzodiazep ine-2-ones having the formula ##STR1## where R.sub.1 and R.sub.2 are each independently hydrogen, loweralkyl, aryl, arylloweralkyl, and acyl; R.sub.3 is hydrogen, loweralkyl, arylloweralkyl aryl and acyl; X is hydrogen, halogen, hydroxy loweralkyl, loweralkoxy, NO.sub.2, NH.sub.2 and CF.sub.3 ; m is an integer of 1 to 3, n is an integer of 1 to 3; the pharmaceutically acceptable acid addition salts thereof and where appropriate the geometric and optical isomers thereof. The compounds of this invention display utility as analgesics, calcium ion antagonists and antihypertensives.Type: GrantFiled: November 14, 1988Date of Patent: March 13, 1990Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Lawrence L. Martin, Joseph F. Payack
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Patent number: 4894461Abstract: 3-(.gamma.-chloropropyl)-6-fluoro-1,2-benzisoxazole is a compound useful in preparing compounds having a neuroleptic utility.Type: GrantFiled: February 27, 1986Date of Patent: January 16, 1990Assignee: Hoechst-Roussel Pharmaceuticals, Inc.Inventors: Larry Davis, Richard C. Effland
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Patent number: 4873234Abstract: This invention relates to isoxazolobenzoxazepines having the following formula ##STR1## wherein X.sub.1 is H; X.sub.2 is H or OH; or X.sub.1 and X.sub.2 taken together are carbonyl oxygen or ##STR2## R is (1) H, (2) loweralkyl, (3) arylloweralkyl, (4) loweralkynyl, (5) loweralkenyl, ##STR3## where R.sub.1 and R.sub.2 are independently (a) H, (b) lower alkyl, (c) arylloweralkyl, (d) lower alkylene ##STR4## where Z is H, halogen, loweralkyl, loweralkoxy, CF.sub.3, nitro or amino and n is a integer of 1 to 3; ##STR5## where n" is an integer of 1 to 3; or (f) R.sub.1 and R.sub.2 taken together with the nitrogen atom are substituted or unsubstituted piperidino or pyrrolidino of the formula ##STR6## where R.sub.3 is H, loweralkyl or aryl, and m is an integer of 1 to 2; ##STR7## wherein R.sub.4 is H or loweralkyl and m' is an integer of 3 to 4; ##STR8## where Z and n are as previously defined; ##STR9## where m'" is an integer of 1,2 or 3 ##STR10## where R.sub.5 and R.sub.Type: GrantFiled: August 1, 1988Date of Patent: October 10, 1989Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Gregory M. Shutske, Kevin J. Kapples
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Patent number: RE39682Abstract: Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: wherein R1represents farnesyl, geranyl or geranyl-geranyl; Z represents C—R6 or N; R2 represents H, CN, the groups COOR7, SO3R7, CONR7R8 and SO2NR7R7, wherein R7 and R8 are each independently hydrogen, alkyl, alkenyl, and the groups COOM and SO3M, wherein M is a cation; R3, R4, R5 and R6 are each independently hydrogen, carboxyl, alkyl, alkenyl, aminoalkyl, nitroalkyl, nitro, halo, amino, mono- or di-alkylamino, mercapto, mercaptoalkyl, azido, or thiocyanato; X represents O, S, SO, SO2, NH or Se; and the quaternary ammonium salts and N-oxides of the compounds of formula I wherein Z is N.Type: GrantFiled: March 30, 2005Date of Patent: June 5, 2007Assignee: Ramot at Tel Aviv University Ltd.Inventor: Yoel Kloog