Patents Represented by Attorney, Agent or Law Firm Jerrie L. Chiu
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Patent number: 6677352Abstract: The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,6-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.Type: GrantFiled: September 23, 2002Date of Patent: January 13, 2004Inventors: Yamin Wang, William H. Bullock, Libing Chen
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Patent number: 6586613Abstract: Substituted tetrahydro-naphthalenes and analogous compounds are prepared by reducing or condensing appropriate functional substituents in substituted tetrahydro-naphthalenes and analogous compounds by customary methods and converting functional groups in this manner into the desired groups. The compounds according to the invention are suitable for use as active compounds in pharmaceuticals, in particular in pharmaceuticals for treating arteriosclerosis and also dyslipidaemias.Type: GrantFiled: March 17, 2000Date of Patent: July 1, 2003Assignee: Bayer AktiengellschaftInventors: Arndt Brandes, Michael Lögers, Jürgen Stoltefuss, Gunter Schmidt, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt, Stefan Antons, Holger Paulsen, Stephan Nicholas Müller, Paul Naab, Carsten Schmeck
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Patent number: 6573263Abstract: The present invention relates to new substituted imidazotriazinones, processes for their preparation, and their use for the production of medicaments, in particular for improving perception, concentration power, learning power and/or memory power.Type: GrantFiled: December 21, 2001Date of Patent: June 3, 2003Assignee: Bayer AktiengesellschaftInventors: Ulrich Niewöhner, Dagmar Schauss, Martin Hendrix, Gerhard König, Frank-Gerhard Böss, Franz-Josef Van Der Staay, Rudy Schreiber, Karl-Heinz Schlemmer, Rolf Grosser
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Patent number: 6566360Abstract: The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.Type: GrantFiled: August 30, 2001Date of Patent: May 20, 2003Assignee: Bayer AktiengesellschaftInventors: Ulrich Niewöhner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Karl-Heinz Schlemmer, Jörg Keldenich, Erwin Bischoff, Elisabeth Perzborn, Klaus Dembowsky, Peter Serno, Marc Nowakowski
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Patent number: 6562811Abstract: Pyridine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C1-6 alkylsulfonylamino, C1-6 alkoxycarbonyl, C1-6 alkylamino, di(C1-6 alkyl)amino, C1-6 alkanoylamino, phenyl C1-6 alkylamino, phenylsulfonylamino, or —O—(CH2)n—R111; R2 represents hydrogen or halogen; R3 represents hydrogen, —CR31R32R33, or —NR34R35; R4 is hydrogen, carbamoyl, CN, carboxyl, etc.; R5 is amino, C1-6 alkylamino, di C1-6 alkylamino, etc. or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.Type: GrantFiled: September 18, 2001Date of Patent: May 13, 2003Assignee: Bayer AktiengesellschaftInventors: Toshiki Murata, Masaomi Umeda, Sachiko Sakakibara, Takashi Yoshino, Hiroki Sato, Tsutomu Masuda, Yuji Koriyama, Mitsuyuki Shimada, Takuya Shintani, Hiroshi Kadono, Timothy B. Lowinger, Karl B. Ziegelbauer, Kinji Fuchikami, Hiroshi Komura
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Patent number: 6555580Abstract: The invention relates to novel amino- and amido-diphenyl ethers, processes for their preparation and their use in pharmaceuticals, in particular for the indications of arteriosclerosis and hypercholesterolaemia.Type: GrantFiled: July 31, 2001Date of Patent: April 29, 2003Assignee: Bayer AktiengesellschaftInventors: Helmut Haning, Josef Pernerstorfer, Gunter Schmidt, Michael Woltering, Hilmar Bischoff, Verena Vöhringer, Axel Kretschmer, Christiane Faeste
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Patent number: 6548079Abstract: The present invention relates to an aqueous formulation comprising moxifloxacin hydrochloride and sodium chloride, to the formulation for use as a medicament and to the use of the formulation for preparing a medicament for preventing or treating bacterial infections in humans or animals.Type: GrantFiled: February 5, 2002Date of Patent: April 15, 2003Assignee: Bayer AktiengesellschaftInventors: Bernd Kühn, Hans-Friedrich Mahler, Michael Eisele
