Patents Represented by Attorney Jian S. Zhou
  • Patent number: 7521519
    Abstract: The invention relates to novel crosslinkable copolymers of formula wherein the variables are as defined in the claims. The copolymers of the invention are especially useful for the manufacture of biomedical molding, for example ophthalmic moldings such as in particular contact lenses.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: April 21, 2009
    Assignee: Novartis AG
    Inventors: Thomas Hirt, Jacalyn Marie Schremmer, Troy Vernon Holland, Dieter Lohmann
  • Patent number: 7135521
    Abstract: The invention relates to ophthalmic molding formulations and to tinted, high Dk ophthalmic moldings. This invention also relates to a method for making a tinted ophthalmic molding. The method comprises: (a) providing a polymer precursor having cross-linkable or polymerizable groups; (b) providing a pigment dispersion comprising an inorganic or organic pigment and a dispersing agent; (c) mixing the pigment dispersion with the polymer precursor to form a tinted prepolymer mixture; (d) dispensing the tinted prepolymer mixture into a mold; and (e) forming a tinted ophthalmic molding from the tinted prepolymer mixture, the molding comprising a polymer matrix having the pigment entrapped therein. With this method, tinted ophthalmic moldings, particularly edge-to-edge soft, tinted contact lenses having improved properties, are prepared with an improved efficiency.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: November 14, 2006
    Assignee: Novartis AG
    Inventors: Richard Charles Turek, Jacalyn Mary Schremmer
  • Patent number: 7040756
    Abstract: The present invention generally relates to a method of modifying the surface of substrates such as contact lenses and other biomedical articles by at least partially coating the surfaces of such substrates with a polymeric tie layer having reactive sites. Various other moieties may then be chemically attached to the article surface by reaction of the other moieties with the reactive sites through classical chemical attachment mechanisms.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: May 9, 2006
    Assignee: Novartis AG
    Inventors: Yongxing Qiu, Lynn Cook Winterton, John Martin Lally
  • Patent number: 7036931
    Abstract: The present invention provides an ophthalmic lens capable of correcting or minimizing presbyopia, or of functioning used as an anti-myopic lens. The ophthalmic lens can be a contact lens, a phakic intraocular lens or an aphakic intraocular lens. The ophthalmic lens comprises an optical zone, the optical zone having a first surface and an opposite second surface and including a coma-like wavefront aberration oriented vertically from the top to the bottom of the ophthalmic lens. In addition, the present invention provides a method for minimizing/correcting presbyopia or for preventing children's eyes from becoming severely myopic.
    Type: Grant
    Filed: January 21, 2004
    Date of Patent: May 2, 2006
    Assignee: Novartis AG
    Inventors: Joseph Michael Lindacher, Courtney Flem Morgan
  • Patent number: 7022654
    Abstract: A composition for disinfecting a contact lens comprising an effective disinfecting amount of hydrogen peroxide and a surfactant comprising a copolymer of hydrophobe and hydrophile blocks the structure: HO-(hydrophobe)x-(hydrophile)y-(hydrophobe)x-H or HO-(hydrophile)y-(hydrophobe)x-(hydrophile)y-H where x and y are integers reflecting the respective hydrophile and hydrophobe blocks of said copolymer; and the hydrophile component of the block copolymer constitutes less than 50 weight percent of the block copolymer. The block copolymer has a Ross-Miles foam height (ASTM designation D-1173-53; 0.1%, at 50° C.) of less than 1 mm.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: April 4, 2006
    Assignee: Novartis AG
    Inventor: Fu-Pao Tsao
  • Patent number: 7022379
    Abstract: A method of forming a coating of polyionic materials in a layer-by-layer-like manner onto a polymeric material is provided. A polymeric material, such as a contact lens, can be dipped once into a solution of polyionic materials such that layers of polyionic material can be formed thereon. A single dip solution of the present invention typically contains a polyanionic material and a polycationic material in a non-stoichiometric amount and maintained within a certain pH range.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: April 4, 2006
    Assignee: Novartis AG
    Inventors: Lynn Cook Winterton, John Martin Lally, Michael Rubner, Yongxing Qiu
  • Patent number: 7011513
    Abstract: The present invention discloses an apparatus for cleaning ophthalmic devices. The apparatus has a conveying system for transporting lens mold carriers to a cleaning station. The cleaning station has at least one movable cleaning assembly which is situated above the lens mold carrier and has a recess. When the cleaning assembly is lowered to the lens mold carrier, a substantially enclosed or enclosed cavity containing the lens mold is created by the carrier and the recess of the cleaning assembly. Compressed gas is injected into the cavity to dislodge any debris that may be present on the lens molds, and a vacuum is employed to remove gas and debris from the cavity.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: March 14, 2006
    Assignee: Novartis AG
    Inventor: Todd Aldridge Russell
  • Patent number: 7011408
    Abstract: A method of making a colored contact lens comprises printing at least one layer of a colorant onto a contact lens using a printing process selected from the group consisting of ink jet printing, electrophotographic printing, thermal transfer printing, and photographic development printing. Printing can be done directly on the contact lens, on a film in a mold where the contact lens is formed, or on a cliché pad. Multiple layers of colorants can be printed onto a contact lens.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: March 14, 2006
