Patents Represented by Attorney Jing S. Belfzeld

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  • Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-? converting enzyme (TACE)
    Patent number: 6890915
    Abstract: The present application describes novel hydantoin derivatives of formula (I): or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R1, R2, R3, R4, R5, R6, R7, R11, and n are defined in the present specification, which are useful as inhibitors of matrix metalloproteinases (MMP), TNF-? converting enzyme (TACE), aggrecanase, or a combination thereof.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: May 10, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: James E. Sheppeck, Jingwu Duan, Chu-Biao Xue, Zelda Wasserman