Patents Represented by Attorney Jing S. Belfield

Find this attorney in the Justia Lawyer Directory

  • Amide derivatives as inhibitors of matrix metalloproteinases, TNF-&agr;, and aggrecanase
    Patent number: 6376665
    Abstract: The present application describes novel amides and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein these compounds are useful as inhibitors of matrix metalloproteinases, TNF-&agr;, and aggrecanase.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: April 23, 2002
    Inventors: Jingwu Duan, Carl P. Decicco, David J. Nelson, Chu-Biao Xue
  • Integrin receptor antagonists
    Patent number: 6358976
    Abstract: This invention relates to novel fused heterocycles which are useful as antagonists of the &agr;v&bgr;3 and related integrin receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: March 19, 2002
    Inventors: John Wityak, Aleksandra Ewa Tobin
  • Isoxazoline fibrinogen receptor antagonists
    Patent number: 6319937
    Abstract: This invention relates to novel isoxazolines of formula (I): or a pharmaceutically acceptable salt form thereof. This invention also relates to novel isoxazolines of formula (I) which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.
    Type: Grant
    Filed: November 17, 1999
    Date of Patent: November 20, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: John Wityak, Prabhakar K. Jadhav
  • Isoxazoline fibrinogen receptor antagonists
    Patent number: 6303609
    Abstract: This invention relates to novel isoxazolines and isoxazoles of formula (I): or a pharmaceutically acceptable salt or prodrug form thereof. The invention relates to novel isoxazolines which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: October 16, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Joanne M. Smallheer, Shuaige Wang, Prabhakar Kondaji Jadhav