    Assignee: Novartis AG
    Inventor: Robert Carey Tucker
  • Patent number: 7004585
    Abstract: An ophthalmic lens, such as multifocal contact lens, that is worn on the surface of the eye and has a blended design for a segmented optical zone. The lens has an anterior surface and an opposite posterior surface, wherein the anterior surface includes a vertical meridian, a horizontal meridian, a central optical zone having at least a first optical zone for primary gaze, a second optical zone for down-gaze and an optical blending zone between the first and second optical zones. The optical blending zone has a surface that ensures a smooth surface transition from the first optical zone to the second optical zone and that allows the first and second optical zone to be designed independently and optimally so that ghost images or blur from the transition between the first and second optical zones can be minimized or eliminated. Image blur from the blend zone that subtends the pupil is minimized by the magnitude of the curvature of the blend zone.
    Type: Grant
    Filed: January 28, 2004
    Date of Patent: February 28, 2006
    Assignee: Novartis AG
    Inventor: Joseph Michael Lindacher
  • Patent number: 6995192
    Abstract: The present invention provides a radiation-curable prepolymer. The radiation-curable prepolymer of the invention is prepared by reacting an isocyanate-capped polyurethane with an ethylenically unsaturated amine or an ethylenically unsaturated monohydroxy compound or a mixture thereof, wherein the isocyanate-capped polyurethane is a copolymerization production of: (a) at least one polyalkylene glycol; (b) at least one branching agent having at least three hydroxy groups; and (c) at least one di- or polyisocyanate. The radiation-curable prepolymer of the invention can find use in economically producing contact lenses which have durable, highly elastic soft contact lenses with desired physical properties. In addition, the present invention provides method for making a radiation-curable prepolymer of the invention and for making a medical device, preferably an ophthalmic device, more preferably a contact lens.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: February 7, 2006
    Assignee: Novartis AG
    Inventors: John Christopher Phelan, Michael Hugh Quinn, Joshua Andrew Wallach
  • Patent number: 6980842
    Abstract: An ophthalmic lens comprising a receptor moiety can be used to determine the amount of an analyte in an ocular fluid. The receptor moiety can bind either a specific analyte or a detectably labeled competitor moiety. The amount of detectably labeled competitor moiety which is displaced from the receptor moiety by the analyte is measured and provides a means of determining analyte concentration in an ocular fluid, such as tears, aqueous humor, or interstitial fluid. The concentration of the analyte in the ocular fluid, in turn, indicates the concentration of the analyte in a fluid or tissue sample of the body, such as blood or intracellular fluid.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: December 27, 2005
    Assignee: Novartis
    Inventors: Wayne Front March, Mary Flowers Mowery-McKee
  • Patent number: 6955832
    Abstract: The present invention provides novels inks and methods for making a colored polymeric substrates, preferably a contact lens. In the inventive method at least a portion of a surface of a lens is coated with a color coat comprising at least one colorant, and a binder polymer obtained by copolymerizing a first monomer being ethylenically unsaturated and having a latent crosslinkable pendent group; and a second monomer having an ethylenically unsaturated double bond copolymerizable with the first monomer. The lens is then subjected to conditions that cause the color coat to adhere to the lens.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: October 18, 2005
    Assignee: Novartis AG
    Inventors: Michael Hugh Quinn, Robert Carey Tucker, Sandra Corti, John Christopher Phelan
  • Patent number: 6942341
    Abstract: A method of producing a master cast used in making a contact lens mold, comprising the steps of: rotating a master cast blank, having an outer surface, about a first rotational axis and cutting at lest one first surface onto the outer surface of the master cast blank; and rotating the master cast blank about a plurality of secondary rotational axes, each secondary rotational axis being different from the first rotational axis, and cutting a portion of a ridge-off surface from the outer surface of the master cast blank while rotating at each secondary rotational axis.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: September 13, 2005
    Assignee: Novartis AG
    Inventors: Ming Ye, Xiaoxiao Zhang
  • Patent number: 6939511
    Abstract: A method and composition for disinfecting a contact lens is disclosed. The method includes treating a lens with an aqueous solution having reduced toxicity to the eye which contains an effective amount of a monoperphthalic acid compound in a concentration of less than about 0.5% by weight of the solution. The lens disinfecting solution is capable of disinfecting contact lenses without irritating the eye due to reduced toxicity of the composition.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: September 6, 2005
    Assignee: Novartis AG
    Inventor: Fu-Pao Tsao
  • Patent number: 6926965
    Abstract: The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.