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Patent number: 6545029Abstract: The present invention relates to new phenylserine derivatives as integrin antagonists with a broad spectrum of action having, inter alia, antiosteoporotic, antirestenotic, anticarcinogenic and antiatherosclerotic activity. The present invention moreover relates to the preparation of these compounds and their use for the production of medicaments, and also medicaments comprising them.Type: GrantFiled: June 12, 2001Date of Patent: April 8, 2003Assignee: Bayer AktiengesellschaftInventor: Andrea Vaupel
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Patent number: 6521707Abstract: The invention relates to novel isocyanates containing tertiary amino groups, a process for preparing them, and also their use for the synthesis and modification of polymers. The invention provides isocyanates of the formula (I) where R1 and R2 are, independently of one another, alkyl having from 1 to 6 carbon atoms, where R1 and R2 may be joined to form a ring, Z is alkylene having from 2 to 6 carbon atoms, n is an integer from 0 to 20, Y is alkylene having from 2 to 6 carbon atoms. The alkyl radicals R1 and R2 may be linear or branched or joined to form an aliphatic ring. The alkylene radical Z preferably contains from 2 to 4 carbon atoms.Type: GrantFiled: November 1, 2001Date of Patent: February 18, 2003Assignee: Bayer AktiengesellschaftInventors: Wolfgang Podszun, Joachim Krüger, Kamelia Karlou-Eyrisch
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Patent number: 6506734Abstract: The present invention relates to glycoconjugates of 20(S)-camptothecin, in which a 3-O-methylated &bgr;-L-fucose unit is linked to the 20-hydroxyl group of a camptothecin derivative via a thiourea-modified peptide spacer. The invention furthermore relates to processes for the preparation of the compounds according to the invention and to their use as medicaments, in particular in connection with oncoses.Type: GrantFiled: October 27, 1999Date of Patent: January 14, 2003Assignee: Bayer AktiengesellschaftInventors: Hans-Georg Lerchen, Karsten von dem Bruch, Jörg Baumgarten, Michael Sperzel
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Patent number: 6503913Abstract: The invention relates to new 2-heterocyclically substituted dihydropyrimidines, medicaments which contain these 2-heterocyclically substituted dihydropyrimidines, and a process for preparation of medicaments. The invention furthermore relates to the use of the 2-heterocyclically substituted dihydropyrimidines for the production of a medicament, in particular for the treatment of acute or chronic viral diseases, in particular for the production of a medicament for the treatment of acute or chronic hepatitis B infections.Type: GrantFiled: October 18, 2000Date of Patent: January 7, 2003Assignee: Bayer AktiengesellschaftInventors: Siegfried Goldmann, Jürgen Stoltefuss, Arnold Paessens, Erwin Graef, Stefan Lottmann
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Patent number: 6500817Abstract: The present invention relates to thiazolylurea derivatives, a process for their preparation, and their use as pharmaceuticals, in particular as antiviral pharmaceuticals.Type: GrantFiled: August 31, 2001Date of Patent: December 31, 2002Assignee: Bayer AktiengesellschaftInventors: Rüdiger Fischer, Gerald Kleymann, Judith Baumeister, Wolfgang Bender, Ulrich Betz, Peter Eckenberg, Gabriele Handke, Martin Hendrix, Udo Schneider, Olaf Weber, Kerstin Henninger, Axel Jensen, Jörg Keldenich
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Patent number: 6498183Abstract: The present invention relates to novel compounds which are suitable as pharmaceuticals, to processes for their preparation and to their use as pharmaceuticals, in particular as antiviral agents.Type: GrantFiled: February 27, 2002Date of Patent: December 24, 2002Assignee: Bayer AktiengesellschaftInventors: Wolfgang Bender, Peter Eckenberg, Siegfried Goldmann, Michael Härter, Sabine Hallenberger, Jürgen Reefschläger, Jörg Trappe, Olaf Weber
