Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.
Type:
Grant
Filed:
December 6, 2001
Date of Patent:
October 7, 2003
Assignee:
Affymetrix, Inc.
Inventors:
Lubert Stryer, Michael C. Pirrung, J. Leighton Read, Stephen P. A. Fodor