    Type: Grant
    Filed: September 3, 2003
    Date of Patent: August 9, 2005
    Assignee: Novartis AG
    Inventors: Yongxing Qiu, Lynn Cook Winterton, John Martin Lally
  • Patent number: 6923978
    Abstract: The invention is directed to a composite material, especially a biomedical device, e.g. an ophthalmic device, preferably a contact lens, with one or more wettable surfaces capable of holding a continuous layer of aqueous fluid thereon which composite material comprises a bulk material and a hydrophilic coating characterized in that the hydrophilic coating consists of a carbohydrate attached covalently to reactive groups at the surface of the bulk material, either directly or via functional groups of an oligofunctional compound, said oligofunctional compound in turn having functional groups being capable of reacting with said reactive groups at the surface of the bulk material and with the carbohydrate, wherein said reactive groups are either inherently (a priori) present in the bulk material or wherein said reactive groups have been attached to the surface of the bulk material by a plasma surface preparation, as well as to a process of manufacture of such a composite material.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: August 2, 2005
    Assignee: Novartis AG
    Inventors: Ronald Christopher Chatelier, Liming Dai, Hans Jörg Griesser, Sheng Li, Paul Zientek, Dieter Lohmann, Peter Chabrecek
  • Patent number: 6878314
    Abstract: A method of automatic manufacture of an astigmatic contact lens having a toric portion and a ballast portion such that said ballast portion causes the toric portion of the contact lens to properly orient in the eye of the wearer. The toric lenses are manufactured by moving a pallet containing at least half of a casting cup assembly and an information tag under a filling assembly and filling half of a casting cup assembly with liquid monomer, then moving the pallet to a closing assembly and, based on information obtained from the information tag, rotating one or both halves of the casting cup assembly and closing the casting cup assembly. The liquid monomer is then cured thereby creating a toric contact lens.
    Type: Grant
    Filed: August 21, 2002
    Date of Patent: April 12, 2005
    Assignee: Novartis AG
    Inventor: Robert Cameron
  • Patent number: 6866462
    Abstract: A pedestal for inverting a soft contact lens has been invented. The pedestal of the invention has an inner surface, an outer surface, a dome shape capable of supporting the back surface of the contact lens or the front surface of that contact lens which has been inverted, is made from an elastic material which allows a negative pressure gradient to be generated from the outer surface to the inner surface, and has an elastic top which is capable of collapsing in to invert the contact lens.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: March 15, 2005
    Assignee: Norortis AG
    Inventor: Allen Gilliard
  • Patent number: 6827966
    Abstract: The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: December 7, 2004
    Assignee: Novartis AG
    Inventors: Yongxing Qiu, Fiona Patricia Carney, Nichola Kotov, John Martin Lally, Carol Ann Morris, Lynn Cook Winterton
  • Patent number: 6821108
    Abstract: The invention is concerned with the problem that with known plastic casting moulds, especially those of polypropylene, the lenses produced with these moulds have a slippery surface. The invention solves this problem through the use of polymers which are notable for their very low oxygen permeability.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: November 23, 2004
    Assignee: Novartis AG
    Inventors: Peter Hagmann, Axel Heinrich, Willi Hoerner, Robert Allen Janssen, John Martin Lally, Robert Earl Szokolay, Bernhard Seiferling