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Patent number: 6495545Abstract: The present invention relates to compounds of general formula (I) and their preparation and use for the production of pharmaceuticals, and pharmaceuticals comprising these compounds.Type: GrantFiled: June 12, 2001Date of Patent: December 17, 2002Assignee: Bayer AktiengesellschaftInventors: Klaus Urbahns, Delf Schmidt, Ulf Brüggemeier, Christoph Gerdes, Beatrix Stelte-Ludwig, Jörg Keldenich, Elke Stahl
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Patent number: 6476029Abstract: The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.Type: GrantFiled: March 23, 2001Date of Patent: November 5, 2002Assignee: Bayer AktiengesellschaftInventors: Ulrich Niewöhner, Mazen Es-Sayed, Helmut Haning, Thomas Schenke, Gunter Schmidt, Karl-Heinz Schlemmer, Erwin Bischoff, Klaus Dembowsky, Elisabeth Perzborn
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Patent number: 6469054Abstract: The present invention relates to novel arylsulphonamides and analogues, to processes for their preparation and to their use for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy, craniocerebral trauma, pain and spasticity.Type: GrantFiled: February 16, 2001Date of Patent: October 22, 2002Assignee: Bayer AktiengesellshaftInventors: Joachim Mittendorf, Jürgen Dressel, Michael Matzke, Jörg Keldenich, Frank Mauler, Jean-Marie-Victor de Vry, Jürgen Franz, Peter Spreyer, Verena Vöhringer, Joachim Schumacher, Michael-Harold Rock, Ervin Horvàth, Arno Friedl, Klaus-Helmut Mohrs, Siegfried Raddatz, Reinhard Jork
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Patent number: 6462074Abstract: The present invention relates to novel substituted (&agr;,&bgr;-fused butyrolactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cerebral ischaemias, craniocerebral trauma, states of pain or CNS-mediated spasms.Type: GrantFiled: July 14, 2000Date of Patent: October 8, 2002Assignee: Bayer AktiengesellschaftInventors: Andreas Stolle, Horst-Peter Antonicek, Stephen Lensky, Arnd Voerste, Thomas Müller, Jörg Baumgarten, Karsten von dem Bruch, Gerhard Müller, Udo Stropp, Ervin Horváth, Jean-Marie-Viktor de Vry, Rudy Schreiber
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Patent number: 6458796Abstract: The present invention relates to novel dihydro-[1,2,3]triazolo-[4,5-d]pyrimidin-7-one, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.Type: GrantFiled: February 26, 2001Date of Patent: October 1, 2002Assignee: Bayer AktiengesellschaftInventors: Helmut Haning, Ulrich Niewöhner, Ulrich Rosentreter, Thomas Schenke, Erwin Bischoff, Karl-Heinz Schlemmer
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Patent number: 6436943Abstract: The invention relates to dihydropyrimidines of the general formula and to the use of dihydropyrimidines as medicaments for the treatment and prophylaxis of hepatitis B. The invention further relates to a process for the preparation of medicaments comprising the corresponding dihydropyrimidines.Type: GrantFiled: October 18, 2000Date of Patent: August 20, 2002Assignee: Bayer AktiengesellschaftInventors: Jürgen Stoltefuss, Siegfried Goldmann, Arnold Paessens, Erwin Graef, Stefan Lottmann
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Patent number: 6420393Abstract: The invention relates to cyclopentabenzofuran derivatives, processes for their preparation, the use of cyclopentabenzofuran derivatives for the production of a medicament for the therapy of NF-&kgr;B-dependent diseases and medicaments which contain the cyclopentabenzofuran derivatives.Type: GrantFiled: March 26, 2001Date of Patent: July 16, 2002Assignee: Bayer AktiengesellschaftInventors: Walter Guarnieri, Thomas Jaetsch, Andreas Schoop, Jörg Baumgarten, Axel Kretschmer, Horst-Peter Antonicek