Patents Represented by Attorney Jill A. Jacobson

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  • Chemically modified enzymes with multiple charged variants
    Patent number: 7371553
    Abstract: This invention provides modified enzymes comprising one or more amino acid residues replaced by cysteine residues, where the cysteine residues are modified by replacing the thiol hydrogen in the cysteine residues with a substituent group providing a thiol side chain comprising a multiply charged moiety. The enzymes show improved interaction and/or specificity and/or activity with charged substrates.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: May 13, 2008
    Assignees: Genencor International, Inc., The Governing Council of the University of Toronto
    Inventors: Benjamin G. Davis, John Bryan Jones, Richard R. Bott
  • Preparation of a granule containing protein, corn starch and sugar layered on an inert particle
    Patent number: 7300779
    Abstract: Granules that include a protein core are described. The protein core includes a protein matrix which includes a protein mixed together with a starch. The protein matrix can be layered over a seed particle or the protein core can be homogeneous. The protein can be an enzyme or a therapeutic protein.
    Type: Grant
    Filed: September 13, 2004
    Date of Patent: November 27, 2007
    Assignee: Genencor International, Inc.
    Inventors: Nathaniel T. Becker, Thomas S. Green
  • Compositions containing enzymes bound to cationic copolymers
    Patent number: 7297510
    Abstract: Disclosed are a method of adhering active enzymes to an inert support, the product produced thereby, and a method of using the enzyme-coated support in enzyme-catalyzed reactions such as the glucose isomerase-catalyzed conversion of glucose to fructose. The method includes the steps of coating an inert support with a cationic copolymer, preferably a polyamine, and most preferably a di-C1-C6-alkylamino-epichlorohydrin copolymer, and then adhering enzyme to the coated support in the absence of any intervening cross-linking agent.
    Type: Grant
    Filed: April 17, 2002
    Date of Patent: November 20, 2007
    Assignee: Genencor International, Inc.
    Inventor: Norman E. Scheels